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CUV, CLINUVEL PHARMACEUTICALS LIMITED
macgyver
post Posted: Today, 08:35 AM
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In Reply To: andymen's post @ Today, 07:39 AM

That’s what I was thinking. Maybe we need Carl Icahn to come down and shake things up at Clinuvel😬


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seeva222
post Posted: Today, 08:04 AM
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In Reply To: andymen's post @ Today, 07:39 AM

I believe he has a balance sheet target. But that makes no sense in this case is every dollar spent would come back many times over.

 
andymen
post Posted: Today, 07:39 AM
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In Reply To: Johnny H's post @ Today, 06:47 AM

I have been thinking lately, that perhaps the reason PW keeps a the $$ in the bank is to make CUV a more attractive T/O target.

Just speculation on my part.

 
Johnny H
post Posted: Today, 06:47 AM
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In Reply To: seeva222's post @ Today, 04:09 AM

I'm told that having no debt is the greatest achievement in the history of mankind.



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Clinuvel until my bowels release for the last time.

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seeva222
post Posted: Today, 04:09 AM
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In Reply To: Johnny H's post @ Yesterday, 09:51 AM

Every day they lose dollars: $250k a day, $1.5M a week, $7.5M a month.

*This assumes there are 1000 patients at 15K getting treatments every 2 months.




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Johnny H
post Posted: Today, 01:38 AM
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In Reply To: Justinian's post @ Yesterday, 01:39 PM

In some of the interviews I've seen with US EPP patients, some of them are so sensitive to light that they'll have a painful reaction indoors to the wrong kind of lightbulb. Their sensitivity isn't to seasonally & latitude dependent UV light, It's to nearly ubiquitous blue light (450–495 nm). Eumelanin happens to filter both.

One patient, who spoke about her EPP at Yale Medical Center in honor of Rare Disease Day 2018, had to conduct the presentation with the lights turned off in the classroom because she could feel a reaction starting. The room had no windows. This same patient was able to go to the beach on a sunny day while on Scenesse.

While there are a few milder cases of EPP where the patients might limit their treatment to 4x a year when they're most likely to be outdoors, there are many patients who, regardless of the climate where they live, will absolutely will need treatment 6x a year just to be able to take the sheets down from their bedroom windows.

I don't recall the exact reason that the EMA gave for recommending 4 implants per year, but it's absolute rubbish. They might have claimed that there was a valid medical basis for their decision, but there isn't. It's quite obviously a cost-saving measure. The FDA doesn't consider cost of treatment in their decision making process, and their assessment contains no such restrictions.




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Clinuvel until my bowels release for the last time.

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Justinian
post Posted: Yesterday, 01:39 PM
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In Reply To: oystercatcher's post @ Yesterday, 01:09 PM

I would think a lot of the US would need treatment some of the winter. The latitude in Florida lines up with North Africa. Most northern states line up with with south Europe.

 
Frogster
post Posted: Yesterday, 01:13 PM
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In Reply To: Johnny H's post @ Yesterday, 09:51 AM

Don't worry Johnny, I'm sure with the wealth of recent US commercial pharmaceutical experience they have on the Board that the tardiness in getting the product to patients and making sales is all part of what will come to be described by said Board in due course as "a perfectly conceived and executed launch plan".



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Dr Wolgen is a magician.
His end game for Scenesse will impress, or even amaze.
En route, along with glimmers of truth, there will be distractions, illusions, sleight of hand and misdirection.
Enjoy the ride.

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oystercatcher
post Posted: Yesterday, 01:09 PM
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I live in Brisbane Australia so this question might seem elementary to some. Some past posts have suggested that US EPP suffers will only need to have implants in the warmer months. How about the 10 USA states that enjoy mild winters. Wouldn’t they want an implant all year protection?

 
Johnny H
post Posted: Yesterday, 09:51 AM
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In Reply To: Desert Rat's post @ Yesterday, 05:52 AM

US patients theoretically have access to 6 implants per year. 6 x 60 days = 360 days, or pretty much the entire year.

Every day that Scenesse remains unavailable is another day that Clinuvel loses money.

If Clinuvel had been ready to distribute at approval, most US patients would be halfway through their 2nd implant by now. That's quite a missed opportunity, both financially and for the patients who have been patiently waiting in the dark.



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Clinuvel until my bowels release for the last time.

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