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endymion96
Posted on: May 8 2020, 06:26 PM


Group: Member
Posts: 409

Time invested is "forcing" me to hold and also the potential which I know is there. Its not potential in the respect that I hope it works, but rather its the potential in that I know it works and management is moving to slow to demonstrate its potential to the world. The potential I'm waiting for is exposure. That is why I hold. I will give credit to management for dealing with the regulatory process. That was a b*tch. We were all hoping that after FDA approval was obtained, management would change their style a bit. It is happening ... but this last letter was a bit much. We longs deserve a little more respect.
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endymion96
Posted on: May 8 2020, 05:58 PM


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Posts: 409

Afamelanotide treats all those inflammatory pathways and more. The last paragraph states exactly what I have been saying. You need a combo drug cocktail for critically ill COVID-19 patients. One drugs stops the replication and the other dampens the inflammation. I will be writing a full on summary of my findings very soon. It will be a more meaningful attempt at garnering support for the idea that afamelanotide could be a miracle drug in more ways than some of you can grasp. And also to slap back at the dummies who think this is just some armchair quarterback who is just throwing darts. I try not to make statements unless I have first done my research.
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endymion96
Posted on: May 3 2020, 10:46 AM


Group: Member
Posts: 409

I think I got one thing wrong in my post and its too late to edit so I'm adding on here. When Angiotensin-II unites with the ACE2 receptor, it causes blood pressure to rise through vasoconstriction. The way blood pressure is reduced is by decreasing Angiotensin-II. Thus, less binding to ACE2 causes the smooth muscles of the blood vessels to relax and dilate. With COVID-19, all it does is replicate and bind to ACE2. So that is what causes vasoconstriction on a systemic scale. However, by blocking Angiotensin-II from binding to ACE2, COVID-19 is also preventing the transformation of Angiotensin-II into Angiotensin-1,7, which is necessary to reduce the number of superdioxides (ROS) in the body. So oxidative stress increases as a result.
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endymion96
Posted on: May 3 2020, 10:11 AM


Group: Member
Posts: 409

odi01, yes I too believe that Afemelanotide could be used as an anti-aging drug because of its anti-oxidation effects. When DNA is replicated in the cell, mistakes can sometimes be made by the cell replication machinery due to free-radicals coming in and messing up the chain. Each time these mistakes happen, if the happen to occur at the ends on the DNA strand, they are never repaired but cut-off instead and a shortened version of the DNA lives on. Over the course of your life, this continuous shortening of DNA eventually leads to problems in old age, typically cancer. Cancer occurs when cells no long function properly. The DNA is no longer providing the secret sauce to keep you young and healthy. If Afemelanotide can truly repair DNA at a young age, it could slow down the process of aging because it would allow the DNA to retain all of its information. At least, this is my understanding of how it will work.
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endymion96
Posted on: May 3 2020, 09:50 AM


Group: Member
Posts: 409

You can say whatever you want ... morons typically do that. Find me another BAT-SARS Coronavirus that has no less than 4 inserts of HIV-1 inserted into the genome dumbass. There are many BAR-SARS viruses. Find me just one. I'll be waiting while you sit on your thumbs again. If you want I can list many of them for you to give you a jump start. Let me know.
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endymion96
Posted on: May 3 2020, 09:41 AM


Group: Member
Posts: 409

Concerning blood pressure ... and my thought that Scenesse could be the miracle we need to fight COVID-19, here is the latest ... it appears that this virus is a blood-related virus more than it is a respiratory virus. While true, the virus must enter through the respiratory airways to infect and it does get into the cells of the lung and cause damage, its main source of inflammation is via the endothelial cells of the blood vessels. This is what causes the inflammation in the lungs and mucus to build up. Its main mode of attack is via the ACE2 receptors found in a large variety of cells in the body ... lung, heart, kidney, liver, brain, prostate, gut, you-name-it. These same cells also express MCR-1.

What causes some people to have more disease related illness than others seems to be due to their individual levels of oxidative stress. In a study of 5700 patients in New York, surprisingly only 5% of people in that population had COPD or respiratory problems. Far more prevalent were people who had co-morbidities like hypertension, diabetes, obesity, and cardiovascular disease. I think the percentage was 39% of the total. All of these issues cause oxidative stress. Therefore, when you are already at risk, COVID-19 might just push everything over the edge.

What happens is that normally, the ACE2 receptors bind to a peptide called Angiotensin II. Let me explain that process first. The liver releases the precursor molecule Angiotensinogen into the blood stream where it gets processed by the Kidneys to produce the peptide Angiotensin I (this is the first part of the process). The process is completed in the lungs where Angiotensin I is turned into Angiotensin II. This peptide then binds to the ACE2 receptors where it regulates blood pressure. The effect of the binding causes the blood vessels to dilate (i.e. expand) and blood pressure to drop.

Because the virus is also attacking at the point of ACE2 and blocking normal function of Angiotensin II, the normal way of controlling blood pressure is cut off. So what starts to happen is that the blood vessels start to constrict causing blood pressure to rise. When Angiotensin II normally binds to ACE2, it transitions to another form called Angiotensin-1,7. This form of the peptide is what helps to bind with superdioxides to remove the class of chemicals known as radical oxygen species (ROS) from the blood. Because this pathway is not happening, ROS starts accumulating. If the patient is already undergoing oxidative stress due to co-moridities, then he/she is going to be in big trouble.

The body has other ways of dealing with oxidative stress, but some of those pathways are also blocked by the virus. This leads to inflammation throughout the body. In addition, the virus attacks the lymphocyte system (white blood cells) through a receptor called CD147. When this happens, normal leukocytes (T-Cells) become disabled and are thus, not able to recognize the virus and disable it. The count of Neutrophils also goes up because of the large amount of inflammation. This leads to an overabundance of cytokines released by the body and causes more inflammation.

Lastly, because the endothelial cells are affected, this causes a cascade which releases clotting agents into the blood stream causing coagulation. Since the virus has blocked Angiotensin II from binding to ACE2 and has caused vasoconstriction, this leads to blood clots and strokes. Kidney failure is also a significant problem along with respiratory problems.

The main takeaway is that the CCP virus is now known to cause its damage by up-regulating the effects of oxidative stress (release of free radicals) into the blood stream. Any potential cure must address something in the pathway that fixes this problem. We probably cannot prescribe ACE2 blockers because we would still be in the same situation of blocking the action of Angiotensin II. I believe a cure will have to effect the way the virus replicates. If replication can be stopped, then ACE2 will not become choked off by virus attachment. Any treatment that can help scavenge free-radicals, superoxides (ROS) will also be valuable. I believe that Scenesse could be key to combating oxidative stress an over-inflammation. It performs both functions extremely well. It is a known scavenger of free-radicals and it is known to reduce inflammation, primarily by down-regulating NF-kB as I stated in an earlier post but also by reducing cytokines such as IL-6 which are prevalent in the disease.

https://www.thelancet.com/journals/lancet/a...0937-5/fulltext
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endymion96
Posted on: Apr 30 2020, 07:37 AM


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Posts: 409

ZINC is key to these treatments. HCQ is an ionophore for ZINC, meaning it allows ZINC to be absorbed through the cell wall. Once inside ZINC blocks the formation of the polymerase enzyme and prevents the virus from replicating. Some people may be taking ZINC supplements and others not; therefore, a full blood panel should be used in these "studies" to find out the baselines for each person. Obviously, some may respond to HCQ better than others because they may be taking a multi-vitamin containing ZINC? Who knows. But I can show you an NIH study that employed HCQ and high levels of ZINC in vitro and was capable of disrupting the replication process of Coronaviruses. Anybody wants it, I will post.

Therefore, these so-called "studies" which are not also employing ZINC in their treatment are going to have worse results then with HCQ alone. However, HCQ does have some other effects which are helpful in slowing down the virus. For instance, HCQ changes the structure of the cell wall to make it somewhat less permeable to the virus. The virus gets in through the cell wall by attaching to the ACE2 receptor. Once that happens, a cascade effect occurs which brings it in. If you can stop this process or slow it down, that is half the battle. HCQ and other related ZINC ionophores like Quercetin (which you can buy over the counter) do this. Another way HCQ helps is by lowering the PH of the environment inside the cells making it more acidic. In general, viruses do not like acidic environments and they will not replicate very effectively. A third way HCQ helps is by somewhat altering the shape of the ACE2 receptor making the binding affinity of the virus less potent. OK, so there is indeed a wealth of information regarding how anti-malaria drugs can be used to combat the virus. But, to be the most useful, HCQ+ZINC must be given early on when symptoms first start appearing. I defy anybody here to show me a drug that works its best when the patient has already gone into a cytokine storm and is experiencing the deleterious effects of an over-excitation of the body's inflammatory response. There is only one drug I can think of right now that might help with that situation ... Scenesse.
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endymion96
Posted on: Apr 30 2020, 06:55 AM


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Posts: 409

I just presented you with the peer-reviews!!! You obviously dismissed the information I presented without studying the videos. Admittedly, it may take you a good 2-3 hours to get through them, but if your conclusions are guided by taking in all sides and not by pre-conceived notions based on an internal bias, the you should go back and review.
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endymion96
Posted on: Apr 30 2020, 06:53 AM


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Posts: 409

This report references the Veteran's Administration study which I was referring to ... the exact study which was just debunked by no less than three seperate medical doctors for which I provided 3 separate videos. Did you just reflexively post this as a refutation or did you actually watch the videos I presented? The video you presented is simply a reporter who is regurgitating the party line. I challenge you to watch the videos first before drawing a conclusion from a reporter who knows nothing about science or how scientific studies are conducted.
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endymion96
Posted on: Apr 30 2020, 06:48 AM


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Posts: 409

If you are not a dumb troll, why don't you explain your "garbage" comments instead of tossing grenades around. Explain to me and the rest of the board members here why you think the science explained in the videos is garbage? If you can't or come back with some asinine comments, I advise others to dismiss anything you have to say in the future.
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endymion96
Posted on: Apr 29 2020, 05:50 AM


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Posts: 409

I just can't say enough about Dr. Seheult. He is one of the best. Here is his latest video. However, please watch these videos from the bottom up in order to follow along. That means start with the initial 3 below in the group and then watch upwards.

https://youtu.be/DtPwfihjyrY
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endymion96
Posted on: Apr 29 2020, 05:37 AM


Group: Member
Posts: 409

If you want to understand the "how" and "why" strokes are happening with seemingly healthy patients stricken with the CCP virus, watch this video presentation by Dr. Seheult.

https://youtu.be/22Bn8jsGI54
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endymion96
Posted on: Apr 29 2020, 05:15 AM


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Posts: 409

NOTE: HCQ has been effectively and safely used since the 1950's to treat diseases such as malaria, lupus, and rheumatoid arthritis. Its safety profile is well known and has a much wider range than its forerunner Chloroquine. Chloroquine has a VERY narrow margin of safety. Any dosage that strays outside of this safety range can kill you ... as evidenced by the Darwin Award winners who drank fish cleaner because it had CQ in it. The lying media has used stories like this and studies like the Veterans Administration (UVA medical) to twist the common perception of HCQ. By the way, UVA was receiving a grant to study another COVID-19 treatment in the works, so there is a huge possibility of conflict-of-interest in pushing out a non-peer-reviewed study on HCQ for the dishonest media to pick up and report.
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endymion96
Posted on: Apr 29 2020, 05:03 AM


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Posts: 409

COVID-19 attacks many cells in the body because many cells present a way for the virus to be absorbed into the cell, chiefly through the ACE2 receptors. But as the virus mutates (it was designed that way by CCP, called "gain of function"), it is learning how to find its way in through other receptors as evidenced by its affect on leukocyte cells (using a different receptor to penetrate and disable T-Cell function). The virus has 4 parts of its genome where HIV-1 bits were inserted. So it will behave in a way that is AIDS-like. Trust me, you do not want to catch this virus because it is yet to be determined whether any long-term affects will occur. We have already started hearing of people who had the virus and supposedly were cleared of it suddenly show symptoms again weeks after being "clean". In my estimation, the virus lies dormant in certain parts of the body and then reactivates under stress or some other signal and starts its replication again. We shall see. I am doing more research on this and will let you know if I come across anything.

https://www.reuters.com/article/us-health-c...0E1Vp4Kg5UHfMoY
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endymion96
Posted on: Apr 29 2020, 04:52 AM


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Posts: 409

It shouldn't be surprising to anyone by now that the several "studies" on the use of HCQ are purposely being put out to misinform the public. The original study showing the great results in France by the reknowned Virologist, Dr. Didier Rauolt, has been expanded to 4600 patients and has had fantastic results. These same results are being repeated in countries such as Brazil, Honduras, Costa Rica, China, South Korea, and parts of the USA where doctors are correctly prescribing the cocktail with ZINC. The other studies panning the use of the drug use bits and pieces of the truth and do NOT include ZINC ... as a way of pushing a certain propaganda narrative. Now, I do not know if this is to discredit President Trump's initial suggestion to try HCQ as something that should be looked at (due to Dr. Raoult's work) and/or if it is Big Pharma attempting to put out a certain perception of the drug so that people and doctors shy away from its use? Afterall, Big Pharma stands to gain trillions of dollars if they can push their $1000 a pop treatments on the public vs. a $12 dollar alternative whose patent expired decades ago. I leave it to you smart readers to discern the truth after watching the following peer-reviews of the latest "study" on HCQ. Do not comment until after you have watched all 3 videos.

https://youtu.be/JUvs_cqZDwc

https://youtu.be/fn2yk5SbGiw

https://youtu.be/dLSYRqcg0wo


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endymion96
Posted on: Apr 28 2020, 03:41 PM


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Posts: 409

I want to point out one other thing. Those two doctors whose skin darkened due to a-MSH not being processed by their damaged livers. Could this effect be due to the body trying to heal itself via all the pathways that a-MSH opens up? I think the answer is yes. Its a natural defensive response, not just some freaky side-effect of a disease.
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endymion96
Posted on: Apr 28 2020, 03:27 PM


Group: Member
Posts: 409

Yes, bingo! You are starting to see the potential that I saw a few weeks ago. COVID-19 doesn't just attack lung cells. Its attacking cells all throughout the body because so many of these cells present the ACE2 receptor. COVID-19 is also attacking the leukocytes and disabling them. That is how the virus is able to replicate asymptomatically for so long without seeing an immune system response. Once replication gets out of control, that's when symptoms appear, but by then it has done major damage. It does not take long from that point in time until your body mounts an inflammatory response. Then comes the cytokine storm and its game-over. If the patient gets to that point, he/she needs Afemelanotide to down-regulate the inflammatory response while anti-malarial drugs like HCQ+ZINC stops the virus replication. This is the whole ballgame on how to treat serious/critical patients.

There is nothing on the horizon that can do that right now. Even the anti-viral drugs they are developing are of no use once the virus has replicated and overtaken the immune system response because it has attached to most cells already ... there are no more receptors for the inhibitor-type drugs to attach to and block the virus. At that point, it has cornered the market and the body becomes inflammed. People are dying from kidney failure, liver failure, heart failure, blood clots, brain damage, etc ... once the patient reaches a certain point, we need to counter-act the inflammation response and the body's over-reaction. So we need afemelanotide to do that. Then we need HCQ+ZINC to stop the virus replication while we get the inflammation under control. If there are neurological problems, MT-II might be better, but generally activation of MCR-1 should work well.
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endymion96
Posted on: Apr 28 2020, 02:59 PM


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Posts: 409

So here is another example where a-MSH down-regulates NF-kB and could potentially make stroke damage less severe. I pointed out several days ago that NF-kB was the key to fighting COVID-19 as well.
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endymion96
Posted on: Apr 27 2020, 04:07 AM


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Posts: 409

Here's a strange phenomena, COVID-19 is apparently causing a darkening the skin through a cascade of effects. A Chinese doctor says that this is due to extensive liver damage which causes iron to release into the blood. Apparently when this happens, a-MSH cannot be processed by the liver and is allowed to flow through the blood as well. Either this is the case or these COVID-19 patients are being treated with an a-MSH hormone of some type?

Article regarding liver cirrhosis:
https://www.cirrhosis-treatment.net/skin.html

Youtube video showing patients with darkened skin:
https://youtu.be/PZ_yvztyMxw
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endymion96
Posted on: Apr 27 2020, 03:31 AM


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Posts: 409

FYI - IRS deadline is July 15th for federal taxes, but state taxes may be owed sooner. In my state, the deadline is June 1st.
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endymion96
Posted on: Apr 26 2020, 12:54 PM


Group: Member
Posts: 409

So I went on a little archeological dig and looked back into the forum posts for the answer. If you start around page 3856 and work backwards to 2008-12-31 you will find people commenting on the (then) current trading range. I found one person who purchased 100,000 shares on Christmas Eve 2008 for 0.195 AUD - this was apparently a score becuase the price was climbing at that time. Later, another poster said that by 2009-01-03 the trading price was 0.265 AUD and the ADR (CLVLY) was going for 1.90 USD. So I figure, with the exchange rates back then, that's the 10-to-1 reverse split pricing and market equilibrium price as close as I can find it. If that is true then the exchange rate back then was 1 USD = 1.44 AUD which is 0.71 USD? So, I did further research and found this website (shared below) that records historical exchange rates. The rate they have for 2009-01-03 was 1.00 USD = 1.435 AUD which is 0.70 in USD, so bang on! Thus, I'm going to use 1.90 USD as my cost basis per share based on the 2008-12-31 "born-on" date in my stock data for my taxes.

http://www.exchangerateusd.com/historicale...02#.XqTzJS8pC-o

NOTE: Way back then, Polyphemus wrote (I forget the page number 3856?) in a post that the CLVLY was created in March 2006, so that must have been when Epitan became Clinuvel. I'm sure others know this for sure. I've been invested so long, I can't even remember the history any more!

UPDATE: On 2006-03-01, EPTNY became CLVLY according to Polyhemus on page 3858.
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endymion96
Posted on: Apr 26 2020, 09:57 AM


Group: Member
Posts: 409

Doing my taxes, got a question I don't know how to answer, maybe somebody can help. I sold shares of CLVLY in 2019. When I imported my data, it showed 0.00 as the cost basis for the sold shares so its basically using the full freight of sale ... obviously that ain't right. I need to come up with a cost basis for these shares so I can get something back. The data says I first bought these shares on 2008-12-31. Obviously that is not correct, but it could have been when Epitan Inc became Clinuvel and when they did the stock transformation. I don't remember really. So did anybody else have this problem and how did you determine the cost basis of any stock you sold recently that were purchased so long ago?
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endymion96
Posted on: Apr 26 2020, 07:48 AM


Group: Member
Posts: 409

As far as I can tell, Clinuvel management is asleep at the wheel on this ... as more and more reports of skin problems show up related to COVID-19, management says ... nothing! Not a peep. Vaccines could take more than a year or longer (possibly never, still no vaccine for AIDS or Influenza) and they will not work year to year as the virus mutates. So, we need treatments!!!

New reports about skin problems below. You can bet if the main stream news media is finally reporting on it, then it is a huge problem. Report says 1 in 5 people are presenting with skin issues. That is 20% of 2.5 million people. I would call that a significant problem that could be addressed.

https://apple.news/AqS4JkcPWRCubzcspbIE_1Q
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endymion96
Posted on: Apr 25 2020, 02:33 PM


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Posts: 409

I think with the pricing so high, its bound to be ripped off and sold as a black market product. Remember the little blue pills? The price for the real thing used to be what $20 a pop. Black market was selling for $1 a pill? But you are right, they are gonna do it anyway, might as well see if partnering with a Chinese firm will potentially create an inventive on their side to stamp out the black market. However, when you do partner with a Chinese firm, what does that mean in terms of IP sharing? Is this strictly a distribution deal and no IP sharing? If not, then screw China. IP theft has to stop. There have to be consequences. People have to act morally and ethically.
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endymion96
Posted on: Apr 24 2020, 05:50 AM


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Posts: 409

The CCP should be shunned by all countries at this point. People should stop doing business with them.
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endymion96
Posted on: Apr 24 2020, 05:48 AM


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Posts: 409

Vaccine will be useless against a constantly mutating virus. There is the potential for these mutations to acquire gain of function and attack other cell types over time. But allowing the immune system to regulate the inflammatory response brought on by COVID-19, COVID-20, COVID-21, etc. via Afamelanotide is a better way to go in my estimate. I'm telling you that I am on to something here. I need others who have familiarity with what I am getting at to look into this.
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endymion96
Posted on: Apr 23 2020, 10:09 AM


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Posts: 409

PAD - Yes, I know what you mean, the immune system can produce pro-inflammatory and anti-inflammatory cytokines at the same time, but it is the melanocortin system that keeps them in balance and regulates metabolic homestasis.
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endymion96
Posted on: Apr 23 2020, 09:32 AM


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Posts: 409

"COVID-toes" ... you can take a look at the pictures. Scenesse has a part to play in the progression of this disease.

https://www.wusa9.com/article/news/health/c...S7YGGV8fgBGvJBc
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endymion96
Posted on: Apr 23 2020, 03:53 AM


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Posts: 409

There are many vaccines that and treatment cocktails that are being tested for COVID-19 that they use on HIV/AIDS patients. That is heavy duty stuff. Scenesse has a far better safety profile. We have this advantage which I think is most crucial. Additionally, it would be far better to let your own immune system battle the virus than to introduce drugs that may affect your body in other ways. Scenesse does not attack the virus directly, instead it super-charges your immune system to do it naturally and it fights the inflammatory response brought on by the virus so that your immune system can be effective.
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endymion96
Posted on: Apr 23 2020, 03:47 AM


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Posts: 409

I do not have any connections to the company and I do not live in Australia. I was hoping somebody nearby their office could knock on the door. I know IR is atrocious so its almost like why bother.
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endymion96
Posted on: Apr 23 2020, 03:41 AM


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Posts: 409

What do you know about it smart guy? Tell me one reason why you think it will not work in the way I said it would dumbass. I was experimenting with this 15 years ago. What were you doing with your thumbs?
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endymion96
Posted on: Apr 22 2020, 06:13 PM


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Posts: 409

Let me put this into focus for all of you because you did not seem to get the implications here ... Scenesse has a looooooong track record of safety. It is already approved in Europe and the USA. There are currently 150 drugs out there right now trying to solve the COVID-19 problem ... obviously being fast-tracked for clinical trials so that hopefully in 6 months they might have something. WE HAVE SOMETHING RIGHT NOW!!!! Ready to go. The winner of this vaccine/treatment race could stand to bag billions if not a trillion dollars. We know what we have ... all the studies out there for years and years. We know this drug's potential is galactic. All we need is a small trial at a hospital using it off-label. It does not take months to do this. Companies aren't even yet at phase 1 trying to get there.
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endymion96
Posted on: Apr 22 2020, 05:45 PM


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Posts: 409

Yes, I saw that too about a week ago and that led me to figure out Afamelanotide might be a possible solution. I listened to a person who was in Bejing in early November who said she came down with all these CCP virus symptoms including lesions on her hand and feet and that set off my alarm bells. She thought she had some type of foot and mouth disease, but it was COVID-19. Now this was early November so this whole story about a wet market and the first case coming out in December is hogwash. She said she went to a hospital and the first thing they did was take her temperature. It was high, so they said she had to go to the main hospital. Now why would a hospital deny you if you had a temp? Proves they knew they had an outbreak way earlier than the CCP admitted too. But anyway, like I posted a week ago, the patients coming out of Italy were seeing these skin problems too.
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endymion96
Posted on: Apr 22 2020, 05:42 PM


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Posts: 409

How can Afamelanotide stop COVID-19? By down-regulating NF-kB. You heard it here first. NF-kB is the master proinflammatory switch. This is what is causing a significant amount of the problems with this virus. I have several papers that I researched which led me to this conclusion, but I wanted to get this info out there now. PW and management need to get their butts in gear on this today. All my years of looking over what the melanocortin system is capable of and all of the data available on COVID-19, lead me to believe Scenesse is the key to stopping SARS-Cov and MERS-Cov viruses through this relationship. Somebody get this info in front of a company representative please.
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endymion96
Posted on: Apr 21 2020, 01:11 PM


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Posts: 409

I don't think people quite believe me when I tell you that Scenesse could be a very important drug in the fight against COVID-19. I have been doing more research on this. As I said before, MCR-1 is expressed on many cells in the body. COVID-19 mainly affects the cells of the lung, but new clinical data coming out of the patients in New York are detailing that kidney failure is also occurring and that there is an urgent need for more dialysis machines. The virus is also infecting T-cells and cells in the liver, heart, esophygus, testicles, etc ... As we know MCR-1 is also expressed throughout the body and acts as in anti-inflammatory that could prevent a lot of the inflammation occurring with COVID-19. This really should be looked into. Here is a good article that suggests MCR-1 activation is beneficial in suppressing ARDS and other issues, which is prevalent in COVID-19 cases.

https://www.frontiersin.org/articles/10.338...2019.00145/full
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endymion96
Posted on: Apr 14 2020, 07:01 AM


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Posts: 409

I believe you are correct, but I also believe the knowledge gained by this test would put this drug on the map as something more than just a cure for EPP. That is what I am getting at. Its true value and potential would the be known to the world while the world's eyes are looking for solutions. Any vaccine won't be ready for a year at least. If PW and crew get on this, they could have results by then. They must think out of the box vs. the GLACIAL pace they've been moving at so far. PW knows the potential, that is why he sees DNA repair as one of the brass rings. This was the other, go for it.
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endymion96
Posted on: Apr 13 2020, 02:48 PM


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Posts: 409

NK T-cells (and other beneficial immune system cells) express MCR-1, boom! Where the hell s PW? We've known this forever. Our drug is already approved and waiting to be used off-label in the US. At the very least, do the testing now to cement this drug as a game-changer around the world. If not because it helps people with all kinds of problems (which it does), at least do it for marketing sakes, d'uh!

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906236/
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endymion96
Posted on: Apr 13 2020, 02:33 PM


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Posts: 409

To be clear, I said "not directly". It will help in the sense that it will allow the immune system itself to fight back much more strongly and in that way it could be very useful, but we need testing on this now. If it boosts the immune system, that means it could boost Natural Killer (NK) T cells and white blood cells and other types of cells. Most people who catch this virus fight it off with their own immune system. Much of what the virus does to our body could be assisted by front line troops in the form of a boosted immune system. Inflammation of the lungs is a hallmark of the virus. We know Scenesse is anti-inflammatory. The release of free radicals and oxygen deprivation is also a hallmark of the virus. We know Scenesse has anti-oxcidant properties.
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endymion96
Posted on: Apr 11 2020, 07:09 PM


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Posts: 409

And what could possibly treat solar urticaria?

https://www.ncbi.nlm.nih.gov/pubmed/20969564
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endymion96
Posted on: Apr 11 2020, 07:08 PM


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Ok, so doctors are now seeing some CCP virus patients that are presenting signs of skin lesions, redness, hives, etc ... similar to urticaria disease.

https://bgr.com/2020/04/08/coronavirus-symp...ological-signs/
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endymion96
Posted on: Apr 11 2020, 06:48 PM


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double post.
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endymion96
Posted on: Apr 11 2020, 06:48 PM


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That's not necessarily true. Scenesse will due nothing against the virus directly. Its mode of attack will be defending what the virus does to the normal functioning of the immune system and in helping to repel the damage caused by the decrease in oxygen in the blood and by scavenging the free radicals set free due to the effects of the virus.
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endymion96
Posted on: Apr 11 2020, 06:28 PM


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Royco, from my research ... if Scenesse is of any benefit at all in fighting the CCP virus, it will be due to its anti-oxcidant properties in scavenging free radical iron particles and in combating inflammation in the lungs. I think it could help. Scenesse is already approved, has a decade long safety profile and could be prescribed off-label. No need to wait for a vaccine. Can somebody give this a go? Somewhere? Please? Its for science.
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endymion96
Posted on: Mar 23 2020, 01:38 AM


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China is lying about their situation. There is no F'n way a virus that spreads asymptomatically has burned through a population of 1.3 billion people in 4 months and their death counts aren't 10x, 20x, 30x higher at least. I have been watching their numbers of reported cases, deaths and serious or critical condition. They have flat-lined at around 80k after having grown in an exponential curve. That just doesn't happen. This is just not a natural progression. If you believe their Communist propaganda, then you are contributing to the oppression of the Chinese people. I hope people do not actually believe what their state-controlled media is pumping out to the world. The Chinese government is responsible for many deaths due to their opacity.
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endymion96
Posted on: Mar 23 2020, 01:18 AM


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Actually its ZINC that kills the virus. HydroxyChloroquine and Chloroquine Phosphate make it possible for the cell to pass the ZINC inside. Once inside, the ZINC interferes with the virus replication machinery through the blocking of an enzyme. So, if the virus cannot replicate, it dies. That is how it works. They are combining this treatment with azithromyicin. This is used to treat the lung damage. So you need all 3 components for a complete treatment.
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endymion96
Posted on: Feb 28 2020, 02:22 AM


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Saw that too, was not impressed. What the hell would hold them up that long. This is not rocket surgery. I'm not buying that it takes this long to push the drug out especially since its been in Europe 5 years already. I want answers.
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endymion96
Posted on: Feb 27 2020, 04:19 PM


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DNA Repair disappeared? WTH?
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endymion96
Posted on: Feb 20 2020, 04:13 PM


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Hope they are friggin' ready by Northern summer ... its only a few months away. Better be.
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endymion96
Posted on: Feb 17 2020, 06:54 AM


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No that is just first-time users experiencing side-effects. They tend to lessen with use. The reason is too much drug at once. I've said this for years ... these side-effects can be mitigated. If you really want to use Vyleesi correctly without much side-effects, you would first load up with small doses to get your body used to the drug, then use the full amount in auto-injectors. Doing it fresh, having never tried it, is bound to bring these kinds of reactions.
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endymion96
Posted on: Jan 24 2020, 05:07 PM


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I live near Washington DC. Its been a pretty mild winter so far. So I imagine farther south would be even warmer.
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endymion96
Posted on: Jan 6 2020, 07:14 AM


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I am heartbroken to hear the sad news about the fires raging in Australia.I have heard reports that up to half a billion animals have perished in the fire or succumbed to injuries. My deepest sympathies from across the ocean in America.
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endymion96
Posted on: Dec 16 2019, 08:14 AM


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How about this for the final slogan ... "One 'S' to rule them all, Scenesse". Call channel 7 news and put this last nail in the coffin of Skin Cancer.
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endymion96
Posted on: Dec 5 2019, 07:42 AM


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I saw something interesting on the google site that Uhohinc mentioned that he found over here. It was a comment, made by Lachlan Hay, related to either Juxtaposer or Madman before the AGM ... and that was that the Scennese "implant" darkens both light and dark areas of the skin in regard to Vitiligo sufferers. This makes total sense since the implant infers a systemic application of the drug. Lachlan also mentioned that it would be much better to apply a surface topical (i.e. CUV9900) to ONLY the light patched skin of Vitiligo sufferers to achieve the best result. So I have digested this information in regard to the competitor's drug. It too effects systemically as the drug is delivered orally. Therefore, they may not have a winning formula when it comes to the Vitiligo market. As we know, this pool is much larger than EPP. Additionally, Clinuvel is looking to apply CUV9900 to children and babies as it may be a better way to go safety-wise because who knows what effect Scennese would have on growing babies and children under 18 and their budding immune system? So that is very positive news.
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endymion96
Posted on: Dec 4 2019, 04:56 PM


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Posts: 409

There is truth to what LH is saying here. During the Clinuvel trials when they were noticing the side-effects of nausea, flushing, headaches, stretching, yawning, etc ... I knew from my experimenting that those side-effects were caused by releasing to high of a dose at one time. If, as I stated here years ago when I was yelling at the company on this board, they lowered the dosage and/or were able to somehow get a slow constant release, those side-effects would not have been as severe or would have disappeared altogether. As it happens, the more the drug is used, the less the side-effects occur. Of course the caveat here is that you are not over-dosing. The only side-effects that I found was the desire to stretch and yawn if the dosing was correct. That said, a pill form may be easier to control dosage. I sincerely hope that its efficacy is not so good so that my investment in Clinuvel remains safe. You guys are being unduly harsh on LH. He is presenting information that rings true with my experimentation, but I have to believe that this pill will not be so effective when all is said and done. My reasoning for this is due to the "lock and key" analogy. Scennese works extremely well because it mimics the natural key in a similar manner. I cannot see any key that isn't similarly formed having the same effectiveness.
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endymion96
Posted on: Dec 4 2019, 04:38 PM


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I can attest that the synthetic variant a-MSH linear peptide is a full agonist. Back in my experimentation days, I performed a crucial test after a few weeks of daily dosing. Normally, if I performed this test sans peptide, I would have become a deep red lobster as I do not tan hardly at all. My test involved heading out to the beach and laying on the sand between the hours of noon to 3pm in July on a sunny summer day. Mind you I did this test without applying any suntan lotion or protection of any kind. The result ... no sunburn at all. Later that evening, I had a developing tan ... which grew darker as the days went on. Now, obviously somebody might think that the tan was the goal. For me, it was not as amazing as the absence of a sunburn. That was the true magic and the reason why I am so frustrated that people like me must wait so damn long to use this drug commercially. I mean, what will it take, another 5 years for me to get my hands on it? The experience was truly life-changing. I can't imagine what EPP sufferers must think. Probably what I thought 10x!!! Now if this MT drug is only partially effective, it seems to me that it would not be my first choice. I have champagne tastes, so only the best, most effective treatment will do for me.
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endymion96
Posted on: Dec 3 2019, 03:06 PM


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If the newsletter was aimed at the retail investor, it was aimed at the unsophisticated retail investor. At the time of the AGM, I thought the info provided was great. DNA repair is the 3rd leg of the stool and upon successful demonstration, we will all have a nice, fat stool to sit on. What was lacking from the AGM presentation and the newsletter was not potential and vision, but concrete timelines for the vision to come to fruition. We have known about this plan for a few years now. The concentric circles diagram gave us the clue. I don't want to be negative, but this is the problem I see in the aftermath of the analysis of FDA approval ... the company is leaving everyone hanging. And as the SP sinks to pre-FDA approval levels, we're all getting paranoid. What would soothe my mind is an actual roadmap from the company.

Before FDA approval, I cut Clinuvel 18 years of slack. I allowed them to keep me behind a veiled curtain of secrecy and put all of my trust in management. Now that they have approval, all I am asking for is a little respect as an investor. If, for some reason, Clinuvel cannot reveal the roadmap just yet, then f-ing say so in the newsletter!!! Clinuvel, if you are reading this, the worst thing you can do to an investor is leave them hanging with their savings on the line (some of us anyway). I am quite sure that many of us might not be feeling this way if the threat of a competitor were not on the horizon. We will find out just how credible this threat may be in a few months ... and we will also find out how distant that threat is (not from Clinuvel but from MT timelines and roadmap). But in the meantime, where are the Clinuvel timelines/roadmap? Am I being too harsh on management or do you think we should know this by now? They have had years to review the phase IV data. They obviously know that DNA repair is already a reality, they just have to demonstrate it. I would think that this game plan was completed at least a year ago and the dominos have been set. If not, why? This is what I want to hear in our newsletter.

Ok, rant over. Serenity now!
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endymion96
Posted on: Dec 2 2019, 06:28 PM


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Go back and read the contents of that link all the way through. There were some interesting court cases where two biotech companies developed a drug for the same indication and the courts ruled both could be approved for use because one drug differed from the other by just one peptide or that one drug was administered once a week and the other daily and that this played a part in the determination that the two drugs were different and could each be approved for the same indication. Soooo, that 7-year exclusivity is not exactly a lock.
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endymion96
Posted on: Dec 1 2019, 05:16 AM


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Please stop the accusations ... its unbecoming. LH is who he has always been, albeit changing his perspective in light of new information. Is it overblown? That is what some of you think, but you are taking your accusations a bit too far. They best we all can do is wait a few months for the competitor's presentation of results and then re-evaluate. I appreciate both sides of the argument. However, this competitor is nothing to take lightly. Management has not yet addressed the topic so it is a normal feeling to be cautious and skeptical. Until we see hard facts and evidence one way or the other, there is no telling.
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endymion96
Posted on: Nov 27 2019, 04:32 PM


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The SP will grow on EPP sales now that we have expanded the market. Unfortunately, we will have to wait until Northern summer, 4-6 months at least. Groundhog day again. Money talks, bs walks. Show me the money! That is the driver for investors and that is the death knell for people shorting this stock. But until then, they will have their way. NASDAQ listing and a pump on DNA Repair and Skin Cancer prevention may also help. The funny thing is, this drug is the real deal. We should not need to pump it. When I found out that there are only 4200 investors in the company, I thought to myself, well that's a problem ... NOBODY knows about what this drug is capable of. This fault lies with management. Now that FDA has cleared the decks, its time to pump the shyte out of the future possibilities. Will they?
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endymion96
Posted on: Nov 27 2019, 07:59 AM


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Posts: 409

As far as competitors, Clinuvel has ...

1. First mover status (FDA approved)
2. MC1R stimulation through synthetic peptide variant of natural hormone (implies safe to use)
3. Maximum efficiency due to absorption through the bloodstream
4. Infrequent biodegradable injection (will be about as frequent as getting pill prescription refills)
5. Tons of phase 4 safety data and analysis

That's off the top of my head, if you can think of more please add. So the competitors may have a drug that triggers MC1R, but is it confined to area OUTSIDE the blood-brain barrier. If it is not, they may get more side-effects than they wanted and this may not pass FDA scrutiny. Secondly, pill form delivery may mean less effectiveness. Stomach acid will see to that. But if enough drug passes the stomach and gets to the bloodstream, it may work albeit slowly. We will have to see what effectiveness results from testing. Lastly, they do not have 5+ years of post- prescription, closely monitored, blood panels, liver tests, health data like Clinuvel has. I'm sure the FDA will not be as swayed about safety as they have been provided via Clinuvel's dossier. There is a chance that all this matters and will buy us more time than we think?
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endymion96
Posted on: Nov 20 2019, 02:36 PM


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After reading the AGM report, my take is ... the slow progress of approval was due to previous reluctance of regulators. Timing was everything and it is only now during the last decade that Scenesse would have had a chance at approval. And so it was, approved by the EMA 2014 and FDA 2019. This approval was due to much scientific research and data collected during the trials. Mounting evidence of safety and efficacy could no longer be denied by the regulators and their changing attitudes finally tipped the scales. Because of EMA/FDA approvals, the medical community, covering much of the western world, now acknowledges that the claims of systemic repigmentation and system photoprotection are indeed TRUE and accurrate. Clinuvel now wishes to prove that the third leg of the triangle, systemic DNA repair is also TRUE of this drug. Therefore, it intends to pursue small human trials as soon as possible. Once this is accomplished and the data is analyzed and the expected result is shown to exist, approval (by the regulators) of this final claim will conclude the goal set out by Clinuvel. It will be at this point that they will be able to market Scenesse and its follow-on products as a Skin Cancer preventative.

Apparently, any competition is years away from stealing any sort of market share. What surprises me is the total number of shareholders in Clinuvel, only 4,200. Wow! We are no where near the kind of viral growth I would expect from a biotech holding this kind of life-changing technology and opportunity for the future. I have to conclude that shares are very, very cheap even now. I applaud the vision spelled out in this report. This is the type of information I need to see from the company.
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endymion96
Posted on: Nov 19 2019, 05:02 AM


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If my maths are correct, that is equal to $41.44M US or $60.81M AUS.
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endymion96
Posted on: Nov 18 2019, 04:19 AM


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Maybe the company should appeal then. Their "false" advertising has been proven mostly true. The action of MT-II does indeed tan the skin and improve libido by way of stimulation of the Melanocortin system. These pathways have been approved by the FDA essentially. As for muscle building and improved fitness, the stimulation of the immune system apparently decreases recovery time between gym sessions or so anecdotal evidence from hard-core body builders would seem to suggest. Beg to differ Johnny H, but the manufacture of a small peptide chain such as Scenesse is fairly straightforward. This is not a complex drug compound. The fragility of it comes from breakage if handled improperly or violently mixed with bacteriostatic water. The only result would be less potency. The only danger that one may encounter would be taking a dosage in too large an amount which may result in anaphylactic shock. However, that would be on the user, not the drug. The real danger of blackmarket drugs is knowing whether you are getting an authentic product and not some cheap imitation in which the underground manufacturers may have cut corners to save money. A prime example of this behavior can be seen with groups producing THC vape flavors which have been contaminated and found to cause lung damage in the US.

I believe THIS is the main fear most people have in the blackmarket and the chief reason why approved drugs bought through official channels will always be preferred. The trick for Clinuvel (speaking from a financial point of view only) is to expand the market as much as possible. This will be done by adding medical conditions to the list of effective treatments. The FDA approved Scenesse without conditions. So WHY did Clinuvel offer pharmacovigilance to EPP patients in the US for a minimum of 8 years; essentially placing a roadblock on practitioners who want to prescribe off-label? Can this roadblock be overcome? Interesting question that I do not have an answer for. Will this extraordinary patient monitoring pave the way for wider acceptance and expanded medical need? Is this part of the looooong-game for Clinuvel? Is PW calculating a brilliant strategy that will "pay off in the end"? Or will this loooong drawn-out process only allow for competitors such as Mitsubishi time to catch up and steal the market away from us?
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endymion96
Posted on: Nov 12 2019, 09:51 AM


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No patent issues since it is not a peptide and has a different form of delivery to boot.
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endymion96
Posted on: Nov 12 2019, 06:18 AM


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This will become a major threat ... it all depends on the degree of efficacy. If it works, but not that well ... then we can all breathe a sigh of relief. If it works just as well as Scenesse, then its simply a matter of time until their drug is approved. We all must pay attention to the results which will be released in early 2020 at the scientific congress whatever that is. It will be impactful to our investment.
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endymion96
Posted on: Nov 11 2019, 06:45 AM


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I honestly don't know where I stand. I think my main source of frustration regarding compensation is that one person can absorb so much wealth while loyalty of long term shareholders gets nothing above and beyond what somebody who just bought in a year or three ago is getting. That is upsetting to me. We've been here as long as most in management if not longer. Yeah the SP is higher than its ever been, but 15-20 year holders get what bonus? Nothing. And I have been an ADR holder to boot, no voting rights. Maybe if we got some compensation for our loyalty that would make me not so hot to agree to the deal. Anyway, my voice is muted so this is all just venting. We should be so lucky with our short interest. the vultures over at Palatin average 60% short interest since approval. They've pecked it down to 0.80c US. So far no reverse split, but we shall see. Sales of the product will be coming in next quarter and I expect this to rocket. But with 227mln shares, their future is not going to be as bright at CUV with just 50mln. So, I look at both stocks and say, its not so bad over here.
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endymion96
Posted on: Nov 3 2019, 09:11 AM


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Posts: 409

A lot of people have been holding on to this stock for many, many years. I'm not sure where to get the info, but can somebody do a comparison of shareholders to see how many people finally cashed out and are finished with Clinuvel. I bet there were many people who figured they made a nice profit and they dropped off. I suggested that this might be the case over a year ago. So we had pressure coming from this pent up demand to sell and we had shorters jumping on a SP rising catalyst to bring it back down. The good news is that the next rising catalyst may not bring with it such a drastic decline if we've shaken out the shareholders who aren't riding this out to the end ... and by end I mean the next 4 years. But I'd be interested in the comparison of shareholders then vs. now. Another question, did FDA approval bring in new shareholders?
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endymion96
Posted on: Oct 31 2019, 03:55 PM


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Hey PAD, this one is for you!
https://www.yahoo.com/lifestyle/suzanne-som...-221844130.html
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endymion96
Posted on: Oct 28 2019, 07:45 AM


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Posts: 409

Right now the shorting action on Clinuvel is coming from CUV shares because there is not enough liquidity in CUVLY or LF to make quick trades (ie, get in, get out) intraday. Swing trading is a different beast though. That may be going on, but you have to time it right. With all the expected catalysts to drive the SP higher, I would not take a chance on this stock. Of course others might ... and that is why most traders can't hack it in the long run. They lose! That is why the fundamentals of a company are your friend over the long run. I do not care about the daily fluctuations because I know where we are headed.
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endymion96
Posted on: Oct 28 2019, 07:23 AM


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Posts: 409

They do because they can only afford to lose so much of their portfolio in one day. If they took out a big position in a high-dollar stock and lost it, they would get wiped out in no time. Day traders don't always win. Show me a day trader that wins consistently and I'll show you that they are a very rare breed. Only 10% of day traders are successful over time. Most flame out because they make dumb moves and then try to double-down and win back their losses. Trust me, they stay away from high-dollar stocks because these are dominated by the big boys with HFT algoritms who can afford to throw around big money and take big positions. Day traders stick to medium-cap companies with SP's having high volatility to make their money. The minimum requirement in the US to be considered a day trader by the IRS in US$25,000 (and this balance must be maintained through the year), make at least 4 trades a day, and spend at least 20 hours a week trading. Most good day traders say you need double that, US$50,000 to make a go of it.
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endymion96
Posted on: Oct 27 2019, 09:28 AM


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Posts: 409

One thing to keep in mind is ... the higher the SP, the less shorters will be attracted to the stock. The less volatility there is with the SP, the more institutional buyers will be attracted to get involved. The big boys play in the big pools and can afford the risk of paying for high-dollar stocks. I'm assuming that is why the SP of companies do not split until they reach a certain level where even in the split, the resulting SP will not invite too much trouble from shorts.
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endymion96
Posted on: Oct 25 2019, 06:52 AM


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Posts: 409

PTN recent fall from grace (above US$1.50) occurred due to 40 million share ATM offering just a day or so after FDA approval. This dumb move by management killed all of the momentum and then shorters came in and drove it down further. SP is holding at resistance level now waiting for Vyleesi sales news to pull it back up and onward. I believe, due to the way AMAG (licensee) is marketing the drug and the education of doctors that must first occur, ramp up will start out slow and then accelerate ...as will sales. So, SP will follow suit. I do not expect this investment to blossom until at least a year of increasing sales has been achieved. But I do believe once the train starts chugging along, it won't be stopped. At any rate, I'm not sure an apples to apples comparison to Clinuvel can be made due to the ATM used to fund PTN future pipeline. Both companies have an FDA approved drug, and both drugs work effectively. I believe the investment in Clinuvel is the better bet right now because Palatin has an effectiveness issue that it must first dispell. Similar to how many people thought Scenesse was not very effective due to incorrect measurement of sunlight exposure during trials, Palatin has the same kind of thing with going on with HSDD measurement effectiveness. The drug works and works well. If they can expand drug to male population, it will explode since males respond much more easily and the measurement (i.e. boner) is not in doubt ... where other drugs like Viagra, etc ... failed to work on some men. Sales of Vyleesi have barely even started. I don't expect any news until early 2020.
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endymion96
Posted on: Oct 24 2019, 02:52 PM


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Posts: 409

Unfortunately, this company's SP will never be truly safe from shorting until we have big institutional buy-in and millions more shareholders. There is a threshold where day trader interest declines and that only happens when volatility smooths out. When the hedge funds and instos invest, we will see these shenanigans end. But a NASDAQ listing is necessary step before that happens.
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endymion96
Posted on: Oct 24 2019, 10:10 AM


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Posts: 409

Story of my investment life as well. Never have the money to spare to load the account beforehand.
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endymion96
Posted on: Oct 22 2019, 01:15 PM


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Posts: 409

I think shorters played a part in the stock price movement, but I also have stated in the past what would happen upon approval. Perhaps a year ago, I predicted that the SP would spike, but it would then pull back by 25% BECAUSE so many of us have been invested in this company for so long that people were bound to exit at this moment. And true to form, some have admitted that they finally sold out or took a solid chunk off the board. This was all to be expected. The fact that we sit at a higher plateau now and that the SP fall seems to have subsided is good. For those who can afford the patience to see this thing played out, count me in your numbers. For those who chose to exit or take some profits, man I wish I had as many shares as you guys and gals. Hopefully, my ride or die strategy will eventually get me a ticket into the big leagues someday. Unfortunately, I am one of those who will have to endure more "time" to reach my goals. I wish I could quit my day job and go into semi-retirement, but that is not my path. My hope is we will all make it to see that grand party on Bondi Beach someday ... and that this drug treats numerous more diseases and people than we ever could have imagined. I will know my goal will have been reached when I can go to my doctor and get that first script. Until then, cheers to all for each hopeful, informative, venting, chiding, blue sky post. I am with you! Billy Boots especially.
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endymion96
Posted on: Oct 9 2019, 03:07 PM


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Posts: 409

You know what? The US market has not yet had a crack at this due to the trading halt. So, several hours from now, we will see if the FDA news has travelled across the country and whose big pockets are ready to gobble up some CUVLY. Should be another blockbuster day. At the very least, most can be assured that SP is locked in at a nice level of support from here on out.
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endymion96
Posted on: Oct 9 2019, 10:22 AM


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Posts: 409

I wonder if there will be more institutional buy-in now to buoy the price at these higher values now that risk is off the table? Something to keep an eye on.
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endymion96
Posted on: Oct 9 2019, 06:33 AM


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Posts: 409

Dumb investors who shorted this stock. Did they do any due diligence? Odds of approval were extremely high, especially with Vyleesi approval a few months earlier and only known deficiencies in dossier submittal easily correctable.
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endymion96
Posted on: Oct 9 2019, 06:04 AM


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Posts: 409

Their excuse is a health care system that rations care based on cost ... they tried to hide that fact by basing their decision based on supposed effectiveness when they knew the trials were flawed and patient feedback said otherwise. Now they are boxed into a corner I would think.
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endymion96
Posted on: Oct 9 2019, 05:08 AM


Group: Member
Posts: 409

Go to lunch, not expecting any news ... and look what happens!!! I've been an owner of this company since 2004 ... back when 2006 was supposed to be the celebration year that Epitan got this drug approved. I found out about the company because I was researching a way to protect myself from extreme sunburn. Of course, after doing the requisite research I learned that I'm just one of those people who cannot tan due to a genetic defect on my melanocyte receptors. This drug provided hope for me in that respect, but it will now provide treatments for others with worse conditions as well. As they say, I'm not only a buyer, I'm also (hopefully) a user of this wonder drug. Cheers to all of you who have weathered this storm together with me. Its been such a long road ... we can finally take a little break and rest a little easier.
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endymion96
Posted on: Oct 7 2019, 01:27 PM


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Posts: 409

I just want a nice pool in my backyard. On Night's Watch tonight ... listening to early David Bowie circa 1973. Shorts will scatter come morning time. I'd be surprised if this was not the case. Nothing else to offer but champagne wishes and caviar dreams! And finally, some relief to all sufferers whom this drug shall soon treat.
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endymion96
Posted on: Oct 5 2019, 01:56 AM


Group: Member
Posts: 409

I plan to drink heavily this wknd.
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endymion96
Posted on: Sep 30 2019, 11:16 AM


Group: Member
Posts: 409

Your modest parcel is more than I own. I wish I had more money to invest back then. As it was, I was taking out loans on my credit card to get what I now have. Its been a long road, I'm not selling until we hit $80.
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endymion96
Posted on: Sep 26 2019, 02:56 AM


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Posts: 409

So do we think the shorts are going to hold through the FDA approval decision or will they break a day or two before? If they hold, are we to believe that their modeling says to them that the probability of a negative outcome is greater than the probability for approval? I mean, lol. What evidence do they have for that? If none, then short action should break very shortly unless they have no clue about the sh*t storm coming their way. I cannot fathom shorting to this degree at this moment in time with this company. Can somebody explain their logic?
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endymion96
Posted on: Sep 16 2019, 12:37 PM


Group: Member
Posts: 409

New dealer coming in, place your bets. Will the shorts get burned on early approval? Will the FDA fast-track this puppy on its last hand-off to the anchor runner? Or will history repeat and maintain status quo?
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endymion96
Posted on: Sep 5 2019, 01:23 PM


Group: Member
Posts: 409

Tick, tock, tick, tock, tick, tock ... well we got through August. Now for the agonizing grind towards the finish line ... brutal. Several bottles of Syrah and/or Jamison at the ready.
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endymion96
Posted on: Aug 17 2019, 10:21 AM


Group: Member
Posts: 409

I agree with that conclusion. This study bolsters the case even more that Scenesse will be approved. Firstly, because efficacy is not in doubt, secondly because EMA already approved it, and thirdly, because the FDA has had 4 years of additional data to review.

Tom Petty once wrote a song ...

The waiting is the hardest part
Every day you see one more card
You take it on faith, you take it to the heart
The waiting is the hardest part
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endymion96
Posted on: Aug 8 2019, 12:17 PM


Group: Member
Posts: 409

Also ... I forgot, company insiders bought more stock.
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endymion96
Posted on: Aug 8 2019, 11:48 AM


Group: Member
Posts: 409

PTN surged 20% ahead of the AMAG Q2 financial earnings results. AMAG is the company that bought the rights to market Vyleesi in North America. When the transcripts were released the next day and the results weren't so good, the SP dropped back down. Not sure why there was such huge optimism for Q2, its Q3 that counts because that is when Vyleesi sales start ... in September.
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endymion96
Posted on: Jul 24 2019, 10:45 AM


Group: Member
Posts: 409

I think the main area of concern was due to synthetic aMSH contributing to skin cancer ... at least that was the fear originally. I mean, its in the name "Melanocyte Stimulating Hormone". As years of research and real-world data piled up, this fear has been demonstrated to be unfounded. This is why I believe the FDA has absolutely no problems with the safety profile and will not restrict usage. Off-label prescription is a possibility.
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endymion96
Posted on: Jul 22 2019, 01:48 PM


Group: Member
Posts: 409

And eventually skin-cancer prevention! It is a mind-job on when to sell isn't it? Basically FOMO should keep the SP at great heights. The shorters of this company just don't have a clue about its potential and for that, they will get burned.
  Forum: By Share Code

endymion96
Posted on: Jul 22 2019, 01:21 AM


Group: Member
Posts: 409

Of the 48mil shares, do you know the percentage owned by Australians vs. US vs. Europeans vs. Asia vs. rest of world?
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endymion96
Posted on: Jul 21 2019, 06:38 AM


Group: Member
Posts: 409

True, but we could have said that every summer for 5 years now.
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endymion96
Posted on: Jul 20 2019, 10:43 AM


Group: Member
Posts: 409

This delay until October may be a blessing in disguise. If the FDA had approved Scenesse in early July, it would have been a terrible time to make in introduction to the US market. Summer is typically a very slow time when people are off on vacations and holidays. However, it is a great time to buy stocks on the cheap. On the other hand, the planned early October approval date will provide MAXIMUM momentum to the share price as investors will be in full motion looking for good deals. Its like timing when a big blockbuster movie will come out ... this is ours!
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endymion96
Posted on: Jul 18 2019, 03:46 PM


Group: Member
Posts: 409

I'm not selling one share. I've always been ride or die with this company. I learned my lesson that when you try to time the waves for a few pennies, you end up missing the big one that takes you all the way home.
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endymion96
Posted on: Jul 18 2019, 01:42 AM


Group: Member
Posts: 409

New article on SeekingAlpha about Clinuvel. Article is negative about future prospects, but I don't believe it is well researched and taking into account all aspects. I can't figure out how to get the URL, but the title is "Clinuvel: Bubbling And Ready To Burst". Author believes current SP is a bubble and company is not worth investing in at this point. I have too much to say about that, but have to get to work right now.
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endymion96
Posted on: Jul 15 2019, 08:55 AM


Group: Member
Posts: 409

Bookmarked!
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endymion96
Posted on: Jul 11 2019, 01:37 PM


Group: Member
Posts: 409

I'm fairly certain you are on target here. I doubt the FDA has plans to monitor after approval. This is probably why they need to be very cautious with the labeling and manufacturing and hence the delay. The one thing I found curious is that when speaking about the knowledge transfer between the EMA and FDA, the word "presume" was used. I'm surprised something more concrete was not applied. I guess Clinuvel is not privy to those communications; however, I am encouraged by the rest of the newsletter. These are the kinds of newsletters I like to see. Its taken years to be as forthcoming as it should have been all along, but I'll take it late than never. Everything appears to be going to plan and the future is looking fantastic.
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endymion96
Posted on: Jul 10 2019, 01:27 PM


Group: Member
Posts: 409

The reason I have been bringing up Palatin in relation to Clinuvel is for several reasons. Firstly, they are not a one drug company. Palatin has several drugs in the pipeline that work through the MC1-R receptor. This means they might possibly be a competitor even though their drugs are targeting specific diseases and medical conditions for which Clinuvel is not. Their business model is centered around the cyclic form of a-MSH whereas Clinuvel's is the linear form. In the US, off-label prescription is not uncommon. Another reason for comparison is management styles. Their management is much more forthcoming with information, but also has made some mistakes. People can learn from these mistakes and hopefully recognize certain moves by mgmt which may help them with their investments here. Also, we can also gauge the public's appetite for a new class of drug of which Vyleesi is the first melanocortin over the finish line. I don't think safety was an issue at all with PT-141. What is was ... was, as I have been shouting from the rooftops for years, a problem of dosing. PT-141 was rejected by the FDA because Palatin originally administered their drug nasally. From my research and experimentation, this meant too much drug too fast and bam, problems!!! So what they did was go back to the drawing board and repackage the same drug, but administer it sub-Q which is a slower process. It still has problems of being a bit much for some, but you can't go sticking yourself several times over the course of several hours to get the effect you are looking for as that would be impractical. So it all comes in one dose. This is why some minority of people will get nauseous or develop a heat flash with Vyleesi. Clinuvel has the lock on the slow-release administration method which makes it much more tolerable, but both drugs are safe and very specific and thus have an advantage over other drugs which are trying to accomplish similar outcomes. For instance, Palatin has a drug in the pipeline that will compete with Humira, Ozurdex, steroids, and others, but is much safer having much less contraindications. Treating diseases with peptides is a relatively new area of research. So it makes sense to follow related companies especially since Palatin and Clinuvel will be competing in the DNA repair and anti-inflammatory areas. What I am not sure of is how much overlap there is between the two companies and where the line is regarding infringement on patents. For instance, Palatin has developed an MC1-R drug that can be taken orally for inflammatory bowel disease. They have demonstrated that their peptide makes it past the stomach and into the intestines where it has direct action on the receptors. Could Clinuvel potentially do the same? Why is Vyleesi administered sub-Q and not slow-release? Are their patent infringements which prevent one from the other? So that is some of the reasons why I highlight this company. Could the two companies perhaps merge in the future? Many questions. Also, I think literally nothing will happen between now and the FDA decision on Scenesse in October, so I think some new lines of discussion can cure some of the boredom while we wait.
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endymion96
Posted on: Jul 9 2019, 07:40 AM


Group: Member
Posts: 409

Fun fact: I chose the bananna as my avatar years ago for one reason only. Who wants to know why? Its because Clinuvel kept slipping their schedules on us. <snare hit, cymbal crash> and laughter ensues ...
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endymion96
Posted on: Jul 9 2019, 02:07 AM


Group: Member
Posts: 409

If you need a new high while you wait, you can always join the fun over at Palatin. FDA approved drug over here, though management gaffed and issued 40 mil new shares a day after approval. Shorters had a field day (and still are). I got in super cheap as anyone can now at $1. But let me tell all you Cinuvel longs something, I really appreciate how stubborn and patient you all have been. For myself, I have been in this stock for 15+ years. I only recently took up a stake in PTN. However, the contrast in stockholders is striking. I amuse myself by reading the posts on the stocktwits board. The patience many of these posters display is that of an amnesiac who has ADD. They are bitching about the stock not going up within several months of buying in, much less a year. The "longs" over there maybe have been in for 2-3 years. We strong hands of CUV and CLVLY spit at that and fart in their general direction. The many weak hands of PTN say they will get out with 0.20 cents profit when the SP goes back up and they will wash their hands. This is why the SP is hovering at the dollar mark right now. Hahahaha ... I mean really? The sales of Vyleesi don't start until September and they can't even wait 2-3 months. I think Clinuvel management should give all of us medals, we're practically saints of patience.
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endymion96
Posted on: Jul 8 2019, 02:59 AM


Group: Member
Posts: 409

Did you see the other lecture mentioned, "The role of DNA damage repair and transcriptive stress in aging and the impact of nutrition"? If DNA damage repair slows down aging, eating fruits and veggies ain't got nothing on Scenesse!
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endymion96
Posted on: Jul 5 2019, 01:58 PM


Group: Member
Posts: 409

FWIW, Vyleesi did not require an advisory committee either. Stated reason by FDA was no safety concerns or efficacy issues requiring outside expertise. You can read about it in their approval letter and commentary in this news article.

https://www.buzzfeednews.com/article/danver...-women-approved
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endymion96
Posted on: Jul 1 2019, 03:11 PM


Group: Member
Posts: 409

Imagine taking a spoonful of Scenesse or popping a tablet? It might happen in the future. Check out this article describing the breakthrough discovery.

https://www.sciencedaily.com/releases/2018/...80221122406.htm
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endymion96
Posted on: Jun 27 2019, 11:33 AM


Group: Member
Posts: 409

As we bide our time over here, I checked in on the strangeness over in PTN land. So the first melanocortin drug gains the all-powerful and nearly unattainable FDA approval and the SP goes down? Why, I wondered? So I started reading over on the stocktwits board. Apparently, the company issued 40 mil new shares right after approval and then promptly the company execs and insiders bought cheaply on the dip erasing shareholders expected profits, but securing the company's financing for the future pipeline development of 4 new drugs in development. So the result, 100 mil in the bank to fund the pipeline, insiders are fat and happy, institutions are able to buy in cheap now derisked, and weak hands and some long-time shareholders are selling their shares in frustration. But, the future for that company looks very bright. Moral of the story? You have to be wise to the ways of the masters at the top of the pyramid. If you don't know the games and how they are played, you might just sell all your shares in a fit of rage and lose out on the huge profits the wizards of wallstreet leave for the rest of us. The best play for the peons that got in recently (circa 1-2 months ago) would be to average down on shares right now, not sell out. Its fun to watch the game when you are not too invested. Since I got in (hopefully at bottom), I am going to enjoy the ride up. Still, patience is required. As we all know, "in the end, it will pay off"!
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endymion96
Posted on: Jun 25 2019, 09:49 AM


Group: Member
Posts: 409

Sloppy research too or ... might be paid to "omit" a potential treatment/cure by a competitor aka Clinuvel.
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endymion96
Posted on: Jun 25 2019, 06:12 AM


Group: Member
Posts: 409

Yes, I could see that point of view, but it sounded like he didn't know. If he knew, it would have been brilliant insight for him to explain it. While this drawback is a valid point of contention, the delivery mechanism can be overcome. Palatin has an approved melanocorin drug on the market, that is what counts as far as the pure investment is concerned. Sales will come eventually, especially with other medical conditions they are looking to treat or cure. Clinuvel has and is the same prop bet except it effects a different MCR.
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endymion96
Posted on: Jun 25 2019, 04:03 AM


Group: Member
Posts: 409

If he does not know why the drug is an injectable vs. a pill, he hasn't done his research and nobody should be taking his stock advice. OMG, this guy.
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endymion96
Posted on: Jun 25 2019, 01:57 AM


Group: Member
Posts: 409

In the absence of negative news on Vyleesi, I have to attribute this to profit-taking by long suffering shareholders. I bought more on the dip. Approval of Vyleesi is great news for Clinuvel and its melanocortin drug. I can't believe the shorters dared to short CUV so harshly last Friday. I have to think they believed Vyleesi would fail to meet approval and thus affect Clinuvel's stock price negatively? Since that did not happen, they should be afraid of the short-squeeze at this point.
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endymion96
Posted on: Jun 23 2019, 04:48 AM


Group: Member
Posts: 409

You are a risk-taker after my own heart PAD! Congrats on having the stones to go all-in. Let me know what date you will set for the yacht party next summer. As for a dude version of Vyleesi, why do they need a dude version? Wouldn't it be the same thing? Is it just marketing? I don't know how stimulation of MC4 affects females, but I do know from first-hand experience that MT-2 worked like gangbusters for me, bloodflow increase and the effect, "strong like bull". I tried viagra once just to see what it would do ... it gave me a heat flush so bad, I stopped using it. That's why I bought some shares of PTN as well. Some people are looking at the treatment of HSDD and the projected sales to come as minor. Who knows? The other drug on the market had poor sales so if that is all it was good for, they might be right about their cautiousness. However, back in my experimentation days, I already knew of Vyleesi's potential to rival viagra and actually overcome the side effect that I experienced. The nausea thing is due to injecting too high a dose all at once. I have been saying for years that this side effect was easy to overcome by taking lesser dose more frequently, but I guess that would be impractical if your only method was Sub-Q. That is why Clinuvel has an advantage. They locked up the slow-release administration method and topicals with their patents. Although I'm not sure if that would apply to other melanocortin drugs or just those that affect MCR-1? Anybody know?
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endymion96
Posted on: Jun 19 2019, 02:10 PM


Group: Member
Posts: 409

CLVLY volume today at 30.34k is about 10x normal. This rocket has achieved lift-off, USA has taken notice.
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endymion96
Posted on: Jun 10 2019, 07:36 AM


Group: Member
Posts: 409

I actually like the "Frilly" text on the front with the graphic. I would move the more lengthy wording to the back of the Tee. Why? Well, people would see Friily w/graphic and ask, what's that all about? Then you turn around and show them the Clinuvel, the stock tickers, Scenesse, the amino-acid formulation, and a brief text of what it is/does ... world's first photo-protective synthetic hormone? Something like that, listing all the great qualities, anti-inflammatory, etc ...
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endymion96
Posted on: Jun 6 2019, 04:10 PM


Group: Member
Posts: 409

For me its not greed. Its being paid for not blowing my brains out after 15 years of waiting. Its also because I think this is a wonder drug that will help millions, not just EPP population. Its untapped potential. Three months is ok I guess, just wait a little longer and keep the pot boiling in anticipation. Hey, one of you high rollers wanna throw a yacht party when this is done? Unfortunately, I did not invest enough for a yacht, but Ill gladly come aboard and throw a few bottles of Champs around.
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endymion96
Posted on: Jun 5 2019, 06:04 AM


Group: Member
Posts: 409

As RabbitRun concluded, it will be illuminating to keep our eyes on PTN and see what happens there. If, for some reason, there is no delay and their drug gets approval, that may mean it was only CMC issues with Clinuvel and signs would indicate approval is almost guaranteed and will be forthcoming in October. If PTN is also delayed, then we could assume the FDA really is slammed and understaffed or behind. If PTN is not delayed, but rejected that should not be to worrisome for CUV because Scennesse does not pass the BBB and has excellent safety ... we would just have to wait for the decision in October (that would be the worst case scenario). To me, what the FDA does with PTN (in just a few short weeks) will speak volumes about the chances of Clinuvel. I would not be selling right now hoping to buy back cheaper because PTN could slap the writing on the wall as to what to expect with CUV. Anybody who gets out now may get caught with their pants down if PTN is approved. Plus the ASX200 listing, plus a NASDAQ listing all before October. I'm on pins and needles with what is just around the corner ... the PTN decision is targeted for 23 JUN 2019. Hold onto your hats!!!
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endymion96
Posted on: Jun 4 2019, 05:17 AM


Group: Member
Posts: 409

I tend to think the delay is good news for the SP. In my mind, the ASX200 inclusion was set too closely to the FDA "assumed" approval date. Now that it will be spread out, this will allow a further opportunity for the CINUVEL story to spread and the SP to rise beyond where I think it would have landed. If we can couple this delay with a NASDAQ listing, even better ... actually much, much better. If the company can get their story out to American investors through a NASDAQ listing, you will see alot more people buying the ADR CLYLY on the run up to a listing, so I would keep an eye on volume there.

As for Dr. Wally's notion that all the big Sun Screen companies are dreading the approval of Scennesse, I wonder if there isn't some truth to that and I wonder if it is somehow impacting the FDA decision to delay. Makes you go, hmmmmm???
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endymion96
Posted on: May 29 2019, 12:50 PM


Group: Member
Posts: 409

All that shorting pressure and they still can't contain the rise? I'm sure people noticed the CLVLY volume. Its 7x times normal. This next month will be a very interesting time.
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endymion96
Posted on: May 13 2019, 04:19 PM


Group: Member
Posts: 409

Is this a Game of Thrones reference? I like it ... "Approval is coming"!!!
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endymion96
Posted on: May 4 2019, 01:47 PM


Group: Member
Posts: 409

I think most of the commentary is directed toward getting the manufacturing procedures nailed down and could be chalked up to software configuration issues. Either the procedures weren't captured properly or the software didn't have all the capabilities that the reviewers were looking for at the time. However, looking over the white paper, it seems the openLab software can address most of the problems discovered in the report. For example, the user roles and permissions problem ... on p. 10 of the white paper, it talks about a "Users" module which should take care of the problem. "The Users module enables simplified user management including definitions of roles and permissions". So it appears that the documentation provided by Clinuvel did not address setting up roles and permissions and needed to be updated because clearly the software can handle this type of thing. I believe audit trails could also be handled via the reports module and it looks like you could login remotely and securely view the data/logs as well from other stuff I was reading. The second link (software admininstration) talks about Instrument management/status and also activity logs on p.44. I think its basically just a matter of learning the software and documenting the procedures that they've missed.

http://hpst.cz/sites/default/files/attachm...-9120en-eln.pdf

http://www.ingenieria-analitica.com/downlo...inistrators.pdf
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endymion96
Posted on: Apr 30 2019, 02:03 PM


Group: Member
Posts: 409

I live about an hour from the FDA. Do you think Dr. Woodcock would let slip any info if I casually ran into her in the cafeteria by accident? lol. I think chances of an early decision are good considering that NH summer is only one month away. Why waste time when people are suffering? Shorts will rue the day, but thanks for letting me top off.
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endymion96
Posted on: Apr 27 2019, 04:45 AM


Group: Member
Posts: 409

Anybody wanna take a guess why there is so much shorting on Clinuvel stock over the last several weeks? Do you think these people have no clue about the potential of Clinuvel and the impending FDA decision and just smell blood in the water? Day-traders? At some point in the coming weeks, the shorts will let up because they will inevitably lose. I wonder if they are aware of this? The FDA approval will be the launch point for all the other goals that Clinuvel execs want to accomplish. This one event will be the cataylst for all that is to come.
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endymion96
Posted on: Apr 27 2019, 01:53 AM


Group: Member
Posts: 409

I'd like to thank the shorters for allowing me one last grab for the ring. P.S. I almost said "punch at the clown" but thought better of it. At any rate, thanks!
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endymion96
Posted on: Apr 23 2019, 04:00 PM


Group: Member
Posts: 409

PD, I'm thinking NICE will have egg on their faces if FDA approves and Clinuvel expands their list of positive benefits of the drug to include what we know it does (i.e. DNA repair, etc.) for other diseases. They will look a bit silly to have rejected such a novel and miraculous drug.
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endymion96
Posted on: Apr 23 2019, 03:54 PM


Group: Member
Posts: 409

Does anybody know if the FDA has required a registry for other drugs? What are the implications if they do not require one? Does that mean off-label usage is a foregone conclusion and perhaps a much wider market than we think will spring up?
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endymion96
Posted on: Apr 23 2019, 03:45 PM


Group: Member
Posts: 409

G dawg, there was nothing ever terrible about it and the drug was never dodgy at all. The simple fact is ... under the then formulation of the drug it just had too many side effects. It gave you a tan, it increased your libido, it suppressed your appetite, etc. It did all this because the structure of the amino-acid chain was small enough to pass through the blood-brain barrier (bbb). Therefore, it activated more than just the MC-1R pathway to include the MC-3R, MC-4R, and MC-5R if I remember correctly. This is why it had so many side-effects. The FDA said, "nah bro, ain't gonna pass like that". They also said sunburn prevention was not a medical condition worthy of approval ... and they definitely did not want to approve a "tanning" drug and attach their name to it. But in my opinion, what the hell was wrong with all those side-effects? I'd take every one of them, lol. Eventually, the chemists found a way to silo the side-effects by tweaking the structure of the drug. Epitan regrouped as Clinuvel and refactored the drug to a straight amino-acid chain which was different from the original and too large to pass through the bbb. Therfore, it only had the obvious tanning side-effect without the others because it mainly activated the MC-1R. Of course it still retains all the really great properties of DNA repair and free radical scavenging, etc ... because that's what happens when the MC-1R is triggered, lucky for us shareholders. Palatin, on the other hand, took their formulation in the other direction and concentrated on the libido enhancement aspects. However, because their drug passes the bbb, they have more complications and may have a harder time getting FDA approval for their drug. But we shall see ...
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endymion96
Posted on: Apr 8 2019, 04:03 PM


Group: Member
Posts: 409

I'm thinking 19.00 USD is fairly cheap for Clinuvel after looking at RYTM, no?
  Forum: By Share Code

endymion96
Posted on: Apr 6 2019, 12:12 PM


Group: Member
Posts: 409

Frilly til' I'm silly.
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endymion96
Posted on: Mar 28 2019, 01:46 PM


Group: Member
Posts: 409

Can I play devil's advocate with the SP predictions? The volume for CUVLY is anemic. I would think that if US investors were aware of the pending FDA approval, they would be bidding up the stock right now and volumes would be greater than 10k avg per day. So that is not happeneing ... yet? What makes people think that it will? I mean, I hope it will but I just don't know. We should want a NASDAQ listing first way ahead of approval to make the SP rise as we all agree it should (ie company is undervalued). What I'm saying is NASDAQ listing gives the company visibility. If the NASDAQ listing comes near approval, I'm not sure the SP will bump that much post-approval. Therefore, I think the SP will be bid up by investors in the Aussie market, not the US unfortunately. If that prediction is true, then the question is will US investors buy into a drug after the pop of approval is done? They may in the future, but it could be slow progress here as well.
  Forum: By Share Code

endymion96
Posted on: Feb 21 2019, 06:19 AM


Group: Member
Posts: 409

I believe it will continue onwards and upwards, but I did sell 2000 shares just to get my original investment back. All the rest is house money and I'm letting it all ride. However, there is a twinge of pain on what those 2000 shares might do in the future and what I might have lost out on. Its kinda like the guy who bought a pizza with 100 bitcoins back in the day, d'oh! This is what years of holding have done to me ... and years of watching the prior track record of the SP. I should have known better but played it conservative. I'll still make out very well in the end though.
  Forum: By Share Code

endymion96
Posted on: Feb 20 2019, 06:46 AM


Group: Member
Posts: 409

Does everybody think the SP is only going up from here? Does anybody think it will drop at all before the FDA decision?
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endymion96
Posted on: Oct 11 2018, 08:26 AM


Group: Member
Posts: 409

My guess is it is all based on high cost of the drug. Socialized medicine leads to rationing. I would bet that their cost to benefit analysis skewed the panel's decision. Using the unorthodox measure of effectiveness was simply a way to mask their true feelings and show them not as monsters for rejecting the drug, but instead as concerned and meticulous judges using the guise of effectiveness as cover.
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endymion96
Posted on: Sep 29 2018, 01:38 PM


Group: Member
Posts: 409

I might sell 1/3 to 1/2 my shares post-approval at the peak mania spike so I can buy a nice house and hang onto the other 2/3 or 1/2 for the duration while they explore new avenues in the next decade. Hitting the spike should be a fun game.
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endymion96
Posted on: Sep 27 2018, 12:40 PM


Group: Member
Posts: 409

I will make a statement based on my experience of being long this company since the Epitan days. The SP will hold its value because its base is made up of all the long-timers. The new kids are just now getting in. They will not be selling at any value less than what they purchased (most anyway). So the SP will hold here as the lowest base of support and will be shooting up. If mania takes hold, it may spike. My target for the tip of the spike is +40. It could drop from there 25% but will steadily climb even higher if Clinuvel follows through on their long-term goals. It will be interesting to see how the players in this forum play the game from here on out. Can't wait for that celebration party we'll be having someday. Good hunting!
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endymion96
Posted on: Aug 28 2018, 03:19 PM


Group: Member
Posts: 409

Not everybody in the US is on Medicaid. In fact, most people try to avoid it and find free market alternatives. With the lynch pin being pulled out from DemocratCare via last year's vote on the tax system overhaul (i.e. no more tax penalties for skipping it) most payments would probably be dependent on the insurance companies prerogatives.
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endymion96
Posted on: Jun 25 2018, 04:53 PM


Group: Member
Posts: 409

Wouldn't the opposite of Ignoramus be Intelligensus?
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endymion96
Posted on: May 13 2018, 04:09 PM


Group: Member
Posts: 409

15k cuvly
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endymion96
Posted on: May 6 2018, 10:25 AM


Group: Member
Posts: 409

Maybe I missed the memo, but what is the significance of the cosmetic line rollout? I thought this was a pharma company? Is the product non-drug related? What is it?
  Forum: By Share Code

endymion96
Posted on: Mar 17 2018, 04:14 PM


Group: Member
Posts: 409

Yes to all of that. Now if they could just rework that brand logo ...
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endymion96
Posted on: Feb 23 2018, 01:16 PM


Group: Member
Posts: 409

The new logo should be a defibrillator. Guys, it really sucks. I'd like to know what was wrong with Frilly? That was distinctive branding. Ok maybe you don't wanna associate a lizard with skin care, but maybe you take that frilly part of the lizard and put a capital C in place of the head? Keep it simple. With the head gone you no longer have the "reptile" per se, but you keep his cape to imply protection and the Aussie connection. Moon thing is rediculous. Drug offers protection from the sun, not moon. Throw some sun rays around the frilly necked capital C and you got a winner logo.
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endymion96
Posted on: Jan 30 2018, 05:44 AM


Group: Member
Posts: 409

I would say that Dr. Agersborg's appointment was meant to keep it all in the family. Confirms my assumption that PW wants to steer this company away from any takeovers and into the stratosphere as a future big time Australian pharma. The phrase "new territories" is key.
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endymion96
Posted on: Jan 21 2018, 01:47 PM


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Posts: 409

After all these years without a change in style or pattern, I think PW's non-communication with shareholders must be on purpose. So then the question is why? My guess is that he wants to fly the company under the radar to escape a potential takeover. He will not settle for peanuts. He wants to turn this company into a full-fledged Austalian pharma. And how is he going to do that? He is going to leverage synthetic-MSH into all sorts of areas as witnessed by the many studies we've seen. It may take another 5 years to get there, but the payoff is obvious. We will start seeing results in 2 years, maybe less depending when FDA approval is given.
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endymion96
Posted on: Dec 21 2017, 02:38 PM


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I wonder how much the rationing of healthcare and the ability to pay with limited funds comes into play in the NICE decision? I wonder if these regulators, without knowledge of the EPP sufferers and lifestyle choices, simple say, "hey they can cover up and shelter at home and they will be ok. We can't approve this, we've got bigger fish to fry"? It may actually work out that their negative outlook might actually work in favor of the drug and the FDA decision. The FDA might look at the safety data and the efficacy of the drug and say, "this one has a better track record than most of the stuff we approve, let's do it. Also, politically it would demonstrate our leadership by going against an obviously flawed reasoning by NICE. Let's give them a black eye on our announcement of approval." One can hope. If there is a political angle in these competing health organizations, I could see this play out.
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endymion96
Posted on: Dec 10 2017, 07:48 AM


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Unfortunately we have to wait at least another year or two before our patience and sanity will be relieved. The good news is ... the extremely long track record of safety of this drug is a cold, hard fact. Efficacy was never in doubt. Twelve or thirteen years ago, I knew of its efficacy through self-trials and wrote extensively about it on an old website some of you may know. Side- effects were known (i.e., headaches, sniffles, muscle weakness, etc ...) and those effects were the result of over-dosage. The key was slow-release. When a report from Clinuvel came out several years later listing these side-effects from trial participants, I was livid because it was known to me years before that you cannot administer all at once and that Clinuvel's slow-release product was not slow enough. I suspect and hope that this issue has been sorted out by now and perhaps is now incorporated as part of the final product. In the years following, we've all read about new research and the possibilities of this drug to not only treat light-related skin conditions and diseases, but far more. Clinuvel may ultimately have its hands on a life-altering drug that treats far more conditions and diseases than we can imagine ... noting that most of the discussions on this board, that I've seen, have to do with the small population on EPP sufferers and perhaps Vitiligo concerns, I suggest that it is only a matter of time that the mainstream wakes up to the possibilities of melanocortin stimulation. So with that, I offer this ... to bide your time as you wait for this glacier to melt ... I foresee this "other" research gaining traction and notoriety in the coming few years. What this means for us investors is a giant slow-building ramp of press coverage and interest in the company. By the time this thing actually pays off, it will have so much pressure built up that it may explode, nuclear style. With that I bid you adue for now.
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endymion96
Posted on: Nov 28 2017, 01:51 PM


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The funny thing is Clinuvel's mgmt is probably older than most of us. You'd think they would want to get the show on the road sooner so they might enjoy the fruits of their work? Maybe these regulators really do slow time down to a crawl? However, I did read that bit in the report about making sure the "Group" or senior staff were well paid in order to ensure the greatest level of effort and consistency, or whatever ... does it really take 15-20 years to cash in on an investment? Well, I'm still in my capsule on the way to Mars. Going back to hyper sleep.
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endymion96
Posted on: Sep 21 2017, 04:22 PM


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A little ZEST is good from time to time. Funniest thing I read all day! Lol
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endymion96
Posted on: Aug 8 2017, 10:13 AM


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Thanks! I appreciate the info.
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endymion96
Posted on: Aug 2 2017, 03:11 PM


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Hi all,

It's been awhile, remember I've been in hyper-sleep waiting for this drug and this company to land on Mars. I see we've still got a ways to go. Who can tell me when the major patents expire?
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endymion96
Posted on: Jan 17 2017, 03:48 AM


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My first post in a long while. Woke up from hibernation to Mars. Disappointed to see we're still a ways off. Anyway, enjoy the article!

https://www.lewrockwell.com/political-theatre/fda-rip/
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endymion96
Posted on: Sep 1 2016, 01:23 PM


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Slow-release is the ONLY method that would ever work. Back in my experimentation days, the slower and lower you went, the less side effects you had. In my opinion, even the delivery rate they have now is too fast. If they could slow it down even further and create a more constant dosage level while doing so, that would be "game over" or at least better for the end user in terms of lessening side effects to the point of zero.
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endymion96
Posted on: May 24 2016, 03:55 PM


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No, it's not that. It's because there are many sue-happy people looking for mega-bucks. FDA has to always make sure it's i's are dotted and t's crossed.
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endymion96
Posted on: Feb 28 2016, 06:22 PM


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HAL, have we landed on Mars yet? Ok, back to the chronos-chamber. Wake me when we're close please.
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endymion96
Posted on: Jun 5 2015, 12:25 PM


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I have been in hibernation. Anything happening? No? Ok, back to sleep. Its a long ride to Mars. HAL, please turn down the lights.
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endymion96
Posted on: Feb 15 2015, 04:09 AM


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The tanning thing will never happen. I've resigned myself to that. Would not even discuss that aspect unless and until a skin cream is researched and targeted for development. So for now, I will keep my feet in reality and try to steer the ship towards wider market applications. And yet, management has not given us much hope that there is any other possibity except for Vitiligo. Why? They have the research in front of them as easily as I can find it.

What I am looking for is a statement from them saying ... at the moment and in the near future we are developing the drug for the treatment and cure of Vitiligo; however, with current advances in science, we have evidence of future treatments for the following diseases and we expect to head toward that direction as soon as revenues dictate.
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endymion96
Posted on: Feb 9 2015, 04:28 AM


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Yes, of course ... these things will take time and money. But my point is ... get the word out that you have the patent rights and that you WILL be pursuing this direction in the near future once significant revenues allow. Has this been said? No. Why? Do they not have the patent rights? If they do, then why wouldn't you let it be know that you hold an approved drug with potential to change the world? This is easily backed up by research reports of the last 10 years. I can site several that I have been reading lately ... they just blow my mind with what they have proven ... in vitro. So this begs the question. Where is the PR machine? As others on this forum have demonstrated with articles about other drugs and pharma companies, one does not need an approved drug to strike home company value. But we have one now. Some variants of this drug are simply more selective as to its effects. Scenesse is approved; these variants I speak of are subsets. It should not be too hard to push these variants over the finish line as a cure and treatment for many other diseases that affect a much wider class of people. It could simply be that approval was so in jeopardy due to the regulators that all had to remain quiet. This is my hope and this is why I am still hanging on, but I have not bought any further shares. I don't know what you call that, pessimistic optimism?
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endymion96
Posted on: Feb 8 2015, 05:45 AM


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LRS, I appreciate your summary of milestones to be accomplished. I am still hanging in there, but at the same time, PW's statement about not pursuing the anti-inflammatory, anti-microbial, and anti-oxidant qualities of this drug that have been scientifically proven in the research reporting of many individuals and labs spanning many countries over a period of the last decade ... in favor of its photo-protective properties, which is merely a side effect of what the drug is actually doing, seems misdirected to me. For instance, research has shown that the appearance of Melanocortin receptors throughout the body and in the skin and brain particularly demonstrates that they play a VERY important role in the defense of the body and are a vital part of the immune system. To not comment on this fact or to brush it off as what was the phrase, "just not practicle or possible" or not "ethical" at this time seems misguided. Cosmetically, yes, but as for the other possibilities, WTF? PW, please correct me if I am wrong.

While I will be holding on to my CUV stock, at the same time, I will be looking for other companies who wish to exploit the tremendous potential health benefits of this drug. My original question (asked last September) about the patent rights of Clinuvel regarding Scenesse where it concerns its anti-inflammatory, anti-microbial, and anti-oxidant effects have never been answered. And in fact, the Chairman's Address presented some doubt in my mind if the company will even pursue this direction in any meaningful way and in any meaningful timeframe, as I have heard no statements to contradict my fears other than ... maybe down the road we might look into it?

If some people on this forum want happy talk they are entitled to their opinion. If others want a counter-balance to happy talk presented with logical reasoning by somebody who has been tracking the progress of this drug for 14 years ... you will hear it from me. As a long term investor, I appreciate the work that has been done thus far. It truly is a tremendous accomplishment. My point however is, when research has proven that we stand at the precipice of science with this drug and the company shrugs off its potential with two sentences in the Chairman's Address, some of us investors better take notice and start asking hard questions ... and keep asking them until we get answers from management.

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endymion96
Posted on: Feb 7 2015, 10:19 AM


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I feel like Linus ... waiting for the Great Pumpkin to appear out of the sky! Sad to say, but I have heard what you are saying many times before. At this point, actions speak louder than words. So I will sit and wait in the pumpkin patch until that day comes.
The reason I believe PW is not on target is because of a post I made about a month ago which showed hard scientific fact that anti-biotics paired with a long-acting MC1R analog will do amazing things. If I were PW, I would start game planning this new capability as fast as I could. If he wants to light a fire under the share price and assist all of the longs as he said he would, that syngistic effect is the golden ticket and the way up on a rocketship. Another reason to want to boost SP is no fear of a takeover or a buy-out. Simply the mere mention that Scenesse along with an anti-biotic can cure the most virulent strain of MRSA out there (given the safety profile established already) would be a home run ... even at Phase II.
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endymion96
Posted on: Jan 12 2015, 05:28 PM


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Yep, this is what I have been saying all along.
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endymion96
Posted on: Jan 7 2015, 09:46 AM


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We already know the answers. Its not one incident of sunburn that can cause skin cancer, nor is it a long buildup of UV exposure over one's lifetime that causes it either. Skin cancer will occur when certain parts of your DNA have been mutated such that some genetic piece no longer function(s) and/or causes certain cellular imbalances. Repeated UV exposure for sure increases the chances that certain harmful mutations may occur, but skin cancer is not gauranteed by some arbitrary long period of time ... it completely depends on which mutations occur (because the body failed in preventing or blocking them although it usually does) ... and its not just one mutation, its several specific ones. You'd have to be unlucky enough to be afflicted with just these mutations.

So the development of skin cancer is a series of specific mutations. Its like unlocking the combination to a multi-combo lock. How many digits in the combination, I am not completely sure, but there are several. Wth each UV exposure you take the chance that one of the digits in the combination is found. Eventually, if you are unlucky, your repeated UV exposure will finally crack the lock and open the cancer vault. Scenesse skips the inherent riskiness of exposure and in fact strengthens the lock by boosting the immune system repair pathways which insure the lock's combination stays secure. In other words, it prevents the digits of the combination from being found. The tan is a side-effect.
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endymion96
Posted on: Jan 4 2015, 04:36 AM


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You don't seem to be listening. Do you think my "overdose" was the normal? No. I was experimenting just as Epitan was experimenting with dose ... but on my own. And from my experiences with dosing levels ... and from Clinuvel's reported info on their slow-release implant, I am telling all who read this, it is NOT slow enough. From the info Clinuvel reported of VERY COMMON and COMMON side-effects ... and from my own experiences in very much lessening those stated side-effects, I am telling all who read this, it can be done. Why after all that did I invest? Because the drug works. Period. What do I think of PW and his golden compensation package, I was iffy before, but after discovering the posted side-effects, not much at all. Wondering who is really minding the store now? I invested because the drug works and this is the company with the rights and patents. Simple as that. It works so well, if you have dry skin in winter ... so dry that you scratch yourself raw, then take 1mg every other day 4 times for a total of 4mg ... no more dry, itchy skin for two months ... Enough to get you through winter's harshest. And the first subcutaneous injection made the itch go away, the rest were for a lasting effect. I suspect those suffering with EPP are willing to take on the side-effects because they are temporary unlike the disease they are afflicted with. I would as well. The thing is, once the drug is in your system and active, re-taking it a couple months later, the side-effects aren't as great. But to those who had never been exposed, the first time will be a doosey unless Clinuvel heeds my advice and make the so-called slow-release implant alot slower. All that said, it is a life changing drug. Do see now why it was not such a slam dunk weall thought it was with the regulators? But the thing is, it could have been. And with a small change it could be rectified.

P.S. in my opinion, a cure for dry skin is the very, very, very, very least of good things this drug will treat. I have unlimited optimism for this drug. My negative comments as to its administrative protocol not withstanding.
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endymion96
Posted on: Jan 1 2015, 06:25 AM


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Excuse me but were you one of the early pioneers running experiments with the real drug? Have you experienced what it feels like to overdose yourself on this? You feel absolutely sick to your stomach and will vomit within 30 minutes. You will not be able to sleep. You will have a headache for many hours. You will feel the need to continuously stretch your body. You may have facial flushing and feel hot. You will not want to eat for feeling nauseous. Your sinuses will act up and it will appear as if you have a cold. Don't brush off my complaints like that. You know nothing about it. I have experienced it first hand. If its bad enough, you will feel like you are going into shock and need to lay down ... but you can take an antihistamine to countact the effects. Once you have experienced an overdose, you never want to do that again. Its freaking ridiculous that these effects are counted as very common and common among the patients. All that is required is to lower the level of steady stream dosing to minimize them and yet Clinuvel at this point is going to market with the current implant. Yeah, its tolerable, but why should anyone tolerate it when it can be corrected? After all this time. Sorry to be the bearer of unpleasant news, but this is a misstep regardless of whether you want to believe it or not.
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endymion96
Posted on: Dec 31 2014, 02:12 PM


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In addition, you have to condition the body to deal with Afamelanotide with very small dosing levels at first then build up to a bigger level. The slow-release has to be tapered if that is even possible. Facial flushing and vomiting? Oh my goodness, I did not expect this kind of misstep at this point. I certainly hope somebody from Clinuvel is reading this and the lightbulb turns on.
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endymion96
Posted on: Dec 31 2014, 01:59 PM


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I can't believe after all their trials ... that they do not know the reason why there are so many common side-effects ... it is because they are releasing too large of a dose in too short of a time! It is incredible to me. If they could develop a better slow-release formula, these side-effects would be minimized completely and may not even be felt other than the back needing a good stretch and a lessening of appetitie. Headaches and nausea would go away. Do they not know this at this point? What the hell? You can't release 90% of 16mg in 48 hours. That is ridiculous. I'm very shocked. No wonder the drug was approved under extraordinary circumstances. Please Clinuvel, do yourself and your patients a favor and refactor your implant.
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endymion96
Posted on: Dec 11 2014, 09:33 AM


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Sorry, wrong choice of words. Completely cosmetic is not what I meant, perhaps cosmetic in appearance is better. But of course, the negative psychological effect is not something to simply brush aside and it is the entire reason that Clinuvel chose this path. In my opinion, this disease was chosen in the short term because it is bonified, but it also shows the power of the drug's pigmentary response. However, my point is that people die from other diseases where research has shown that a-MSH analogs will improve, treat, and maybe even prevent such as Alzheimer's Disease and the damaging effects from a stroke.
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endymion96
Posted on: Dec 11 2014, 08:38 AM


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I also found that phrase a curious turn of words. Thinking on it further, it makes no sense at all. A Vitiligo treatment would be completely cosmetic and I have no doubt that Scenesse works not only as a photo-protective drug but also as an anti-inflammatory with EPP. So what is he really saying? My guess is it has something to do with the regulatory bodies and the pressure they are exerting on the company not to let the cat out of the bag just yet. Although I could not blame management for going along, I do wonder when the dam will burst? I think we all need to hang in there for at least two more years to see if the regulatory bodies relent. The science is becoming hard to ignore. Along those lines though, how could they prevent a synergistic use with antibiotics? If PW is not aware of this research, somebody needs to let me know. Because if the real reason of slow pace is regulatory in nature, this type of new research could make acceptance more palatable.
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endymion96
Posted on: Dec 10 2014, 04:44 PM


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New research shows that a-MSH combined with conventional antibiotics makes for a potent weapon against bacterial infections such as MRSA. I'm sure you've all heard that humanity may be reaching the end of the line with antibiotics against the mounting resistance of bacteria. Well, this articles explains that this point of view may no longer be true. This is a very exciting prospect for Clinuvel. It is my belief that taking the company in this direction would lead to more profitable results. Or at least the announcement along such lines. This is the kind of thing that excites investors. Hello PW, are you reading this? Make it happen before somebody else does.

http://www.plosone.org/article/info%3Adoi%...al.pone.0073815
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endymion96
Posted on: Dec 3 2014, 03:27 PM


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I can add a little to this discussion ... a long-lasting form of alpha-MSH such as the drug we have all invested in has many potential benefits. Tumor growth is driven by the cell's ability to outwit the normal processes which cause it to die. Normally, a cell has a limited lifespan and can only divide so many times before its ability to divide further is degraded to the point where it enters into the death phase and is purged from the body. Cancer is the ultimate form of mutation, but it takes many DNA mutations to get to this point. Along the way, these mutations may bring about a form whereby the processes that control cell death are shut off and cancerous or pre-cancerous cells become immortal (able to divide indefinitely). But in order to get to this state, the DNA mutations must occur. So the question is, how do these mutations occur? There are several ways but UV damage, heredity, carcinogens, and free radicals all play a part. The great news is that our little wonder drug turns on many valuable pathways that defeat such situations from getting out of hand and may even play a part in stalling or reversing the aging process. It does this through its anti-inflammatory effects, and DNA repair pathway effects, its anti-oxidant effects, and its increased production of eumelanin which provides UV protection. This is why I am willing to wait it out. Because of its long-lasting effects on the MC1-R, Scenesse provides much more than simple photo-protection. I am still researching when I can, but I am looking to see if its effects on the body actually work in a way to halt tumor growth. I have reason to suspect that it can because if it does, it would solve the progression of many types of cancers due to the fact that once a cell can no longer divide indefinitely, it will eventually die out and thus, if it is cancerous, the cancer would in turn eventually die as well.
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endymion96
Posted on: Dec 1 2014, 05:31 AM


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I am going to hang on for another year or so and see what FDA approval brings? My hope is that Scenesse gets approved in the USA and that regulatory restrictions aren't as tight as they are in Europe. Then I am going to hope for off label prescriptions for other indications and word of mouth to spread in a big pool of potential investors.
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endymion96
Posted on: Nov 29 2014, 04:58 PM


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I don't think there is anybody out there that does not appreciate what has been done here to date. But let me say this, Instead of investing 10 years ago, I could have bought all my shares in July and done just as well. All I want to know from the management team is the forecasts for future milestones so that I can gauge my profitability timeline. If that happens to be 5 years from now, I will take my money out and come back later. It is not a bad thing to want to know these things. Time is money.
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endymion96
Posted on: Nov 25 2014, 03:10 PM


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I am also reading that an alpha-MSH derivative with a long half-life (Nle, D-Phe alpha-MSH or NDP-MSH) had the beneficial effects of reducing neuronal death (death of brain cells) and hippocampal damage and thus, improved functional recovery from stroke if given treatment between 3 and 9 hours after insult of stroke. In the US, the stroke is the 4th leading cause of death affecting something like 800,000 people a year. Imagine the possibilities?
Here is the article. It is a recent 2013 general survey of alpha-MSH and its anti-inflammatory effects. Clinuvel and other companies are mentioned toward the end.

http://www.hindawi.com/journals/iji/2013/985815/
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endymion96
Posted on: Nov 25 2014, 01:38 PM


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Treatment for arthritis anyone?
"Our results indicate a-MSH and related peptides as a potential new class of drugs for the treatment of inflammatory arthritis."

http://arthritis-research.com/content/11/5/R151


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endymion96
Posted on: Nov 25 2014, 01:19 PM


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I thought you had the right intuition, but wrong timing. I would have waited until after AGM. I am expcting a surpize to come out of that meeting. But you got back in, I think in the nick of time.
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endymion96
Posted on: Nov 18 2014, 01:16 PM


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Exactly, which is why I would like to hear a response straight from the horses mouth. We, as shareholders, need to judge just how great of an investment owning a share in this company is. We need to know when to expect a good return on our investment. If the answer to my questions is that they don't have it all locked up, then my next line of questioning will center on how soon will we see shareholder value increased and what are they going to do to make that happen. And finally, this can all be traced back to Resolution #9, Dr. Wolgen's proposed compensation and hitting the proposed goals set forth. I, like a few others, think those goals are not set properly and I also think the compensation is too much (at this time). We all need to be treated fairly. And compensation should be rewarded when fairly earned. Getting a drug approved by EMA is a major milestone indeed, but so is 10 years of investment without a return. Both balance each other in terms of patience and committment.

From what I read in the Annual Report, Dr. Wolgen and company have laid out solid plans for the future and I applaud them for this direction. What I need to know is, will my investment be a good one or a great one. Time is money. I can almost guarantee that if, Dr. Wolgen wants that compensation package, then he will pull out a surprize for us before the AGM occurs. Shareholder voting ends Wed, Nov. 26 I believe. So we may have news before then.
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endymion96
Posted on: Nov 17 2014, 08:55 AM


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Does anybody know the answer to the following questions and if not, can somebody ask it at the AGM? The question is, "Does Clinuvel hold patent protection over future possible indications of Scenesse such as those associated with its effects as an anti-oxident and/or as an anti-inflammatory?" In addition, "How will Clinuvel position itself to 'stay steps ahead' of the competition (as Dr. Wolgen stated in the 2014 Annual Report) and in what regard? Branding/Marketing, IP, Research, etc?".
Along those lines ..."Is patent protection limited to drug delivery methods targeting MC1-R at this point? Or is it strictly limited to only the exact formulation of Scenesse targeting at MC1-R? Or does it encompass all analogs of alpha-MSH? Please elaborate. Could a competitor develop a different analogue and target MC1-R? Just how is Clinuvel insulated from competitors at this moment and how long will it enjoy such beneficial positioning?"

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endymion96
Posted on: Nov 6 2014, 11:07 AM


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I think the big prize will be had once they finally prove that this drug can be used as a preventative for skin cancer. That is a clear medical need and appropriate use. It is also what the discoverers of the drug had envisioned when they first set out to do the research. The buzz over a preventative/treatment/cure for skin cancer is what the investment world will go bonkers over! Imagine that?
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endymion96
Posted on: Nov 5 2014, 02:49 PM


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Who would vote for this takeover bid? I wouldn't.
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endymion96
Posted on: Nov 4 2014, 02:40 PM


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But I have been saying all along that strategy won't work with this group because we keep buying on the troughs and not selling on the crests ... most of us anyway.
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endymion96
Posted on: Nov 4 2014, 02:36 PM


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If the manipulators are manipulating, they are doing it for a reason. Could there be a large shark looking to shake out the small players with crazy SP moves? I could see somebody doing the old rope a dope. Swing up then down, then up and down ... and lull all of to thinking it will be safe to sell at the high side and buy at the low side. And as we take ever bigger risks by putting more of our shares out on the crests and troughs, they will at some point in the future ride a big wave up and this time buy out the sellers and push the SP way up. Then some of you will be caught with your pants down? I don't know ... Just trying to put out a plausible scenario on the manipulation. Otherwise, why start swinging it up and down? Why not push it up and keep it there?
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endymion96
Posted on: Nov 4 2014, 09:29 AM


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Yes, I saw that too .. as Seeva pointed out. Either the ADR market did not buy what the AUS market was selling yesterday and is now establishing a more normal SP rise or the ADR market is very, very thin and should just be ignored? Or a combination of both if that makes sense? It will be exciting to see what the AUS market does today. My belief (as I stated yesterday) is that the manipulators are testing the sell point. If we don't see a big sell side today, they may just push the SP even higher until they see action. At that point, they will know the current high/low sides. If my theory is correct, must of us are long and they will need to push the SP higher than they think.

If any of you on here are selling, it would be interesting to know if you are just taking some profits because you don't think the SP can get higher for awhile or if you are reducing your holdings for good because you want out? Personally, I never used to play the roller-coaster games because I always thought that this stock would take off like a rocket and not come back down to these levels ever again. Over the years, I've seen things play out differently. That is why I think its going to be really hard to push the SP up until we get above of the $10 range.

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endymion96
Posted on: Nov 3 2014, 04:51 PM


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Oxidative stress comes about due to the production of pheomelanin. I find it interesting that the sufferers of Vitligo are often in the higher Fitzpatrick groups ... their melanocytes normally produce eumelanin except in areas where they don't ... hence the patches of lost pigmentation. We know that Scenesse seems to bring back the pigmentation and fill in these areas. So it is acting as a powerful anti-oxident and also is switching back on the repair pathways.
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endymion96
Posted on: Nov 3 2014, 03:51 PM


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If anybody wants to get an idea of just which pathways, targets, processes, genes, enzymes, and in general, biology is involved ... have a read of this article by Dr. Fisher and Dr. Hsiao. It is very new, August 2014. I was reading it trying to find more info on how an alpha-MSH analog could effectively prevent or reverse melanoma. The key here is MITF regulation. It is the master regulator of the melanocyte cell.

http://www.sciencedirect.com/science/artic...002707?via=ihub
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endymion96
Posted on: Nov 3 2014, 02:33 PM


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Anybody think this is a test to see when the longs might start selling a bit of their holdings? Or am I being a conspiracy theorist?
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endymion96
Posted on: Nov 3 2014, 10:00 AM


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Posts: 409

Klomp, thank you for posting the info. I don't think Scheme #1 will occur unless the bid would be substantially higher, say in the $20-30 range (and even then the BOD would only give you the chance to vote, I couldn't say what the outcome would be). By virtue of an approved drug, with more indications and other formulations to undoubtedly come down the pike, the company now has a sure revenue stream coming in. The BOD, I think, would reject any such low-ball offers below $18 because of that. Especially since they have once again reiterated (for the third time) that Clinuvel is transforming into a major commercial operation. Wolgen of course wants to be at the helm of an historic company such as this with a drug that will change the world.

Scheme #2 may be a slight possibility only in the sense that some entity may gain a majority of the shares, but I doubt it would come close to a takeover because most of us longs (and quite frankly that probably includes 80% of the shareholders as my guess) aren't going to reduce our holdings by any substantial amount. We all realize the potential ... and have realized the potential from the very beginning. I think this is in fact how we all found out about this company ... we researched the topic, found the drug, which led us to Epitan/Clinuvel, and then we invested heavily. It is my belief that the makeup of the shareholder base with its long standing position in holding shares will not let go until we receive just reward for our long wait. When that day comes, all who are invested now will have ample opportunity to sell their shares to a large pool of brand new investors who will be buying in at 10-20x today's price. That is my take anyway.
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endymion96
Posted on: Oct 31 2014, 06:10 PM


Group: Member
Posts: 409

One last thing. I wanted to point this out a few days ago when it crossed my mind, but forgot about it. After reading the Florian post, the idea surfaced back into memory. Wolgen and others in Clinuvel stated that "safety" is THE number one priority going forward. To me, this is a signal that he is setting up the prospects for all future indications to adhere to that one principal for one gigantic reason. Years from now, when the safety profile is set in stone ... this drug will eventually go mainstream. Perhaps for mostly humanistic reasons, deservedly so. And why shouldn't it? And why shouldn't we reap the rewards? People keep talking about a potential buyout by Big Pharma? Nonsense. Wolgen alrady telegraphed he is not going to let that happen. And as I said previously, the regulators are not yet prepared to let the dogs loose on this drug so it will not even be a possibility for years. By that time, things will be well in hand.
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endymion96
Posted on: Oct 31 2014, 05:29 PM


Group: Member
Posts: 409

Since Florian seems to read our posts, let me say, I agree whole-heartedly on the human dimension. I venture to say almost everyone on here invested in this company because of it. And of course because we saw the huge potential for this drug to treat millions of people, we as investors also saw the huge potential to gain monetarily from the science. My personal story ... I am one of those guys who does not tan. Never have. I remember getting savage burns at the beach, while my friends soaked in the sun. This sad fact led me to do research on the internet to try and discover how I could protect myself and maybe even improve my appearance. Of course I saw all the fake products and even tried them, but there was this one bit of research that actually held promise of a cure for my condition. I eventually became so obsessed, I started reading 1000 page books on "The Cell". I become interested in biochemistry and Immunology and I even thought about going back to school to earn a degree in the field.

But, as the summers went by and progress was slow, I took to researching the patents to see if I could get my hands on this drug. Because of my condition, I was willing to take the risk. But I did so with reputable peptide manufacturing companies here in the US. That first summer 8 years ago ... as I sat on the beach in mid-day sun, after having experimented with dosages and gone through an experimental course, I sat there in disbelief. No burn ... maybe a little color after a full afternoon, but knowing what I'd experienced all my life, by comparison, there was no burn. At that point, this drug was my miracle cure. Invest in Epitan, oh yeah you better believe it!
So, my point is, most of us here probably bought this stock years ago, when the risk was very high, and the probability was that it would never succeed, on faith that a cure might eventually be available. Most of us bought this stock because we were sufferers of various skin disorders, but we had hope that one day there would be a miracle cure. So now, after 10 years of waiting ... I want my cake soon and I will someday eat it too. Anybody else with me?
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endymion96
Posted on: Oct 31 2014, 03:31 PM


Group: Member
Posts: 409

I think we all kinda know when this rocket is going to leave the launch pad. It will happen when we start seeing much more revenue come in. Money talks, bullsheet walks. Next on the agenda will be FDA approval, US market investors will then think, hmmm this company has just opened up the market to a bunch more people. Then of course, the Vitiligo trials will attract attention. At this very moment, the thing that will push momentum forward is insider buzz. I still have yet to see the folks who provide the stock tips to the masses tip them off to our de-risked beauty. That should happenly shortly. That is currently what I am tracking ...
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endymion96
Posted on: Oct 31 2014, 03:14 PM


Group: Member
Posts: 409

In The Groove! Now there's a blast from the past. What about Melanotan? I wonder if he's still around too?
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endymion96
Posted on: Oct 30 2014, 09:30 AM


Group: Member
Posts: 409

Don't forget Eczema, Rosacea, AK ... Wolgen hinted at SAD too ... not to mention there have been no trials to see whether this would reverse or prevent Melanoma or SCC. Clinuvel should at least run the mice studies and see what those results are. Imagine if they were positive ... that is the kind of buzz that would shoot the SP up to where it should be. For that, I would let Wolgen have his performance bonus.
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endymion96
Posted on: Oct 29 2014, 04:03 PM


Group: Member
Posts: 409

I am just tired I guess. I have been holding my shares for almost 10 years. Shouldn't that be worth something by now? Figuring the time-value of money? I guess I will go back to hibernation. On the bright side, my investments in other areas such as graphene, 3D printing, uranium, and SSD technology are doing well.
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endymion96
Posted on: Oct 29 2014, 03:13 PM


Group: Member
Posts: 409

This is not shareholders at all. Did you see PortoMan's chart? Who sells 17, 1, 22, 7, etc ... shares every 5 minutes? It is a conspiracy. They way you frame it, it makes one think people are done with the stock. That simply is not the case. But that is exactly what the manipulators want people people to think. So why reiterate their bull?
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endymion96
Posted on: Oct 29 2014, 11:26 AM


Group: Member
Posts: 409

The volume is low and yet these manipulators who are selling and driving the price down further ... they are killing the goose for the long run. Imagine you are a new investor looking at this company's stock price fluctuations! Who would come in and join a party like this? Anybody out there with a lot more money than me, you might wanna consider playing the game in the opposite direction to counteract this nonsense. Why don't you try buying anywhere from 1-70 units every five minutes and push the price up? Freaking ridiculous that the price would drop so low just after the company has de-risked. Sure you make a few bucks for now ... but if you let the SP build, you might attract more people to the company and sell later at a much higher price! Well my friends, after the manipulators have had their fun, where will we be? I don't see this mess straightening out until the company starts raking in serious revenues.
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endymion96
Posted on: Oct 29 2014, 03:00 AM


Group: Member
Posts: 409

It is probably a group of people in collusion ... would be akin to a group of card-counters ripping off the casino. Porto's got it right though ... fantastically small parcels being bought at 5 minute intervals. This group aren't very refined.
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endymion96
Posted on: Oct 29 2014, 01:27 AM


Group: Member
Posts: 409

Manipulation is easy and could easily go the other way, but for now, the downers are controlling the game. Any uppers in the house? How low will they drop this stock? Last time it was down to $2. Just remember people ... until we get a wider shareholder base, this kind of thing will continue. Do not despair! I wonder if I should go back into hibernation so as to forget about these quick traders for awhile? They are really annoying.


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endymion96
Posted on: Oct 28 2014, 02:41 PM


Group: Member
Posts: 409

I can't tell you how excited I was to read the report. There are so many hints in that thing as to where Wolgen thinks he can lead us, its just incredible. The future of this company is going to be huge. If anybody hasn't read it yet, read it a few times and you'll see Wolgen is pretty clear in his wording that he can take this company to the top without a doubt. When I read about Seasonal Affective Disorder in the report ... that pinged my radar screen. Call me crazy but that may become a future possibility for this drug. Probably way in the future, but he is definitely hinting at a wide market potential. If the FDA and EMA need diseases, we'll give them diseases to treat. I think that is what he is hinting at. But again, this must be done slow and steady ... so we have a ways to go.
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endymion96
Posted on: Oct 28 2014, 02:31 PM


Group: Member
Posts: 409

Normally, your analysis would be spot on, but I know many investors have been in this stock for so long they have grown grey hairs by now and just want to take what will be a nice profit and get out while they can still enjoy it. That is why I see a tough slog up around the $10-15 dollar range. When we burst through that, the sky is the limit ... but as said, not for several years. If I am wrong, I will be very happy to be wrong. But seriously now, how could anybody be selling this stock when the company and the management team and the future possibility for treating a wide range of skin diseases is so clearly attainable? This is why I say the only sellers now are the day traders who have no knowledge of this company, stock, or drug. It makes me ill, but in the end, we'll all meet on the beach and have the last laugh. Those day traders are just making it that much longer to get there. But really, what roadblocks does anybody see at this point?
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endymion96
Posted on: Oct 28 2014, 10:41 AM


Group: Member
Posts: 409

My honest opinion on this stock right now is that the people who are buying is basically us ... who've known about and been invested in this company from the beginning and perhaps those who came in several years ago. Those selling are professionals who were tipped off about this stock and are in it for a quick buck. Until volume gets into the millions, the SP is up for manipulation down/up. The problem with this short-sighted thinking is that eventually those of us buying will run out of money and/or be beaten into submission such that we will no longer be buyers. And then what happens? Those dummies who are selling have lost out on selling at a much higher price because they thought they could milk this cow all day long. What they don't know is how many trials and tribulations we longs have suffered over the years. So if they want to play this game, they are basically killing the goose that lays the golden eggs for quite some time. Price spikes that we dream of seeing are still far off because of this. If you are waiting for $10-$15 range, that will not happen until after FDA approval and Vitiligo trials are over and Vitiligo indication is approved. At that point, we will sit near $10 because some longs will just want to get out and take a modest return on all their years of investment. If you want to wait for the big bucks, that is still 5 years off in my opinion. Medium bucks is 1.5-2 years away.
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endymion96
Posted on: Oct 28 2014, 08:44 AM


Group: Member
Posts: 409

And volume was 10x normal ... so that is pretty good, eh?
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endymion96
Posted on: Oct 28 2014, 02:42 AM


Group: Member
Posts: 409

"Can we seriously expect Clinuvel to manage an indication like Vitiligo without partnership? Assuming approval is 2-3yrs away, we would have to build a substantial global network at large cost. Would the regulators be similarly "scared off" by a partnership with Big Pharma?"

I'm not sure, but this is what I believe Clinuvel stated in their latest announcement ... and that is why I brought it to everyone's attention. What is your take?
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endymion96
Posted on: Oct 27 2014, 03:57 PM


Group: Member
Posts: 409

If what I read and surmised is correct, Clinuvel cannot consider a buyout from a large pharma because they would then scare off the regulators. They would scare them off because EMA does not trust that proper care would be taken to limit off-label use in the much larger distribution channels of these giant pharmas. So, Clinuvel is now stating that they are transforming from an R&D company into a commercial operation. This is necessary to prove to the regulators that if/when future indications and drugs come before their panels, upon approval, that the company can be trusted due to its intimate relationships within the field of prescribing medical professionals. At the same time, Clinuvel will be expanding the market with such indications and drugs under protection of IP and market exclusivity as a growing pharma in its own right. The future looks very bright!
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endymion96
Posted on: Oct 25 2014, 12:57 PM


Group: Member
Posts: 409

One thing bothers me about the EMA press release and that is that they stated that .... there was a lack of robust efficacy data because of the difficulties of placebo-controlled trails. Patients in these studies were not willing to expose themselves to sunlight for fear of developing painful symptoms. They went on to say that approval was given under exceptional circumstances with the condition that Clinuvel puts in place a robust risk management plan that ensures close surveillance of the safety and efficacy of the medicene. As part of this plan, the company will establish a registry of patients to collect safety and efficacy data.

My take on this is that EMA really wants a tight leash on Scenesse right now because they are afraid of the off-label use. I simply cannot believe there is a lack of robust efficacy data with this drug. That is a crock. If that were true, they should have denied it. But they didn't. This tells me the data was a slam dunk; however, in order to grant approval, they needed a plausible reason to put a condition on the drug that they felt would provide a reasonable hurdle (for now) to prevent runaway use. And that is this condition to establish the registry for "surveilance" and the additional paperwork that prescribers must adhere to in order to follow up on all patients given the drug. That said, I'll take the unanimous decision and couched language as a sign that what we have here is a blockbuster drug.

I'm sure they would have liked to see more data on this drug's effects with other skin disorders though ... as they know it has positive effects as an anti-oxident and anti-inflammatory and its activation of DNA repair pathways has huge potential for an advancement in medicene. But seeing as how these trails are years off, they decided to go ahead with approval ... as well they should have.
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endymion96
Posted on: Oct 25 2014, 04:39 AM


Group: Member
Posts: 409

That is correct. The larger, more liquid market on the ASX will reset the tone on Monday. I expect that the ADR "market close" price on CLVLY will NOT set the real price and that CUV will push higher on the ASX (factoring in the exchange rate) in relative terms because of the bigger pool.
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endymion96
Posted on: Oct 25 2014, 03:21 AM


Group: Member
Posts: 409

Hi all, not to throw water on the parade but my prediction (a few days ago) that this stock will now trade in the $4-5 range is probably accurate. Although the ADR volume is huge today, I still think this a thinly-traded stock that is open to manipulation. I haven't sold any shares in 10 years and I'm not about to with EMA approval accomplished. Now its on to FDA approval ... which will be another huge upswing. But with what I have seen, don't expect to cash in just yet. In the coming months there will be downward pressure from those with big piles of shares wanting to cash in some portion of their treasure trove ... especially when the SP hits the $10-15 dollar range which will not occur for awhile (my estimate). So, those waiting to see the $40-50 range like me have a ways to go. But I'll wait ...




On the plus side of the ledger, we have EMA approval and the potential for this drug to prevent/treat/cure many other diseases ... also now that Clinuvel has made its first big splash in the biotech world, there will be the analysts reports which will attract the attention of the big boys. So that is good for moving the ball up. As with the energy sector, this game is not easy but I hope we all make it to the finish.


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