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COVID-19, Pandemic
mullokintyre
post Posted: Yesterday, 01:33 PM
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Given that the two preferred vaccines for use in the USA (by US pharma companies naturally), and both need to be produced, transported and kept at -70C , the logistics of such a massive vaccination program are starting to be worked out.


According to NEWSMAX
UPS has started the ball rolling.

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Global shipping giant UPS on Tuesday said it would start making dry ice in the United States and also distribute ultra-cold temperature freezers as it prepares to handle the logistics of shipping Covid-19 vaccines.

Facing the world's largest coronavirus outbreak, the US government's Operation Warp Speed plans to distribute 6.4 million doses of the Pfizer-BioNTech vaccine in the first week after it's cleared for emergency use, which could come as soon as December 10.

That vaccine requires ultra-cold long-term storage of -70 degrees Celsius (-94 Fahrenheit), and the company has developed special containers with dry ice to keep it cool for up to 15 days, while other vaccines may also need dry ice in transport.

In a statement, UPS said it had added equipment in its facilities that can produce up to 1,200 pounds of dry ice an hour for the shipping needs of these vaccines, which can be distributed within 24 hours of production to US and Canadian hospitals.

"Healthcare facilities in Louisville, Dallas and Ontario will ensure we have the capability to produce dry ice to sufficiently pack and replenish shipments as needed to keep products viable and effective," Wes Wheeler, president of medical arm UPS Healthcare, said in a statement.

UPS also announced a partnership with freezer manufacturer Stirling Ultracold to distribute freezers capable of reaching temperatures as low as -80 degrees Celsius to doctors' offices, pharmacies and urgent care facilities where the vaccines may be stored for long periods of time.


Given that the frozen CO2 will sublimate back to gaseous form, how will it be counted in US national CO2 emissions??

Mick



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mullokintyre
post Posted: Nov 29 2020, 07:24 PM
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From Science Daily

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Simon Fraser University professors Paul Tupper and Caroline Colijn have found that physical distancing is universally effective at reducing the spread of COVID-19, while social bubbles and masks are more situation-dependent.

The researchers developed a model to test the effectiveness of measures such as physical distancing, masks or social bubbles when used in various settings.

Their paper was published Nov. 19 in the journal Proceedings of the National Academy of Sciences of the United States of America (PNAS).

They introduce the concept of "event R," which is the expected number of people who become infected with COVID-19 from one individual at an event.

Tupper and Colijn look at factors such as transmission intensity, duration of exposure, the proximity of individuals and degree of mixing -- then examine what methods are most effective at preventing transmission in each circumstance.

The researchers incorporated data from reports of outbreaks at a range of events, such as parties, meals, nightclubs, public transit and restaurants. The researchers say that an individual's chances of becoming infected with COVID-19 depend heavily on the transmission rate and the duration -- the amount of time spent in a particular setting.

Events were categorized as saturating (high transmission probability) or linear (low transmission probability). Examples of high transmission settings include bars, nightclubs and overcrowded workplaces while low transmission settings include public transit with masks, distancing in restaurants and outdoor activities.

The model suggests that physical distancing was effective at reducing COVID-19 transmission in all settings but the effectiveness of social bubbles depends on whether chances of transmission are high or low.

In settings where there is mixing and the probability of transmission is high, such as crowded indoor workplaces, bars and nightclubs and high schools, having strict social bubbles can help reduce the spread of COVID-19.

The researchers found that social bubbles are less effective in low transmission settings or activities where there is mixing, such as engaging in outdoor activities, working in spaced offices or travelling on public transportation wearing masks.


The definitive answer!

Mick



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Mags
post Posted: Nov 26 2020, 08:49 PM
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In Reply To: nipper's post @ Nov 26 2020, 06:08 PM

I wont be lining up for no vaccine: I got a bad feeling about how this plays out.

 
nipper
post Posted: Nov 26 2020, 06:08 PM
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In Reply To: mullokintyre's post @ Nov 26 2020, 10:35 AM

QUOTE
Now that we have competing vaccines across the world, it will be interesting to see which ones win the race.
Complementary, I would have thought. It is going to take a while to jab 8 billion ... and some vaccines need double shots.

Cold chain is a real negative, so the Oxford product has distinct advantages. But we do not , as you point out, know the SIDE EFFECTS. And will not until mass immunisation.




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"If I had even the slightest grasp upon my own faculties, I would not make essays, I would make decisions." ― Michel de Montaigne
 
mullokintyre
post Posted: Nov 26 2020, 10:35 AM
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Now that we have competing vaccines across the world, it will be interesting to see which ones win the race.
It would seem that the Oxford Uni/AstraZeneca version hich the OZ govt has put its faith in, does have some advantages.
Firstly, it will remain viable at 4 degrees centigrade or less, whereas the others need to be kept at -70C or less.
its a lot simpler transporting and keeping stuff using a fridge rather than a cryogenic container.
Secondly, there will be different levels of costing. Pharma companies only exist to make a buck, despite their protestations of helping humanity.
Be interesting to see how much each dose costs in various countries.
Thirdly, the important factor of efficacy. Some claim 90% efficacy, others claim 70%. The reality will be somewhat less than the claims whatever they may be.
Fourthly, there is the dreaded side effects of the vaccine.
FromZero Hedge
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European press reports earlier indicated that the EU's pharma regulator is preparing to expedite approval of the AstraZeneca-Oxford vaccine, even as the FDA expands its investigation into the COVID-19 vaccine's Phase 3 trials (after a patient was reportedly seriously sickened in the UK, though AZ insists that illness had nothing to do with the trial).

As the WHO, Bill Gates, Dr. Fauci and the global health-care establishment work with their allies in the press to try and convince as many people as possible to agree to take a COVID-19 vaccine once one is approved, more alarming reports are emerging in the mainstream press about issues with the 'Phase 3' trials.

CNBC reported Thursday morning that several patients involved in trials involving Moderna's vaccine candidate and the Pfizer-BioNTech vaccine candidate have experienced serious side effects, including "shaking so hard he cracked a tooth after taking the second dose."

As bad as they were, the symptoms typically dissipated within a day or two, and four out of the five subjects interviewed by CNBC said they felt the struggle was "worth it" to gain protection from COVID-19. Then again, the symptoms certaintly sound serious.

At least 41 vaccine candidates are in human trials worldwide, but only four US-backed candidates are in Phase 3: Moderna, Pfizer, AstraZeneca and Johnson & Johnson. At least one UK-backed vaccine is also entering Phase 3. While it’s possible some of the symptoms described could have been caused by an unrelated illness, Moderna and Pfizer previously said some participants in their phase one trials experienced mild symptoms. Pfizer emphasized that complications like this were only seen in a small number of cases.

And then theres the problems of patients not returning for the booster dose.

FromZero hedge

QUOTE
Fevers, sweats, migraines and muscle aches that last for days - these are just some of the symptoms reported by various 'Phase 3' trial participants who volunteered for the vaccine trials run by Pfizer, Moderna and others. Though AstraZeneca noted in its preliminary results that its vaccine (which uses the more traditional adenovirus vector) seemed to produce side effects that are less severe than some of its competitors.

As scientists try to ensure the US reaches a 70%+ vaccination rate (the cut-off point at which herd immunity is believed to kick in) a group of doctors just warned that public health officials and drugmakers need to be "transparent" with patients about the potential side effects of vaccination, and ensure precautions are taken to ensure patients don't skip their follow-up visit.

This is a top concern for Dr. Sandra Fryhofer of the American Medical Association, who warned that the side effects might deter many of her patients from receiving the follow-up shot. Dr. Fryhofer expressed her concerns during a virtual meeting on Monday with the CDC and representatives from various vaccine makers

"We really need to make patients aware that this is not going to be a walk in the park," Fryhofer said during a virtual meeting with the Advisory Committee on Immunization Practices, or ACIP, an outside group of medical experts that advise the CDC. She is also a liaison to the committee. "They are going to know they had a vaccine. They are probably not going to feel wonderful. But they've got to come back for that second dose."During the meeting on Monday, Dr. Nancy Messonnier, director of the CDC's National Center for Immunization and Respiratory Diseases who frequently participated in CDC press briefings during the early days of the outbreak, said the agency would work to develop guidance if a health-care worker got a vaccine and then felt unwell the following day, since this could "impact planning on a hospital level in terms of which staff gets vaccinated which day?" she said.

Beyond ensuring hospitals aren't left in the lurch because they decided to vaccinate their entire staff at the same time, the doctors also discussed a novel strategy: using "positive" language to talk about the sideeffects. One example would be referring to side effects as a "response" to the vaccine.

Of course that won't actually do anything to mitigate the side effects.

As one might expect, some patients who participated in the study actually got upset when they didn't experience severe side effects post-vaccination, believing it was a sign they had received the placebo not the actual vaccine.


And finally, how long do the effects of the vaccination last? Is it weeks, months or years? What happens if its only a few months, will people keep going abck for repeat treatments??
All very interesting.
Mick



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Said 'Thanks' for this post: early birds  boylep  
 
early birds
post Posted: Nov 25 2020, 08:03 AM
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https://au.yahoo.com/news/coronavirus-sa-di...-202341916.html

New regulations for hotel staff
Mandatory and regular Covid-19 testing for workers in Adelaide's quarantine hotels has come into force after a dangerous cluster of cases linked to a cleaner who passed the virus onto her family.

The new direction came into force on Wednesday requiring police, SA Health officials, defence force personnel, and all employees and contractors working in the quarantine hotels to be tested weekly.

The rule includes all cleaning and security staff.

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why they didn't have the rule before?? unsure.gif



 


plastic
post Posted: Nov 25 2020, 06:51 AM
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The end is in sight. But still no deal despite this being worth at least $3.2bn if each shot is $20. Probably more.

Who gets the royalties?
And there are going to be a lot of sales reps out of jobs soon.

QUOTE
>EU has deal with Moderna for supply of COVID-19 vaccine candidate- von der Leyen</h1>
BY Reuters— 7:07 AM ET 11/24/2020Nov 24 (Reuters) - The European Union has reached a deal with U.S. biotech firm Moderna ( MRNA) for the supply of up to 160 million doses of its COVID-19 vaccine candidate, the president of the European Commission said on Tuesday.



The deal will be formally approved by the EU executive on Wednesday, Ursula von der Leyen said. (Reporting by Francesco Guarascio @fraguarascio; Editing by Jon Boyle)




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What did Uncle Mel do to us?
 
Mork
post Posted: Nov 24 2020, 09:05 AM
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Portuguese Court Rules PCR Tests "Unreliable" & Quarantines "Unlawful"Via Off-Guardian.org,
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An appeals court in Portugal has ruled that the PCR process is not a reliable test for Sars-Cov-2, and therefore any enforced quarantine based on those test results is unlawful.

Further, the ruling suggested that any forced quarantine applied to healthy people could be a violation of their fundamental right to liberty.

Most importantly, the judges ruled that a single positive PCR test cannot be used as an effective diagnosis of infection.

The specifics of the case concern four tourists entering the country from Germany – all of whom are anonymous in the transcript of the case – who were quarantined by the regional health authority. Of the four, only one had tested positive for the virus, whilst the other three were deemed simply of “high infection risk” based on proximity to the positive individual. All four had, in the previous 72 hours, tested negative for the virus before departing from Germany.

In their ruling, judges Margarida Ramos de Almeida and Ana Paramés referred to several scientific studies.

Most notably this study by Jaafar et al., which found that – when running PCR tests with 35 cycles or more – the accuracy dropped to 3%, meaning up to 97% of positive results could be false positives.

The ruling goes on to conclude that, based on the science they read, any PCR test using over 25 cycles is totally unreliable.

Governments and private labs have been very tight-lipped about the exact number of cycles they run when PCR testing, but it is known to sometimes be as high as 45. Even fearmonger-in-chief Anthony Fauci has publicly stated anything over 35 is totally unusable.

You can read the complete ruling in the original Portuguese here, and translated into English here. There’s also a good write up on it on Great Game India, plus a Portuguese professor sent a long email about the case to Lockdown Sceptics.

* * *

The media reaction to this case has been entirely predictable – they have not mentioned it. At all. Anywhere. Ever.

The ruling was published on November 11th, and has been referenced by many alt-news sites since…but the mainstream outlets are maintaining a complete blackout on it.

The reddit Covid19 board actually removed the post, because it was “not a reliable source”, despite relying on the official court documents:

https://www.zerohedge.com/political/portugu...ntines-unlawful




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plastic
post Posted: Nov 23 2020, 09:16 AM
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Who's gonna get the royalties if there are any. I have never read the vaccine is proprietary to Pfizer.

QUOTE
A panel of outside experts that advises the FDA is expected to meet on December 10 to discuss Pfizer's application for an emergency use authorization.

Slaoui, a former executive at GlaxoSmithKline and Moderna board member, said also Sunday that the Pfizer vaccine could be distributed to some people in the US as early as December 11 if it received an authorization on the same day the panel convenes to discuss it.




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What did Uncle Mel do to us?
 
early birds
post Posted: Nov 19 2020, 03:44 PM
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https://www.cnbc.com/2020/11/19/wuxi-biolog...treatment-.html

Chris Chen, chief executive officer at China’s WuXi Biologics, expects approval for a Covid-19 antibody treatment either “late this year or early next year, ” he told CNBC.

WuXi Biologics, which sells outsourced laboratory and manufacturing services to biotech companies, has signed several deals with clients to research antibodies for delivering coronavirus treatments.

“We are working on 10 neutralizing antibodies and also on one Covid-19 vaccine. Some major progress is going on with these treatments,” he told Emily Tan, speaking to CNBC as part of the annual East Tech West conference.

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if they can show it's safe and effective -------then it'll be the game change, because people not gonna fear to caught the virus anymore [ will be treated and won't die from it]. just like that swine flu treatment few years ago. fingers crossed!!



 
 


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