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juxtaposer
Posted on: Yesterday, 09:07 AM


Group: Member
Posts: 153

I and it seems an increasing number of people believe LevelHeaded2000 no longer has any credibility. The overnight personality change from well informed enthusiast to manic depressive doomsdayer following the achievement of FDA approval seems so extraordinary that I can come to no other conclusion that he is a paid troll working for shorter or takeover merchants.

Time to invent a new name LevelHeaded2000, perhaps you could try Ignoramus that hasn't been used for a while.
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juxtaposer
Posted on: Dec 3 2019, 01:53 PM


Group: Member
Posts: 153

Good questions.
Maybe it's time for you sit down and tell us a bit about yourself Levelhead and just why we should,
after this change in behaviour and "special" post FDA discovery, take you and what you say seriously.
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juxtaposer
Posted on: Dec 3 2019, 01:13 PM


Group: Member
Posts: 153

"Shouldn’t you be way more worried about the long term member that overnight and at a critical time flips their bullish outlook on Clinuvel and instantly cheerleads for a phase2 unproven (non peptide) drug under the guise that they are just presenting a counter argument?"

Yep it's an extraordinary bit of timing REALLY DOES BEG A QUESTION OR TWO regarding Levelhead.

Complete personality change with no explanation of the timing of his DISCOVERY of this previously unknown research.

You could've been excused for thinking prior to the FDA decision that it might be PW in disguise and now that he is a soldier troll for a takeover merchant.

Fascinating stuff that we will never learn the truth of.

As the great journalist Paul Lyneham said to me once....

"ME, cynical?
I'll tell you how cynical I am,
I'm so cynical I'd believe anything".

Then he'd set about finding the truth.

It will out in the end.
(to paraphrase)
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juxtaposer
Posted on: Nov 29 2019, 03:46 PM


Group: Member
Posts: 153

The Shakedowncafe has been very successful this week -
got the Nervous Nellie’s well and truely worked up.

Shorters Paradise where the weather changes in an instant.
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juxtaposer
Posted on: Nov 27 2019, 07:22 PM


Group: Member
Posts: 153

Vitiligo Dolls
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juxtaposer
Posted on: Nov 20 2019, 02:19 PM


Group: Member
Posts: 153

Not to me
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juxtaposer
Posted on: Nov 20 2019, 12:36 PM


Group: Member
Posts: 153

In a conversation after PW said it would be P2 trial.
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juxtaposer
Posted on: Nov 10 2019, 07:44 AM


Group: Member
Posts: 153

I’ll be there to congratulate the team once again (was there in 2014 post EMA) and especially PW. He has made my recent retirement VERY comfortable.
I have been known to enjoy the occasional drink.
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juxtaposer
Posted on: Nov 10 2019, 06:31 AM


Group: Member
Posts: 153

It really is hard to tell with some of these posts as to whether some people here are half glass empty, downrampers or just ego driven grandstanders.

This CEO dragged CUV through shark infested waters on a ridiculously long and perilous journey to an ideal FDA approval from which we will ALL benefit, some massively.
He could’ve left at anytime but stayed on, galvanized loyalty in his staff and here we are.

It may amuse some to trawl through every reef and storm in the journey but personally I am eternally grateful we had a skipper and crew with the Skill, stamina and resilience to get her home.
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juxtaposer
Posted on: Oct 23 2019, 03:46 PM


Group: Member
Posts: 153

None framed but have a few.
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juxtaposer
Posted on: Oct 11 2019, 09:03 AM


Group: Member
Posts: 153

Yeah we might be getting older but I heard about this fabulous new drug they reckon is the fountain of youth that just got passed by the FDA!
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juxtaposer
Posted on: Oct 10 2019, 06:33 AM


Group: Member
Posts: 153

Link to recording of yesterday's phone conference
Clinuvel Phone Conference
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juxtaposer
Posted on: Oct 10 2019, 05:50 AM


Group: Member
Posts: 153

AFR

Australian Financial Review
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juxtaposer
Posted on: Oct 9 2019, 05:41 PM


Group: Member
Posts: 153

Far from it.
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juxtaposer
Posted on: Oct 9 2019, 05:08 AM


Group: Member
Posts: 153

Back in the late 1990s my son was sitting in a Medical Science lecture on melanin. He turned to his friend and said “ imagine if you could artificially stimulate production of that? We should get into that”. His friend replied “Too late there’s a company in Melbourne already doing it”. And so it began. We were scraping by putting 2 kids through uni and had little money to invest.

Then Epitan fell over and it all seemed to go down the drain. The remnants of the company hired Phillipe Wolgan so my son sent him a letter with a few ideas on what he thought they might do. At this time my son was doing his honours year locked up in the animal house putting sun screen on naked mice. PW replied and flew him down to Melbourne and offered him a job. For various reasons he didn’t take it up but he came away very impressed with the new team leader.

This board and my son’s belief in the science has fed the stamina necessary during the desperate days over the years.

The real winners here are the EPP sufferers and PW and Deseree Lyon (?) who have kept this ship on course through the appalling storms along the way.

Everyone can enjoy the sunshine that has finally broken out on this extraordinary drug.

Congratulations!!!
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juxtaposer
Posted on: Oct 7 2019, 07:59 AM


Group: Member
Posts: 153

Having just watched the NRL grand final and seeing once again how the referee can throw the game it starts to eat away at my optimism (since 2003) ....... a bit.
As Leonard Cohen said “ Everybody Knows”.

Everybody Knows



Naaaaa it’s a shoe in.

Bring on Wednesday!
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juxtaposer
Posted on: Aug 6 2019, 11:19 PM


Group: Member
Posts: 153

The ABC the AFL and the “Barby” drug.

https://mobile.abc.net.au/news/2019-08-06/p...062?pfmredir=sm
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juxtaposer
Posted on: Aug 5 2019, 09:21 AM


Group: Member
Posts: 153

This fits with what a physician told me once. In plain words - Have heart attack get Scennese within 20 - 30 minutes and it will save you from damage.
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juxtaposer
Posted on: Jun 23 2019, 05:22 AM


Group: Member
Posts: 153

He’s there in your thanks. Wonder if he still holds 1 million?
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juxtaposer
Posted on: Jun 22 2019, 09:59 PM


Group: Member
Posts: 153

Hey welcome back Madman !
Just had a look it’s been 3 years it seems.
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juxtaposer
Posted on: Jun 22 2019, 10:23 AM


Group: Member
Posts: 153

Adverse effects described in the medical literature as of 2017 included nausea, flushing, headache, injection-site pain and itchiness, and upper respiratory tract infections.
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juxtaposer
Posted on: Jun 21 2019, 10:17 AM


Group: Member
Posts: 153

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juxtaposer
Posted on: Jun 17 2019, 09:55 AM


Group: Member
Posts: 153

Avita would be a good fit.
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juxtaposer
Posted on: Jun 14 2019, 12:44 PM


Group: Member
Posts: 153

I use Commsec. I had a brief experience of the appalling Brightday now Yellow Brick Road recommended by Eureka Report's Alan Kohler. A disater of hidden fees and frequent delayed totally screwed up transactions. Don't go there!

Apart from Commsec being owned by the evil CBA I'm quite happy. The web interface can be a little convoluted and less than intuitive but it works for me.
I love it when it warns me of the dangers that over 85% of my portfolio is CUV.
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juxtaposer
Posted on: Jun 3 2019, 09:25 PM


Group: Member
Posts: 153

"The FDA is a cruel and shallow money trench, a long plastic hallway where thieves and pimps run free, and good men die like dogs.”
(After Hunter S. Thompson)
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juxtaposer
Posted on: May 27 2019, 08:43 AM


Group: Member
Posts: 153

From Medscape. "All four chemicals achieved blood levels higher than that 0.5 ng/mL threshold. In fact, with the exception of ecamsule, they blew right through it. The average peak oxybenzone level was around 200 ng/mL�"that's 400 times higher than the level to trigger a formal toxicology review."
Is the Sunscreen Scare Legitimate?
How Does It Compare With Caffeine From Coffee, or Nicotine From Cigarettes? F. Perry Wilson, MD, MSCE

May 21, 2019

"Be nice. Wear your sunscreen. I love you."

I uttered this mantra every day as my kids were whisked off to day camp last summer, cognizant of the burns I suffered as a free-wheeling and UV-exposed youth. I knew there was ample biological evidence that sunscreen, by preventing severe burns, would reduce their risk for skin cancer in the future. This is #GoodParenting.

And then I came across a recent article in JAMA[1] that kicked the parental guilt into high gear. The study showed that the active ingredients in many chemical sunscreens had significant systemic absorption. And the truth is, we have no idea if that matters.

Why was this study done now?

Sunscreens are treated as over-the-counter medicines in the United States, but they were put on the market before the modern era of oversight by the US Food and Drug Administration (FDA), meaning the FDA had not (yet) evaluated their potential toxicity. Then last year, the FDA created a guidance document with a specific suggestion: If any of the active ingredients in sunscreen achieve a steady-state blood level of greater than 0.5 ng/mL, formal toxicology studies should be performed.

That 0.5 ng/mL level is not arbitrary. It's the same level that the FDA uses to determine whether impurities introduced in drug manufacturing need to be evaluated for toxicity. It's the "OK, do we need to worry about this?" level.

The FDA researchers conducted a formal pharmacokinetic study with 24 healthy volunteers who were cooped up (indoors, without sunlight) for a week. According to manufacturer instructions, sunscreen was applied four times a day for the first 4 days, mimicking what you might do on a typical vacation somewhere sunny. Throughout their stay, their blood was tested for levels of avobenzone, oxybenzone, octocrylene, and ecamsule (the most common active ingredients).

All four chemicals achieved blood levels higher than that 0.5 ng/mL threshold. In fact, with the exception of ecamsule, they blew right through it. The average peak oxybenzone level was around 200 ng/mL�"that's 400 times higher than the level to trigger a formal toxicology review.

This study was preliminary, but if you look at the drug concentration curves, you can make a couple of inferences. First, the average drug level increased each day during the 4 days that sunscreen was applied. This means that there is drug accumulation (at least when you are applying it four times a day).

You can also see that drug washout was rather slow. Although the authors don't provide the specific numbers, the half-life of the drug appears to be on the order of a few days�"meaning that over a summer of use, this could really add up.

More formal, longer-term studies are needed, and the FDA has stated that it has asked industry and "other interested parties" to conduct them. Sunscreens will stay on the market for now.

And that's fine. Thinking about it, is it any surprise that these chemicals are absorbed? A quick glance at their chemical structures show interconnected benzene rings that just scream "fat-soluble."

But just because something gets into your body doesn't mean it's bad for you. I know these compounds have chemical names, but the assumption that artificial compounds are worse for you than all of the other stuff we put in our bodies is known as the "naturalistic fallacy." By way of comparison, the average blood level of caffeine after a cup of coffee is 50 times higher than the peak concentration of oxybenzone seen in this study. But that oxybenzone level is about seven times higher than the blood nicotine level seen after smoking a cigarette.

In other words, the fact that you can measure something in the blood doesn't tell you anything about whether it is bad for you. We simply don't know what the risk is. And we need to find out.

Personally, I wouldn't call for a freeze on chemical sunscreens. These drugs have been used for decades and there have been no strong epidemiologic signals of harm. Quite the opposite, they have probably prevented uncounted cases of skin cancer.

The problem with studies like these is that the fear they engender may do more harm than the good science that results from them. Nothing has changed about the harm of UV rays since the publication of this study in JAMA; you still don't want your skin exposed to them.

But it may be worth remembering that chemical sunscreens are not the only option. Clothing and hats provide excellent sun protection, and the systemic absorption of a sombrero is pretty low. And, of course, there are barrier sunscreens (formulated with zinc and titanium dioxide) which, yes, leave you looking like an 18th century consumptive, but which are generally regarded as safe.

This summer, my mantra may change a bit: "Be nice. Wear your embarrassingly white sunscreen. I love you."

References
  1. Matta MK, Zusterzeel R, Pilli NR, et al. Effect of sunscreen application under maximal use conditions on plasma concentration of sunscreen active ingredients. A randomized clinical trial. JAMA. 2019 May 6. Source
Medscape Internal Medicine © 2019 WebMD, LLC

Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.
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juxtaposer
Posted on: May 24 2019, 06:15 AM


Group: Member
Posts: 153

All of the above. Yes it isn’t a competition so I’ll add, sadly for just a brief appearance, Duane Allman.





“You’re my Blue Sky” CUV and I hope the FDA doesn’t treat you like they are SPL in this age of nationalistic trade wars.
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juxtaposer
Posted on: May 17 2019, 10:27 PM


Group: Member
Posts: 153

AMT Allegra Orthopaedic 3D printed bone repair.
DYOR which I’m sure you will.
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juxtaposer
Posted on: May 8 2019, 07:10 AM


Group: Member
Posts: 153

Topical rather than systematic implant.
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juxtaposer
Posted on: May 2 2019, 04:12 PM


Group: Member
Posts: 153

Could be a great motivator for the long suffering patients to get up and bring on last minute pressure.
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juxtaposer
Posted on: Apr 30 2019, 07:13 PM


Group: Member
Posts: 153

Ha!
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juxtaposer
Posted on: Apr 28 2019, 01:57 PM


Group: Member
Posts: 153

"What’s stopping you?"
Availability.
I'm not prepared to go down the online knockoff line.Besides that Clinuvel picture on Twitter recently of a purple/blue/grey lotion
from their Singapore office during #PorphyriaAwarenessWeek sure looks interesting.
Porphyria Awareness Week
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juxtaposer
Posted on: Apr 26 2019, 11:26 PM


Group: Member
Posts: 153

I’m heading off soon to sail around the islands of New Caledonia and Points north and with three chunks having been cut from my face already and more sure to come I’d be getting my hands on this quick as a flash if I only could. Nothing too cosmetic about that and what I pick up in side effects like DNA repair and an anti inflammatory grease and oil change well that’s just fine by me as well. Three cheers for PW for ignoring these “expert” screen jockeys there’s more important things to do.

It will pay off in the end.
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juxtaposer
Posted on: Apr 26 2019, 11:11 PM


Group: Member
Posts: 153

Taleb (of Black Swan) is right nobody knows anything especially when it comes to these “experts”.
Those of us who have been around for such a looong time (av buy in $3.10) and been privy to all the scientific research (solid facts) and have learned over time to read PW’s minuscule tidbits of where we are going know that these expert “analysts” know very little other than promising looking dirt that just maybe might get them that Point Piper mansion. Biotech is just too hard for these guys and requires a stamina that they just don’t have. Here it is staring them in the face and they haven’t got a clue of what they are looking at. A motley bunch of fools who just won’t be coming to the party.
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juxtaposer
Posted on: Apr 25 2019, 10:10 PM


Group: Member
Posts: 153

If it’s the same review of dendrimers I read my take away was a possible CUV/SPL collaboration to be had in transdermal usage.
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juxtaposer
Posted on: Apr 4 2019, 12:35 PM


Group: Member
Posts: 153

Yes Avita has been an exciting ride! Not sure you can compare with CUV though.
A brilliant product but with 1.8billion shares out there and a feeling that management is
a bit more science than international management.
However it’s all coming together now and glad I picked up the tip here and acted on it.

All this is in my mind a stark contrast to our PW’s way of operating.
As someone said to me recently Everything PW does is strategic.
So far (and it’s been a hell of a long road) it looks to me that PW has been sure footed the whole way.
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juxtaposer
Posted on: Mar 22 2019, 12:13 PM


Group: Member
Posts: 153

IntiRaymi
You didn't do Medical Science at Usyd did you?If you did then you are responsible for my original purchase of CUV way back then via my son Paul.
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juxtaposer
Posted on: Mar 22 2019, 12:09 PM


Group: Member
Posts: 153

Avita Medical

AVMXY:US closed at 3.55 up 23% on the day.
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juxtaposer
Posted on: Mar 22 2019, 05:21 AM


Group: Member
Posts: 153

Yes thank you IntiRaymi I bought on that recommendation and have now more than doubled my money.
A very exciting little company with an amazing technology, spray on skin.
Invented by Australian of the year Fiona Wood.

Has already dramatically changed the lives of so many burns victims especially children in West Aust.
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juxtaposer
Posted on: Mar 14 2019, 07:01 AM


Group: Member
Posts: 153

It seems the biggest purchaser of shares recently has been Clinuvel adding almost a million to it’s total
Giving it voting rights of 9.24%. (PW now has 6.73%)

Wonder what the plan is?
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juxtaposer
Posted on: Mar 7 2019, 05:55 AM


Group: Member
Posts: 153

CUVs Twitter feed has announced....

We are experts in optical physics and aspire to create an ideal #environment for future generations.
Therefore, over the next five Wednesdays, we are delving into renewable energy powered by sunlight.

Stay tuned to learn how #SolarPanels work!

#CLINUVEL #EcoWednesday”
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juxtaposer
Posted on: Mar 4 2019, 10:39 PM


Group: Member
Posts: 153

Im only just starting to “get it “ having waited since 2003. PPP
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juxtaposer
Posted on: Feb 22 2019, 12:15 PM


Group: Member
Posts: 153

FDA proposes new regulations for over-the-counter sunscreens
https://www.reuters.com/article/us-fda-suns..._source=twitter
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juxtaposer
Posted on: Feb 20 2019, 01:18 PM


Group: Member
Posts: 153

Who, when, what multiple do reckon X-Ray?
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juxtaposer
Posted on: Oct 4 2018, 09:24 AM


Group: Member
Posts: 153

Won’t the implants make both the light AND the dark areas darken at the same ratio?
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juxtaposer
Posted on: Sep 27 2018, 08:31 PM


Group: Member
Posts: 153

$70 I’ll sell half and keep half.
But hang on, a week or so ago I thought I’d sell half at $25.
Right now there is no way I’d sell half at $25 even after 15 years.
Gonna ride this to $70 now, all of a sudden I feel younger than I am.
Looking forward to the AGM.
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juxtaposer
Posted on: Sep 24 2018, 11:33 AM


Group: Member
Posts: 153

Remember all those years ago when Phillippe said "it will pay off in the end"?
Well it isn't the end.......
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juxtaposer
Posted on: Sep 19 2018, 06:46 AM


Group: Member
Posts: 153

“here are the closing prices for the last 5 trading days: $17.80 > $18.05 > $18.13 > $18.26 > $18.49 ”

and Germany currently A$18.70
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juxtaposer
Posted on: Sep 14 2018, 06:05 PM


Group: Member
Posts: 153

Here's a couple of Fidelity experts talking about luke warm health stocks. One size fits all? (July 2018)

Fidelity
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juxtaposer
Posted on: Sep 14 2018, 09:28 AM


Group: Member
Posts: 153

FIL just reduced holding in SPL. strange given that both are waiting on FDA approval with EMA already in the bag. I
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juxtaposer
Posted on: Aug 8 2018, 07:43 AM


Group: Member
Posts: 153

Nassim Nicholas Taleb (Wall St Quant, hedge fund operator, GFC seer and wrote Black Swan) quotes the great Hollywood screen writer William Goldman whose observation about those who ran things in Hollywood "Nobody knows anything" hence they make 10 films in the hope two will go gang busters.
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juxtaposer
Posted on: Jul 12 2018, 04:12 PM


Group: Member
Posts: 153

The NDA for SPL is just the entree. The main course is an endless list of re-invented re-patented oncology (and other) drugs coming down the track. Minuscule amounts of existing drugs being delivered on the SPL dendrimers. Read the research on that. The forum for SPL is on Hotcopper. https://hotcopper.com.au/asx/spl/
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juxtaposer
Posted on: Jun 24 2018, 09:36 AM


Group: Member
Posts: 153

16. PW reinvests his massive profits in trying to find a cure for "Footballer falling down and crying" disease. Finally dies years later a homeless sad depressed failure as no cure was found.
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juxtaposer
Posted on: May 13 2018, 07:31 AM


Group: Member
Posts: 153

73,600
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juxtaposer
Posted on: May 12 2018, 06:10 AM


Group: Member
Posts: 153

“On Friday afternoon, President Donald Trump is expected to lay out his ideas for lowering drug prices”

https://www.bloombergquint.com/onweb/2018/0...rics#gs.UuTIclU
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juxtaposer
Posted on: Apr 28 2018, 06:11 AM


Group: Member
Posts: 153

Yes I’ve been with Starpharma (SPL) as well for a long time and agree it is sitting at a very interesting place right now.
I also have had Allegra Orthopaedics (AMT) for some time. They have a 3D printed bone replacement that is well down the track towards release.
I am very happy to be in both but dyor of course.
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juxtaposer
Posted on: Feb 21 2018, 09:54 PM


Group: Member
Posts: 153

Looks like I may have stumbled on an earlier draft of the logo with a deer instead of the frill neck lizard.

Try this 404 error page

http://clinuvel.com/products-pipeline/pipeline

Clinuvel 404
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juxtaposer
Posted on: Jan 31 2018, 09:32 PM


Group: Member
Posts: 153

SPL

And I’ve been in CUV since 2003.
2018 looking good for both.
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juxtaposer
Posted on: Nov 29 2017, 11:14 AM


Group: Member
Posts: 153

Did all those sunscreen lotions with nanoparticles that we buy to save our skins go through Ph1,2,3 trials or did they just go on the market?
Did Horny Goat Weed Libido Enhancer for Men and Women get approval after Ph1,2,3 trials? You can buy it now online from Melbourne.
LINK
And what about the claims of all those Swisse products flogged on TV and regularly exposed as nonsense by the Chaser guys on The Checkout - ALL approved?
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juxtaposer
Posted on: Nov 29 2017, 07:37 AM


Group: Member
Posts: 153

Q3/4 2018 Launch Clinuvel Skin Care solutions 2 distribution channels in Asia?

Hmm wonder what that could be?
Trying to guess here.
From what I understand (correct me if wrong) if you make no outrageous claims as to the outcomes of your product it is possible to do OTC.
OTC skin care products that may not just darken your skin but also repair damage would quickly begin to sell themselves. May even be useful for combined UV vitiligo treatment.

Maybe this is all too fanciful.
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juxtaposer
Posted on: Nov 22 2017, 08:43 AM


Group: Member
Posts: 153

So have I. 2003/5 and both approaching the launch pad at the same time. Very exciting times indeed after many years of waiting. SPL is just as exciting as CUV. DYOR.
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juxtaposer
Posted on: Oct 18 2017, 01:36 PM


Group: Member
Posts: 153

For the record I did not intend to say thanks to ignoramous it was a slip of the finger on the iPhone.
Can’t remember a single post of ign that I would say thanks to.

PW has my full support even after 14 years. Astounding that he has remained so committed through the extraordinary struggle to get this approved.
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juxtaposer
Posted on: Oct 11 2017, 06:59 AM


Group: Member
Posts: 153

I've been in since 2003 and agree wholeheartedly Royco.
I'm in (and have been) for the long run though it is looking increasingly like my grandchildren will be the beneficiaries.
I will NOT be selling!

"Can anyone find a better investment opportunity?"

Well I know one that is equally good that I've been in just as long - Starpharma (SPL) and it is just entering countdown to take off.
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juxtaposer
Posted on: Oct 11 2017, 06:56 AM


Group: Member
Posts: 153

.
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juxtaposer
Posted on: Sep 8 2017, 09:37 AM


Group: Member
Posts: 153

I'm betting on Chivere it can be selectively applied. Systemic makes everything darker as I understand it.
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juxtaposer
Posted on: Aug 26 2017, 07:11 AM


Group: Member
Posts: 153

Is Your Sunscreen Poisoning the Ocean?

https://mobile.nytimes.com/2017/08/19/opini.../m.facebook.com
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juxtaposer
Posted on: Aug 1 2017, 08:38 AM


Group: Member
Posts: 153

I usually find Royco's posts to be among the most useful here however every now and then he he sticks the knife into PW and writes a post like this.
Can only put it down to a bad day/night.
I agree whole heartedly with NewToCli's comments.

I'm wondering if once we have FDA approval whether Vitiligo will be serviced by Vallaurix with OTC topical.
Oh and then there are all the other reasons to be excited about a topical.
That would give things a bit of a kick especially with Singapore-Asia and a much bigger US presence.
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juxtaposer
Posted on: Jun 30 2017, 06:37 PM


Group: Member
Posts: 153

Phew!
That's great, no announcement today - much better for my superannuation.
If it had blown out this month I would have been juggling super accounts.
My other iron in the fire that was also expecting news, SPL, also rode past an expected June 30 announcement deadline. Phew#2.

When you're in for the long run a few days can sometimes be significantly significant.

-----------
My bios
SPL CUV AMT CSL
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juxtaposer
Posted on: Jun 27 2017, 07:49 AM


Group: Member
Posts: 153

Martin Shkreli appeared in a New York federal court Monday for the start of his securities fraud trial—and was quickly declared guilty of price gouging by potential jurors.

https://arstechnica.com/science/2017/06/pot...r-epipen-price/
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juxtaposer
Posted on: May 23 2017, 09:28 AM


Group: Member
Posts: 153

But will the topical have a role in vitiligo?
My understanding is that it will.
What is the OTC preparation hinted at during the AGM?
Where does Singapore fit into all of this?
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juxtaposer
Posted on: Feb 19 2017, 12:56 PM


Group: Member
Posts: 153

QUOTE
D Lyons could think about sending an APF delegation straight to the president of the USA and explain him where things go wrong with this agency.


Not a bad idea Royco but there may be another door to Trump's ear.

D Lyons husband Dr Richard J Howe is an ex Exxon exec (!) and Trump has appointed Exxon CEO Rex Tillerson as Secretary of State.
It's well known that Trump has an interest in tanning and has expressed concern at the way delays in FDA approval add to the cost of drugs.

Could be some synergies there somewhere.

Dr Richard J Howe
http://www.houstonamericanenergy.com/prview.html?id=259

Desiree Lyon
http://www.porphyriafoundation.com/about-t...es/desiree-lyon
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juxtaposer
Posted on: Nov 8 2016, 08:37 PM


Group: Member
Posts: 153

I too have a problem with these shares.

I've lost count how many times over the last 12 years I've said "that's it, no more, I've got enough".
My relapse has been particularly chronic in the last week or so with 4 more episodes as the price has been dropping.
I'm currently looking at a 171% return on my overall investment and every new visit to the broker erodes that % further ..... for the moment.

It's "only just begun".

It WILL pay off in the end.
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juxtaposer
Posted on: Nov 8 2016, 07:06 AM


Group: Member
Posts: 153

Been buying over the last 5 days.
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juxtaposer
Posted on: Oct 24 2016, 10:57 AM


Group: Member
Posts: 153

Unfortunately my purchase this morning dropped the price a tad. wacko.gif


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juxtaposer
Posted on: Sep 19 2016, 12:39 PM


Group: Member
Posts: 153

Yes I remember that chat. I suggest Lord Howe Island a perfectly wonderful place and relatively shyster free. No bots allowed. Will raise a toast to PW for hanging in there and never giving up.
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juxtaposer
Posted on: Sep 2 2016, 07:53 AM


Group: Member
Posts: 153

A number of years ago Clinuvel posted photos of a girl in a bikini with distinct tan lines. It was clear that the tan stopped where she had been wearing bicycle shorts and sox. This was a demonstration of the topical as I remember.
I believe they are no longer available on the website. Perhaps someone has a copy?
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juxtaposer
Posted on: Jul 14 2016, 04:26 PM


Group: Member
Posts: 153

"Do we know whether CUV9900 gives a localised or systemic tan?"

Those who have been in this for the very LONG run may remember the Clinuvel posting (way back) of photos of the girl in the bikini with tan lines where she had clearly been wearing bike shorts and socks. CUV 9900. It is localised which I understand is handy for vitiligo.

I have an Immunologist/rheumatologist in my family who is very keen to get his hands on a safe alternative to prednisone. He is convinced through studies done so far and because of its safety profile that this is an extraordinary anti inflammatory and should be available.
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juxtaposer
Posted on: May 29 2016, 10:35 AM


Group: Member
Posts: 153

Good luck with the hypertension.
Have they got the funds for this?
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juxtaposer
Posted on: May 28 2016, 09:17 AM


Group: Member
Posts: 153

My understanding is that Palatin is based on Melanotan2 and Scenesse is Melanotan1.
Melanotan 2 causes hypertension and the FDA cancelled a Palatin clinical trial some years ago because of this.

Stan McLiesh is right Scenesse's safety is it's greatest asset.
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juxtaposer
Posted on: May 20 2016, 11:55 AM


Group: Member
Posts: 153

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juxtaposer
Posted on: May 19 2016, 10:08 AM


Group: Member
Posts: 153

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juxtaposer
Posted on: May 19 2016, 10:03 AM


Group: Member
Posts: 153

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juxtaposer
Posted on: May 18 2016, 10:42 PM


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Posts: 153

The implant is systemic - in lay terms goes internally through the whole body system.
The cream is topical - applied directly to the skin. Have you ever used a cream that is labeled " not for internal use"?
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juxtaposer
Posted on: Mar 15 2016, 09:43 AM


Group: Member
Posts: 153

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juxtaposer
Posted on: Mar 15 2016, 09:36 AM


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In addition to sitting cash comfortable feeding the the Yanky sharks a few tasty morsels may go some way further towards keeping the FDA on side. The extreme prejudiced in the past towards foreign applicants is worth considering.
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juxtaposer
Posted on: Nov 17 2015, 08:33 AM


Group: Member
Posts: 153

And this is a platform with multiple possibilities.
So many drugs can be attached and targeted. All the off patents and perhaps even some that failed to be passed but when delivered by dendrimer are now feasible.
Not to forget veterinary and agro-chemical applications.
Dow when they owned it had plans for lubricants and adheasives! Goodness knows why they let it go.
The potential seems extraordinary.
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juxtaposer
Posted on: Nov 16 2015, 11:41 AM


Group: Member
Posts: 153

Melbourne, Australia; 16 November 2015:

Starpharma (ASX: SPL, OTCQX: SPHRY)
today announced that treatment with its novel antibody-targeted DEP
conjugate resulted in complete tumour regression and 100% survival in an ovarian cancer model.

http://www.starpharma.com/assets/asxannoun...utperforms_.pdf
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juxtaposer
Posted on: Sep 7 2015, 12:25 PM


Group: Member
Posts: 153

Small Melbourne biotech signs licensing agreement with AstraZeneca

http://www.starpharma.com/assets/asxannoun...announcemen.pdf
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juxtaposer
Posted on: Sep 7 2015, 12:18 PM


Group: Member
Posts: 153

Just the start of something big.
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juxtaposer
Posted on: Aug 18 2015, 06:29 PM


Group: Member
Posts: 153

I first jumped on board in 2003, been steadily accumulating ever since. Frustrated yes but still hanging in.
All the nervous nellies are just wasting their breath with their impatience. PR at the moment is trader stupidity.

Steady as she goes Mr. W. I'm still with you. This little black swan is going to get there, eventually.

I can wait, just as I am also doing with similarly small fish AMT and SPL.

"Ever done the opposite of what the experts say?"
Bob Dylan
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juxtaposer
Posted on: Mar 16 2015, 03:01 PM


Group: Member
Posts: 153

I asked him directly about that (inflammation) and he was very dismissive. I was quite surprised.
It may well have been the poker player at work and also being mindful of one step at a time - marketing in Eu and Vitiligo.
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juxtaposer
Posted on: Jan 6 2015, 08:02 AM


Group: Member
Posts: 153

Scenesse still under the radar -

http://www.abc.net.au/health/talkinghealth.../05/4142894.htm
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juxtaposer
Posted on: Dec 23 2014, 10:52 AM


Group: Member
Posts: 153

Ec approves Senesse.
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juxtaposer
Posted on: Dec 22 2014, 05:48 AM


Group: Member
Posts: 153

Inflammation, the immune system and Alzheimer's


http://www.theguardian.com/science/2014/de...mmune-disorders
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juxtaposer
Posted on: Dec 1 2014, 05:48 PM


Group: Member
Posts: 153

Keep your eye on CUV9900.
Internet forums are worth every cent you pay for them.
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juxtaposer
Posted on: Dec 1 2014, 07:20 AM


Group: Member
Posts: 153

Thanks for the clarification.
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juxtaposer
Posted on: Nov 30 2014, 08:05 PM


Group: Member
Posts: 153

Absolutely, a takeover is a rediculous waste, probably good for the Johnny Come Latelies but this little puppy has years of life ahead of it under the current leadership.
It's interesting to read the spin coming from the JCL's, as has been noted before.
I wonder if they are related to the bots out there driving the price down?

Big Pharma want this, the battle is only warming up.

Hold
Accumulate
Hold

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juxtaposer
Posted on: Nov 30 2014, 02:42 PM


Group: Member
Posts: 153

What were those photos of a few years back of the girl in the bikini showing bicycle short and sox tan lines?
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juxtaposer
Posted on: Nov 30 2014, 12:10 PM


Group: Member
Posts: 153

While speaking to me before the meeting Lachlan said the implant changes both dark and light areas and therefore application of CUV 9900 directly onto the light area is a much better way.
Here comes CUV 9900!
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juxtaposer
Posted on: Nov 30 2014, 09:23 AM


Group: Member
Posts: 153

I'm not sure if you attended the meeting Snaf but if you did you would have understood just what an extraordinary effort it was to bring this company back from the smelly grave it was buried in. 900 odd days in the approval process was clearly not the preferred path of the management. The strategy they employed from the beginning was first class, the hoops and fire pits thrown in their way were skillfully negotiated. It is imperative that this team with the proven tenacity, corporate knowledge and stamina takes us into the future.

PW now has lots of reasons to continue the battle on our behalf.
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juxtaposer
Posted on: Nov 30 2014, 05:36 AM


Group: Member
Posts: 153

Very well said Mrs Smith. I also took the trouble to fly to the AGM and endorse all you have said.

I spoke to 4 key people including PW and believe that we have a cracker of a team. PW emphasized how crucial it is for this team to remain as is and I had no hesitation to vote for them and reward them for the extraordinary work they have done.

I have every confidence my 10 year wait will be worth it in end. I may sell a few shares when it hits $50 but the bulk will be there for the dividends.
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juxtaposer
Posted on: Nov 4 2014, 08:16 PM


Group: Member
Posts: 153

I think this was a request of EMA at one point , topical for pediatric rather than systemic. Has this not been alluded to in recent jv statements?
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juxtaposer
Posted on: Nov 4 2014, 10:08 AM


Group: Member
Posts: 153

Keeping most for a very long time but may sell a small parcel when it goes above $30.
My early buys need to go over $8.40 to break even. Thank goodness I've been buying all the way down.
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juxtaposer
Posted on: Oct 30 2014, 01:12 PM


Group: Member
Posts: 153

I've been astounded that this major achievement in medical science has gone virtually unnoticed in the press, particularly the Australian press.
Each night I see reports on the news of "possible" breakthroughs in Australian research that in many instances are not even at phase one.

Where are our great science reporters?

As a consequence I have compiled a list of things that excite me about the future (yes a few years away in some instances) of Clinuvel.
Most particularly of interest to me is the anti-inflammatory potential of afamelanotide which is "a synthetic analog of the naturally occurring melanocortin peptide hormone alpha-melanocyte stimulating hormone (α-MSH)".

This has the potential to replace Prednisolone in many instances and with around 15 years of research behind it afamelanotide has none (EMA acknowledged) of the nasty side effects of Prednisolone. If you look through the research there are many other exciting potential uses as well.

Below is a list of links to PubMed articles that I have collected. Also a couple from Wikipedia.
Much will be old news to many on this forum but I hope will be of interest to newer arrivals and visitors.

From PubMed.....

Antimicrobial effects of alpha-MSH peptides.
http://www.ncbi.nlm.nih.gov/pubmed/10670585

alpha-MSH and and its carboxy-terminal tripeptide (11-13, KPV) were determined to have antimicrobial influences against two major and representative pathogens: Staphylococcus aureus and Candida albicans.


alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs.
http://www.ncbi.nlm.nih.gov/pubmed/17934097

"The anti-inflammatory effects of alpha-MSH have been confirmed by means of animal models of inflammation such as irritant and allergic contact dermatitis, cutaneous vasculitis, asthma, inflammatory bowel disease, rheumatoid arthritis, ocular and brain inflammation."


Role of the melanocortin system in inflammation.
http://www.ncbi.nlm.nih.gov/pubmed/17057195

In recent years, scientific interest in melanocortins (MC) has progressively increased due to their wide range of effects and expression on various tissues. Primarily discovered as mediators of skin pigmentation, recent research has shown their important roles in various body functions, such as energy homeostasis, sexual function, and inflammation. The anti-inflammatory and immunomodulatory properties discovered so far have led to the hypothesis that alpha-melanocyte-stimulating hormone (MSH) and its cognate receptors might present potential anti-inflammatory treatment options.


Targeting melanocortin receptors as potential novel therapeutics.
http://www.ncbi.nlm.nih.gov/pubmed/16488018

Melanocortins have a multitude of actions including: (i) modulating disease pathologies including arthritis, asthma, obesity; (ii) affecting functions, for example erectile dysfunction, skin tanning; and (iii) organ systems, for example cardiovascular system.

New insights into the functions of alpha-MSH and related peptides in the immune system.
http://www.ncbi.nlm.nih.gov/pubmed/12851308

Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury.
http://www.ncbi.nlm.nih.gov/pubmed/25175737


Modulation of the JAK/ERK/STAT signaling in melanocortin-induced inhibition of local and systemic responses to myocardial ischemia/reperfusion.
http://www.ncbi.nlm.nih.gov/pubmed/23535516

"These results indicate that melanocortins inhibit local and systemic inflammatory and apoptotic cascades triggered by prolonged myocardial ischemia/reperfusion, with consequent reduction in myocardium infarct size, seemingly via activation of the JAK/STAT signaling and with modulation of an ERK (STAT unrelated) signaling pathway."


Vagus nerve mediates the protective effects of melanocortins against cerebral and systemic damage after ischemic stroke.
http://www.ncbi.nlm.nih.gov/pubmed/19018269


"....melanocortins have neuroprotective effects against brain damage after ischemic stroke."


From Wikipedia

Afamelanotide

http://en.wikipedia.org/wiki/Afamelanotide


alpha-Melanocyte-stimulating hormone

http://en.wikipedia.org/wiki/Alpha-Melanoc...ulating_hormone


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juxtaposer
Posted on: Oct 29 2014, 04:49 PM


Group: Member
Posts: 153

I have been accumulating since the Epitan days and have (along with my family) added substantially (for us) this week. I am baffled at this weeks SP but believe totally in this drug, especially the safety, and have always had faith in PW and the team. Only one thing is beginning to niggle, one final little hurdle (?) the last tick of approval, ratification.
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juxtaposer
Posted on: Oct 25 2014, 03:24 PM


Group: Member
Posts: 153

Likewise for vitiligo, the focus is on darker skins but I'm just looking at my 60+ Angl/Celtic skin and in amongst the freckles and age spots live the white damage spots that CUV 9900 could help considerably. Maybe that spot of psoriasis and eczema may benefit as a side effect while I also get protection from the sun. And there is so much more in the inflammation camp to consider.
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juxtaposer
Posted on: Oct 24 2014, 10:03 PM


Group: Member
Posts: 153

Yes thanks to this community for keeping the flame of seemingly hopeless optimism alight on those dark days.
I've been an only occasional poster but often a many times a day observer and you mob have been a huge support on those days you think you are crazy but then "dam it at such a low price I gotta "BUY" -> All the way to the bottom from 0.84 (2004 cents)
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juxtaposer
Posted on: Oct 24 2014, 09:52 PM


Group: Member
Posts: 153

Only just but nothing other than the standard conditions apply.

PW and team! ........ What a sustained and gutsy effort.

This is an incredibly important new drug.

Roll on the other applications!

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juxtaposer
Posted on: Oct 24 2014, 09:29 PM


Group: Member
Posts: 153

✔️✔️✔️☝️

10 year wait.

Epitan -> Clinuvel-> Senesse.


Unconditional!


The tan is a mere side effect the main game is MUCH more important.
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juxtaposer
Posted on: Oct 24 2014, 07:47 AM


Group: Member
Posts: 153

Looks like a serious case of inflammation going on here. Anyone know a cure?
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juxtaposer
Posted on: Sep 5 2014, 01:45 PM


Group: Member
Posts: 153

Thanks to Madman for finding this via Uhoh!
http://www.hindawi.com/journals/bmri/2014/874610/

Could -MSH completely replace steroids in hospital (and elsewhere)?

from chapter 7....

The inflammatory diseases cured by -MSH can be classified into two categories. The first one comprises inflammatory disorders of the brain including traumatic head injury, cerebral vasospasm like subarachnoid hemorrhage (SAH), multiple sclerosis, meningitis, and brain reperfusion injury [29, 63]. The second category comprises inflammatory disorders of the peripheral organs, including the inflammatory bowel disease (Crohn's disease and ulcerative colitis), arthritis (rheumatoid and gout), systemic inflammation (septic shock syndrome), allergic inflammation of skin, eyes, and lungs, and reperfusion injuries of the gut and heart [29, 64]. Besides, inflammation is also one of the pathologies of several neurodegenerative diseases such as Alzheimer’s and others [63, 65]. The pathogenesis of Alzheimer’s disease (AD) involves upregulation of several inflammatory cytokines like TNF- and loss of cholinergic neurons [49, 63]. As mentioned earlier, the production of these cytokines is under the control of NF- activation, and being a potent inhibitor of NF- activation, -MSH limits the progression of AD. Furthermore, very recently, it has been reported that -MSH administration in mouse models of Alzheimer’s disease prevents the GABAergic neuronal loss and thus ameliorates the cognition [47, 52–54].

Besides anti-inflammation, -MSH/MC1R signaling plays a significant role in immunosuppression in case of allergic reactions [4]. Recently, a study uncovered the mechanism of immune-suppressive behavior of -MSH in the case of skin inflammatory diseases. It discovered that -MSH inhibits inflammation and suppresses the immune system in mouse model of psoriasis-like skin inflammation by suppressing the activation and proliferation of the effector T cells through MC1R signaling [60].
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juxtaposer
Posted on: Jun 4 2014, 03:35 PM


Group: Member
Posts: 153

This popped up today. Interesting timing.
https://theconversation.com/explainer-what-is-vitiligo-26647
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juxtaposer
Posted on: Apr 10 2014, 07:48 PM


Group: Member
Posts: 153

The really fortunate aspect of this unfortunate skin coloration side effect is the number of lives that will be saved with the inevitable demise off the solarium industry. The really unfortunate aspect is the continuing suffering of the EPP sufferers.
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juxtaposer
Posted on: May 5 2013, 08:39 PM


Group: Member
Posts: 153

Well imagined. Hope you are wrong. Is EMA subject to the same manipulation we recently heard about FDA?
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juxtaposer
Posted on: May 1 2013, 10:53 AM


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Posts: 153

Notice of change of interests of substantial holder.

M&G sees nothing plastic about SPL and increases its holding by more than 2 million shares taking it to 13.06%.
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juxtaposer
Posted on: May 1 2013, 10:31 AM


Group: Member
Posts: 153

Trading Halt!!

Capital Raising.

Attached File(s)
Attached File  01405431.pdf ( 157.77K ) Number of downloads: 116

 
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juxtaposer
Posted on: Apr 3 2013, 06:42 AM


Group: Member
Posts: 153

@ClinuvelNews: 'Young vitiligo patients support each other' http://t.co/x2DkXgqkyF
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juxtaposer
Posted on: Mar 18 2013, 06:36 AM


Group: Member
Posts: 153

Been away from the www for a bit,Here is how it looks a few hours before the ASX starts the new week.
13 buyers for 97,632 22 sellers for 89,760
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juxtaposer
Posted on: Mar 6 2013, 10:47 AM


Group: Member
Posts: 153

Yes - Thanks to all including Uhohinc.

It's been a long haul (2003 for me) but I'm finally back in front now. Not on those 2003 units but have bought all the way down and averaged the early ones away.

This is going to be a very significant molecule - way beyond it's cosmetic origins.

I'll save my biggest thank you for Mr Wolgen for saving the company when we cross the EMA line.
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juxtaposer
Posted on: Mar 6 2013, 09:12 AM


Group: Member
Posts: 153

CUV opens the ASX day with a new 52 week high of $2.75 (at 10.10 am).

17 buyers for 144,000 units v 5 sellers for 12,000 units.
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juxtaposer
Posted on: Feb 7 2013, 08:28 AM


Group: Member
Posts: 153

20 buyers for 124,689 units

16 sellers for 49,469 units
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juxtaposer
Posted on: Nov 26 2012, 09:10 AM


Group: Member
Posts: 153

?
Attached image(s)
Attached Image

 
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juxtaposer
Posted on: Nov 16 2012, 10:15 AM


Group: Member
Posts: 153

http://www.bloomberg.com/news/2012-11-14/i...s-in-study.html

Inflammation Gene Defect Linked to Alzheimer’s in Study

It's possible that CUV's anti inflammatory qualities may protect against Alzheimer's.
Those who require lifelong treatment may give us a clue at some point (EPP patients) but it will take a long time. Animal studies may offer insight faster.
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juxtaposer
Posted on: Nov 1 2012, 05:46 PM


Group: Member
Posts: 153

It becomes clearer every day that we are looking at something very big here.
A really significant game changer.
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juxtaposer
Posted on: Oct 18 2012, 08:55 AM


Group: Member
Posts: 153

Announcement
http://www.starpharma.com/news/131

Melbourne, Australia: Starpharma Holdings Ltd (ASX:SPL;OTCQX: SPHRY) today announced completion of recruitment in its two Phase 3 trials investigating VivaGel® as a treatment for bacterial vaginosis (BV).

The Phase 3 treatment trials were conducted across more than 30 international sites, and recruited 250 patients per trial. The results of the trials are expected to be available by early December 2012 - following the completion of patient follow-up, data collection and the necessary statistical analyses.

These double-blind Phase 3 studies are the subject of a formal agreement with FDA under the Special Protocol Assessment (SPA) program, which confirms that the trial design, clinical endpoints and statistical analyses are acceptable for FDA approval once complete.

Recruitment is also complete for Starpharma’s Phase 2 study for the prevention of BV recurrence. Completion of this trial is on track for Q4 2012 with results expected early in 2013.

In the meantime, an active dialogue continues with a number of potential licensing partners as do activities to support an NDA and other regulatory submissions. The required manufacturing validation and scale up activities are also now complete.

BV is the most common vaginal infection worldwide and is particularly prevalent in the US, where it affects an estimated one-third of the adult female population. Studies indicate as many as 50-60% of those women have recurrent episodes of BV and with no treatments currently approved for the prevention of recurrence of BV, that market is estimated to be in excess of $1 billion. In addition, existing treatments for BV are considered suboptimal with relatively low cure rates and high rates of recurrence, unpleasant side-effects, and high levels of bacterial resistance.

VivaGel® is a non-antibiotic gel that is not absorbed into the bloodstream (as antibiotics are), and as such it is not associated with the problematic side effects of antibiotics. Clinical trials of VivaGel® show a high level of patient acceptability and research with clinicians and patients indicate significant unmet need in the management of this disease.
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juxtaposer
Posted on: Sep 10 2012, 09:48 PM


Group: Member
Posts: 153

Great claims, very possible.
Got any published references to back em up?
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juxtaposer
Posted on: Aug 7 2012, 06:58 PM


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Posts: 153

Testing???
Interesting announcement today re agro chemicals with nufarm!
http://www.starpharma.com/news/125
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juxtaposer
Posted on: Jun 29 2012, 08:16 AM


Group: Member
Posts: 153

Melanin a ‘bio-friendly’ semiconductor
http://bit.ly/NSSHVu
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juxtaposer
Posted on: May 30 2012, 09:07 AM


Group: Member
Posts: 153

re: Jackie Fairley interviewed on ABC
http://www.abc.net.au/news/2012-05-30/star...ection=business


Particularly like that she said there was more to be gained by remaining independent rather than selling out.

Huge future...... an endless supply of off patent and currently in patent drugs/chemicals awaiting a more efficient makeover. Not to mention previously effective but too toxic drugs that may now be useable.
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juxtaposer
Posted on: May 26 2012, 11:12 AM


Group: Member
Posts: 153

Agree whole heartedly with Censere.
Dendremers = diversity on a huge scale.
This could end up being one of the biggest Aust companies.
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juxtaposer
Posted on: Mar 19 2012, 09:23 AM


Group: Member
Posts: 153

A physician I know with a very strong biomedical research background has looked very closely at Senesse.

He concluded that within the first half hour of him having a heart attack he would want to be given Sennese because of its ability to stop/repair cell death/damage.

Given its safety profile he would be prepared to have it now even though not yet approved.
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juxtaposer
Posted on: Nov 28 2011, 01:37 PM


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Posts: 153

I agree. Same conclusion I have come to.
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juxtaposer
Posted on: Nov 16 2011, 04:51 PM


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Posts: 153

Look, I think the time has come that we should show a little more kindness to Plastic.

Clearly his glass is half empty, he hasn't got very much going on in his life apart from this forum, also, from memory
he no longer holds paper and the weight of negativity weighing on him deserves a little more compassion from all.

I may be wrong, he may work for a fund that needs to keep the price down and if that's the case then again we should have pity
because the 300% rise or so over recent times may mean that he is probably unemployed by now.

Give the guy a break I think he needs it.
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juxtaposer
Posted on: Jun 27 2011, 04:36 PM


Group: Member
Posts: 153

Plastic seems to spend an unbelievable amount of time on something he doesn't like. He just keeps coming back to feed at the same bitter trough.
Is this a community service or is it just rather sad that he doesn't have a lot else to do?
Perhaps he has another agenda.
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juxtaposer
Posted on: Apr 28 2011, 12:11 PM


Group: Member
Posts: 153

I suggested this to a physician with a medical research background who responded with this....

"Interesting thoughts, but unfortunately it doesn't sound like a good idea to me. Vitamins are usually incorporated into biochemical processes. Adding them to a dendrimer would prevent that. In any case, the reason most of the supplements people take are not absobed is a deliberate ploy by the body to prevent toxicity."
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juxtaposer
Posted on: Nov 10 2010, 04:40 PM


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Posts: 153

Slides 20-23 in the presentation make me not only agree with you that I won't be selling but also make me VERY VERY VERY excited about the road ahead.
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juxtaposer
Posted on: Oct 19 2010, 10:57 PM


Group: Member
Posts: 153

And Starpharma (SPL) has been climbing nicely last 2 days as well.
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juxtaposer
Posted on: Oct 11 2010, 12:13 PM


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Posts: 153

Apologies for scaring the horses. Written at speed over breakfast.

Of course there is no proposal for a capital raising and I would hope like hell there isn't one.

I was carrying in my head some discussions with other holders off line re a possible issue and also Duckwin's remark about his concerns on this. Also extrapolating Cencere's comments re the Ventacor fiasco.

What I meant to say was that if there was the need then I would be a reluctant supporter. Bring on the Italian money and approval!
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juxtaposer
Posted on: Oct 11 2010, 07:32 AM


Group: Member
Posts: 153

Excellent analysis and does bring a voice of reason to the discussion.

There is no doubt that we have a very safe and very effective product here.

Given the appearance of CUV9900 we also have a lengthening life before IP runs out.
With what has been reported by people on the trials re arthritis and psoriasis there are sure to be a number of further products to be listed for approval. The anti-inflamitory aspects are extremely exciting.

Despite the frequently vented frustrations of speculators about management here I agree with Censere that we have real quality in PW personally I believe he has done an extraordinary job since Epitan. Comments re PW not buying market do not make sense. Why would he with so many options sitting in the cupboard. He has bought on market once and that was to support the falling share price.

Censere's mention of Ventracor's demise is VERY important for those of us hanging on here. Essentially the shareholders were blinded by their own greed and the company went south. Let's not commit suicide in the same way.

I reluctantly support the capital raising because it is essential to get us through the next phase and ensure the continuing exciting developments do not fall out of our hands.

Censere makes scenesse.
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juxtaposer
Posted on: Sep 26 2010, 03:51 PM


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Posts: 153

BV Phase II study to be completed December

http://clinicaltrials.gov/ct2/show/NCT0120...arma&rank=1
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juxtaposer
Posted on: Sep 9 2010, 06:50 PM


Group: Member
Posts: 153

B!

This is only the BEGINNING.
New peptide announced, how many more to come?
Not much mention yet of the anti inflamatory properties.

(first bought in 2003, been adding as the sp drops.)

NOT going to sell for peanuts, ie $9.75.
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juxtaposer
Posted on: Sep 5 2010, 04:32 PM


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Posts: 153

Surmodics where the Sceness is being made has a patent that was filed earlier this year for nasal delivery of drugs including MSH!

more on the Yahoo Forum...
http://messages.finance.yahoo.com/Stocks_%...4&frt=2#620
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juxtaposer
Posted on: Sep 4 2010, 06:07 PM


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Posts: 153

Here's an interesting and much more positive take on the current situation from the Yahoo Forum....

http://messages.finance.yahoo.com/Stocks_%...frt=2&off=1
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juxtaposer
Posted on: Aug 26 2010, 07:19 AM


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I read "by 2011" a liitle differently. Doesn't that mean it will be done BY 2011 not IN 2011?
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juxtaposer
Posted on: Jul 27 2010, 09:37 PM


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Posts: 153

This one might not be such "a long way off".

The future for many is obesity and diabetes, sad but true. For many including smokers this may mean amputation of a limb due to poor or no circulation in the far end of the vascular system.

Over 1000 limbs are amputated daily world wide.

An Australian surgeon has invented a device that pumps blood to this region and has already saved a number of limbs with patients returning to a much better life than they have been suffering. Saving limbs and precious health dollars.
This device has about 18 months to go in its trials.
A second use has been identified and received CE marking approved as a repeated access catheter.

ASX code AMT
http://www.asdm.com.au/products/vascular/p...l-access-device
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juxtaposer
Posted on: Jul 27 2010, 06:32 PM


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Posts: 153

Having met a fund biotech analyst I realised just how little these guys know. No credentials other than financial. No real hope in understanding the science. Au brokers/advisors know mines and energy. Many have been burned on biotechs before- safer to avoid them until they become COH or RES and they can get real numbers to make fancy charts. Of course by then they have missed the first explosive moment.
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juxtaposer
Posted on: Jul 21 2010, 10:32 PM


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Posts: 153

The active ingredient in the recently publicised gel is tenofovir - a drug used in tablet form that commonly forms part of a treatment regimen for HIV infections. Like all HIV medications, it is not without side effects and some of these are chronic side effects. Some of these (such as osteomalacia) may have significant implications for young, healthy people who may use this gel to prevent HIV transmission during sexual intercourse. Studies are under way to look at the development of such side effects.

This, and other studies examining the systemic use of tenofovir (ie tablets) to prevent HIV transmission, leads me to believe that widespread use of these products (if further studies confirm that they prevent HIV transmission) will only occur amongst groups that have an extremely high risk of acquisition of HIV. In other words, for the risks of the preventative medications to be worthwhile, the risk of contracting HIV must be high. This is not the case in the developed world. Therefore, I believe that gels based on existing HIV treatments will only find practical application in countries with a high background prevalence of HIV: the developing world.

Non-toxic methods of preventing HIV transmission will be the only form that finds acceptance in the developed world (so long as the prevalence of HIV remains relatively low as compared to developing countries).

Therefore, Vivagel is still VERY much in the game.
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juxtaposer
Posted on: Jun 18 2010, 06:13 PM


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Posts: 153

7.5 million shares bought for 0.50c today by someone. That's a 5 cent discount on current SP.
Orbis has increased it's holding 2.5 million.
Is just June 30 fiddling or is something going on here?
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juxtaposer
Posted on: Jun 4 2010, 12:54 PM


Group: Member
Posts: 153

I first started buying into this in 2003 and will not be selling anytime soon. This is looking more exciting by the day. Very well run company, game changing product with potentially many applications. The emphasis on safety, safety, safety is very impressive.

As the rest of the market wobbles up but mostly down small biotecs with great products in the pipeline may be one of the few ways to go against the tide of doom.

Here's a couple of my favourite hopeful Black Swans of the future that I'm sitting on in addition to CUV.

AMT
A ground breaking treatment regime that uses high pressure perfusion of a diseased limb to stimulate collateral growth and increase flow to the peripheral vessels. This new treatment has been trialled with a high success rate.

See todays ASX announcement http://www.asx.com.au/asx/statistics/displ...;idsId=01069535

SPL
Starpharma
http://www.starpharma.com/

TEO
This little sleeper has a VERY interesting board and revolutionary peripheral catheter being trialled in the USA.
http://telesso.com/investor_relations/Tele...R_low%20res.pdf
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juxtaposer
Posted on: Jun 4 2010, 12:25 PM


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Posts: 153

Major AMT announcement to ASX today (not yet on the website) , see below......

SYDNEY 4 June, 2010 - Leading Sydney medical device design, manufacturing and marketing company, Advanced Surgical Design and Manufacture Limited (ASDM) (ASX: AMT), announced today the discharge from hospital of the first of the clinical trial patients being treated for advanced peripheral vascular disease (PVD) resulting in gangrene of the leg.
The treatment, using the PAD device developed at ASDM, is aimed at improving the circulation in threatened limbs so as to avoid amputation of the limb. Approximately 10 legs are amputated each day in Australia alone as a consequence of vascular disease usually caused by diabetes and smoking. The first patient would have otherwise had his leg amputated above the knee. He is now without pain and his leg ulcers are healing according to the operating surgeon, Prof Rod Lane. Professor Lane also went on to say that success in this patient was “amazing as he was an extremely severe case of peripheral vascular disease with extensive ulcers and had already lost half of his foot to gangrene”. The patient will now undergo rehabilitation to restore his mobility and lifestyle.
Recruitment for the trial, which will run over the course of the next year, continues and patients are expected to commence treatment in the near future. The trial will test the effectiveness of the treatment in preventing amputation, as well as establish clinical evidence for CE mark approval at Class III. The device already has Class IIa CE Mark approval for its use in isolated organ treatment of cancers.
Dr Roger CEO & Managing Director of ASDM said, “The potential for this treatment is incredible on several levels. Firstly, these patients are relieved of terrible pain, not to mention the suffering as a result of limb amputation. Secondly, this treatment will potentially save the health budget millions of dollars in costs of ongoing care and the costs of amputation. Finally, the successful commercialisation of this device will result in a significant return for investors in ASDM.”



How many diabetes sufferers are there in the world who could benefit from this? How much money will it save the health system
Website
http://www.asdm.com.au/home
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juxtaposer
Posted on: May 26 2010, 10:48 PM


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Posts: 153

Sure "tanning is the elephant in the room" that's interesting but nobody seems to be talking about Scenesse's amazing anti inflammatory properties and it's potential other uses, perhaps with heart disease among many others.

Why did those guys in Italy jump the gun on the rest of Europe? Could someone there be looking at some high status publishing of research ahead of the pack?

Just speculating.

Once it is approved and on sale in Europe how long is it likely to take to get it approved for other very useful purposes (cardio, psoriasis etc) other than tanning?
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juxtaposer
Posted on: Jan 27 2010, 09:43 AM


Group: Member
Posts: 153

Ah yes the nervous Nellies are scampering!
Bring on 19 cents and I'll double my holding.

Maybe it was that Japanese study that doesn't amount to a hill of beans for CUV that got them scared.
Everyone has tan as the most important thing for CUV but what about its anti inflammatory qualities, maybe that is as big or bigger.

Come on drive the price down more .... I want to buy!
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