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Tomsk Company "SAVA" Has Signed an Agreement to Supply Products to China for $100 Million.

An agreement of intent to purchase Tomsk products was signed on November 6 at the Russian Export Center stand as part of the First China International Import Exhibition (CIIE), which runs from November 5 to 10 in Shanghai.

Corresponding agreements between the Russian OOO TPK "SAVA" and the Chinese Xinjiang Er Liang Organic Products Group were reached too. The agreement provides for the readiness of the parties to arrange deliveries to China of Russian products from 2019. This includes jam, juice, functional nutrition and semi-finished products for industrial enterprises.


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  • 1 month later...

Well not too much occurring other than we know some sales are happening again.

Taiga A320 back on the shelves in Oz after a long stock shortage.

There seems to be more outlets now particularly offering the Core NRG energy booster drink.


However some other interesting things are happening too.

Attached is a medical journal article just released on a Ropren mice trial for potential treatment of MS funded by Russian Ministry of Education & Science with the study conducted by academics from Tomsk State University along with University of Washington USA (yes a USA link!). To be fair there is a Prenolica representative on the scientific panel as well.

It is a very interesting read with some seemingly outstanding results achieved in the mice study.


I'd like to hear some others thoughts on the study outcomes as I'm no medical guru.





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I think NRG combine SLA bioeffectives with their own ingredients. Anyway, I reckon they are small outfit but I could be wrong! The main game is with Vilavi. In some of the chat forum, they are claiming increases of >1000 customers/d as of circa 2018. Interestingly, claims of >1b rubles as of DEc 2018 . Have lost that link. Whatever happen to Dr. Oz???
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  • 2 months later...

More seminars, now at the end of June in Manchester, UK for Formula X Nanoformulation Conference.





Infectious Disease Research Institute from Seattle, Washington and Colorado State University in collaboration to present.

Prenolica appears to have supporting role with Vagif being included.



Formula X C-02 Manchester

Vaccine Adjuvant Activity of Conifer-derived Oil-in-Water Nanoemulsions

Christopher B. Fox1, Neal Van Hoeven1, Brian Granger1, Susan Lin1, Jeffrey A. Guderian1, Airn Hartwig2, Nicole

Marlenee2, Richard A. Bowen2, Vagif Soultanov3, Darrick Carter1

1 IDRI, Seattle, WA, USA

2 Colorado State University, Fort Collins, CO, USA

3 Prenolica Limited, South Melbourne, Victoria, Australia

Contact Email: cfox@idri.org

Abstract: Next to aluminum salts, squalene nanoemulsions comprise the most widely employed class of

adjuvants in approved vaccines. Despite their importance, the mechanisms of action of squalene nanoemulsions

are not completely understood, nor are the structure/function requirements of the oil composition. In this study,

we build on previous work that compared the adjuvant properties of nanoemulsions made with different classes

of oil structures to squalene nanoemulsion. Here, we introduce conifer-derived polyprenol nanoemulsions as

novel vaccine adjuvant compositions. In contrast with long-chain triglycerides that do not efficiently enhance an

immune response, both polyprenols and squalene are comprised of multimeric isoprene units, which may

represent an important structural property of oils in nanoemulsions with adjuvant properties. Oils were extracted

from conifers and used to prepare oil-in-water nanoemulsions by microfluidization. Conifer-derived

nanoemulsions were formulated with or without a synthetic TLR4 ligand and characterized regarding

physicochemical and biological activity properties in comparison to squalene nanoemulsions. Emulsion droplet

diameter stability was characterized by dynamic light scattering. Nanoemulsions were evaluated for in vitro

biological activity using human whole blood, and in vivo biological activity in mouse, pig, and ferret models when

combined with pandemic influenza vaccine antigens. Nanoemulsions comprised of conifer-derived polyprenol oils

demonstrated long-term physical stability, stimulated cytokine production from human cells in vitro, and promoted

antigen-specific immune responses in various animal models, particularly when formulated with the TLR4 ligand

GLA. Conifer-derived nanoemulsions are compatible with inclusion of a synthetic TLR4 ligand and promote

antigen-specific immune responses to pandemic influenza antigens in mouse, pig, and ferret models.[/font]

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