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Alterity Therapeutics Limited (ATH), formerly Prana Biotechnology Limited, is an Australian biotechnology company which focusses to commercialise research into Parkinsonian movement disorders, Alzheimer's disease, Huntington disease and other neurodegenerative disorders.

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ATH has today announced the award of a grant from The Michael J. Fox Foundation for Parkinson’s Research to determine optimal dosing of its lead drug candidate ATH434 for Parkinson’s disease (PD) based on imaging of brain iron.


The funding for US$495,000 will be used to evaluate the pharmacologic profile of ATH434 in a primate model to determine the optimal dose of ATH434 in future Parkinson’s disease clinical trials. This is the second grant that Alterity has received from The Michael J. Fox Foundation to support the development of ATH434 in PD.


Alterity Chief Executive Officer Dr David Stamler said,

The Michael J. Fox Foundation is an incredible organisation at the frontier of research and treatment innovation for Parkinson’s disease, which remains incurable and affects an estimated 7 to 10 million people worldwide.


ATH434 targets alpha synuclein misfolding and aggregation through the redistribution of excess labile iron, and our first indication Multiple System Atrophy (MSA) is on track to start its phase 2 clinical trial later this year. The potential to expand into other Parkinsonian disorders that implicate alpha synuclein has always been part of our strategy and this funding allows us to take another step towards realizing a program in Parkinson’s disease.

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