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CUV, CLINUVEL PHARMACEUTICALS LIMITED
macgyver
post Posted: Today, 07:43 PM
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In Reply To: Dr Wally's post @ Today, 06:25 PM

QUOTE
“a disaster waiting to happen” could likely cause unnecessary safety concerns for the others Scenesse in particular for absolutely no reason whatsoever so its fkng stupid gibberish, and for what reason?


I have to laugh when I look at this sentence. Its very dramatic.

 
macgyver
post Posted: Today, 07:28 PM
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In Reply To: Dr Wally's post @ Today, 05:36 PM

The problem is not the drug, its the marketing and application that's the problem. Capped off with a dumb name to boot. The disaster in question is that Vylessi will have low sales, and I think Spana is misreading the landscape regarding what women want and that perhaps there's more to it than taking a drug?

They're not commercialising it very well IMHO. Surely there must be some other indication they could've gone after with a more robust efficacy score and/or orphan status perhaps? Seems to me they just wanted to get it out there, or rather Carl Spana is no PW and didn't know what the hell to do with it. Perhaps he just wants it go off label pronto...

 
Dr Wally
post Posted: Today, 06:25 PM
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In Reply To: waz's post @ Today, 05:56 PM

“”Nope. Different peptide. Brem is not even MT2. It is a derivative.””


Yep! That’s what I said.

“” (extremely similar to Afamelanotide/MT2)””


“”Bremelanotide is an active metabolite of melanotan II that lacks the C-terminal amidegroup.[17]

Aside from melanotan II and endogenous melanocyte-stimulating hormones like α-MSH, other peptide analogues of the same family as bremelanotide include afamelanotide (NDP-α-MSH), modimelanotide, and setmelanotide.””

All of these peptides are incredibly similar so calling one out as being suspected of being “a disaster waiting to happen” could likely cause unnecessary safety concerns for the others Scenesse in particular for absolutely no reason whatsoever so its fkng stupid gibberish, and for what reason?



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“” The discovery of the endogenous melanocortin agonists in the 1950s have resulted in sixty years of melanocortin ligand research.””

The never ending quest to have Afamelanotide (peptide) (SEMI) accepted for its potent ability to stimulate a natural photoprotective,cancer preventative, therapeutic “tan” was (SEMI) accomplished in 2019.

Regulator ignorance, bias, and stubborn resistance to Scenesse are the primary reasons behind this glacial journey. The evidence should be clear to all by now.
 
waz
post Posted: Today, 05:56 PM
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"Will the disaster your calling out concerning Brem have implications for Scenesse??"

Nope. Different peptide. Brem is not even MT2. It is a derivative.

FWIW, MT2 was handed back to Competitive Technologies by Palatin as part of a legal agreement which resulted in Palatin paying US$800k to Competitive Technologies over their Brem derivative.

In response to macgyver, would be interesting to understand current status of MT2. Probably close to being out of patent and CUV would do well, perhaps, by taking it over if still available.


Said 'Thanks' for this post: macgyver  
 
Dr Wally
post Posted: Today, 05:36 PM
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In Reply To: macgyver's post @ Today, 08:23 AM

“”I’m calling it now, Vyleesi is a disaster waiting to happen, and while it’s trying to address an important issue it’s the wrong drug to do it with.””


Really? On what possible evidence are you claiming Bremelanotide (extremely similar to Afamelanotide/MT2) is a disaster of some kind?? Just waiting to happen??


Will the disaster your calling out concerning Brem have implications for Scenesse??


I know theres not much happening right now (that we know about ) but do we really need any more hysteria concerning these now FDA approved safe drugs?


You should know better Mac seeings you’ve been privy to a tonne of inside information here over many years


it’s the wrong drug to do it with.”” ???


Where do you get this baseless BS from Mac Daddy?

666 devilsmiley.gif



--------------------
“” The discovery of the endogenous melanocortin agonists in the 1950s have resulted in sixty years of melanocortin ligand research.””

The never ending quest to have Afamelanotide (peptide) (SEMI) accepted for its potent ability to stimulate a natural photoprotective,cancer preventative, therapeutic “tan” was (SEMI) accomplished in 2019.

Regulator ignorance, bias, and stubborn resistance to Scenesse are the primary reasons behind this glacial journey. The evidence should be clear to all by now.
 
waz
post Posted: Today, 04:32 PM
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Shorter re-loading the ammo, trying to borrow more stock..

 

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macgyver
post Posted: Today, 08:23 AM
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In Reply To: endymion96's post @ Today, 06:54 AM

Who would’ve thought getting your horn on would be so procedural wub.gif

I’m calling it now, Vyleesi is a disaster waiting to happen, and while it’s trying to address an important issue it’s the wrong drug to do it with. Carl Spana should be fired. Or Clinuvel should do a hostile takeover and bring another melanocortin under its umbrella. And it’s a dumb name for a drug. Khalessi meets Viagra thumbdown.gif

 
endymion96
post Posted: Today, 06:54 AM
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In Reply To: sharelooker's post @ Feb 15 2020, 09:12 PM

No that is just first-time users experiencing side-effects. They tend to lessen with use. The reason is too much drug at once. I've said this for years ... these side-effects can be mitigated. If you really want to use Vyleesi correctly without much side-effects, you would first load up with small doses to get your body used to the drug, then use the full amount in auto-injectors. Doing it fresh, having never tried it, is bound to bring these kinds of reactions.

 
mrdax
post Posted: Yesterday, 11:28 PM
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In Reply To: investek's post @ Yesterday, 07:12 PM

Interesting that a Mr Langsam, which translates to "slow" in German, speaks about PW 🤷🤣

 
sharelooker
post Posted: Yesterday, 09:41 PM
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Dr Boreham’s Crucible: Why CSL is the poster child for most junior drug developers
https://stockhead.com.au/health/dr-borehams...rug-developers/

QUOTE
So how do you pick the next CSL? You probably can’t, although holders in the runaway $1.3bn drug developer Clinuvel (ASX:CUV) may feel they are onto the next big thing
biggrin.gif





Said 'Thanks' for this post: Clinhope  Farleap11  blackm3  nipper  waz  G dawg Delaney  
 
 


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